公开(公告)号：EP0832271B8

公开(公告)日：2005-03-02

申请号：EP96922432.8

申请日：1996-06-06

申请人： INEX Pharmaceuticals Corp.

发明人： WHEELER, Jeffery, J. ,  BALLY, Marcel, B. ,  ZHANG, Yuan-Peng ,  REIMER, Dorothy, L. ,  HOPE, Michael ,  CULLIS, Pieter, R. ,  SCHERRER, Peter

IPC分类号： C12N15/87 ,  C12N15/88 ,  A61K48/00 ,  A61K9/127

CPC分类号： C12N15/88 ,  A61K9/1272 ,  A61K47/6911

摘要： Novel lipid-nucleic acid particulate complexes which are useful for in vitro or in vivo gene transfer are described. The particles can be formed using either detergent dialysis methods or methods which utilize organic solvents. Upon removal of a solubilizing component (i.e, detergent or an organic solvent) the lipid-nucleic acid complexes form particles wherein the nucleic acid is serum-stable and is protected from degradation. The particles thus formed have access to extravascular sites and target cell populations and are suitable for the therapeutic delivery of nucleic acids.

公开(公告)号：EP1503793A2

公开(公告)日：2005-02-09

申请号：EP03722134.8

申请日：2003-05-12

申请人： Inex Pharmaceuticals Corp.

发明人： TAM, Ying, K. ,  SEMPLE, Sean ,  KLIMUK, Sandra ,  CHIKH, Ghania

IPC分类号： A61K39/39 ,  A61P37/04

CPC分类号： C12N15/117 ,  A61K39/0011 ,  A61K39/39 ,  A61K2039/541 ,  A61K2039/55555 ,  A61K2039/55561 ,  C12N2310/315 ,  C12N2310/3341

摘要： The invention discloses cancer vaccines comprising lipid-nucleic acid formulations in combination with one or more tumor-associated antigens which are capable of stimulating strong, Th-1 biased cellular immune responses to said tumor-associated antigens in vivo. It is further disclosed the subject cancer vaccines provide therapeutic efficacy in treating tumors in an animal.

公开(公告)号：EP1328254A2

公开(公告)日：2003-07-23

申请号：EP01983342.5

申请日：2001-10-25

申请人： The University of British Columbia ,  Inex Pharmaceuticals Corp.

发明人： CULLIS, Pieter, R. ,  MACLACHLAN, Ian ,  FENSKE, David, B.

IPC分类号： A61K9/127

CPC分类号： A61K9/1272

摘要： The present invention provides lipid-based systemic delivery vehicles and method for selectively targeting an active agent to a specific tissue site. The methods include designing a lipid-based systemic delivery vehicle having a plurality of constitutent parts, and thereafter varying the amounts of each of the plurality of constituent parts to impart tissue selectivity. After tissue selectivity is imparted it is possible to selectively target an active agent to a specific tissue site.

公开(公告)号：EP1023048A1

公开(公告)日：2000-08-02

申请号：EP98957320.9

申请日：1998-10-09

申请人： Inex Pharmaceuticals Corp. ,  Saravolac, Edward G. ,  Zhang, Yuan-Peng ,  Wheeler, Jeffery J. ,  Cullis, Pieter R. ,  Scherrer, Peter ,  Kojic, Ljiljana D. ,  Ludkovski, Olga

发明人： SARAVOLAC, Edward, G. ,  ZHANG, Yuan-Peng ,  WHEELER, Jeffery, J. ,  CULLIS, Pieter, R. ,  SCHERRER, Peter ,  KOJIC, Ljiljana, D. ,  LUDKOVSKI, Olga

IPC分类号： A61K9/127 ,  C12N15/88

CPC分类号： A61K48/0025 ,  A61K9/1272 ,  A61K48/0008 ,  A61K48/0041

摘要： The present invention relates to lipid-based formulations for nucleic acid delivery to cells, methods for the preparation of such formulations and, in particular, to lipid encapsulated plasmids. The compositions are safe and practical for clinical use. In addition, the present invention provides methods for introducing nucleic acids into cells and for inhibiting tumor growth in cells using such lipid-nucleic acid formulations.

公开(公告)号：EP1212085B1

公开(公告)日：2007-10-31

申请号：EP00956004.6

申请日：2000-08-28

申请人： INEX Pharmaceuticals Corp.

发明人： SEMPLE, Sean, C. ,  HARASYM, Troy, O. ,  KLIMUK, Sandra, K. ,  KOJIC, Ljiljiana, D. ,  BRAMSON, Jonathan, L. ,  MUI, Barbara ,  HOPE, Michael, J.

IPC分类号： A61K39/39 ,  A61K31/7088 ,  A61K9/127 ,  A61P37/04 ,  A61K35/00

CPC分类号： A61K31/7088 ,  A61K9/1272 ,  A61K31/711 ,  A61K31/7125 ,  A61K39/39 ,  A61K2039/55555 ,  A61K2039/55561 ,  C12N2310/18

公开(公告)号：EP1328254B1

公开(公告)日：2007-02-21

申请号：EP01983342.5

申请日：2001-10-25

申请人： THE UNIVERSITY OF BRITISH COLUMBIA ,  INEX Pharmaceuticals Corp.

发明人： CULLIS, Pieter, R. ,  MACLACHLAN, Ian ,  FENSKE, David, B.

IPC分类号： A61K9/127

CPC分类号： A61K9/1272

摘要： The present invention provides lipid-based systemic delivery vehicles and method for selectively targeting an active agent to a specific tissue site. The methods include designing a lipid-based systemic delivery vehicle having a plurality of constitutent parts, and thereafter varying the amounts of each of the plurality of constituent parts to impart tissue selectivity. After tissue selectivity is imparted it is possible to selectively target an active agent to a specific tissue site.

公开(公告)号：EP1100834B1

公开(公告)日：2006-06-28

申请号：EP99920057.9

申请日：1999-04-27

申请人： INEX Pharmaceuticals Corp. ,  Chen, Tao ,  He, Yuehua ,  Cullis, Peter ,  Madden, Thomas ,  Scherrer, Peter ,  Kim, Jung Soo ,  Tirrell, David ,  Joshi, Phalgun

发明人： CHEN, Tao ,  HE, Yuehua ,  CULLIS, Peter ,  MADDEN, Thomas ,  SCHERRER, Peter ,  KIM, Jung Soo ,  TIRRELL, David ,  JOSHI, Phalgun

IPC分类号： C08F8/32 ,  C08F8/34 ,  A61K9/127

CPC分类号： A61K9/1271 ,  C08F8/12 ,  C08F8/30 ,  C08F8/32 ,  C08F120/06 ,  C08F297/026

摘要： The present invention relates generally to the amphiphilic polyelectrolyte, poly(2-ethylacrylic acid) and covalently bonded lipids to generate Lipo-PEAA. These Lipo-PEAA are then used to make pH-sensitive liposomes which become unstable, permeable or fusogenic with certain pH changes. In addition, this invention generally describes methods for delivering therapeutic compounds and drugs to target cells by administering to a host the pH-sensitive liposomes of the present invention.

公开(公告)号：EP1299084A2

公开(公告)日：2003-04-09

申请号：EP01949141.4

申请日：2001-06-29

申请人： Inex Pharmaceuticals Corp.

发明人： MADDEN, Thomas, D. ,  SEMPLE, Sean, C. ,  AHKONG, Quet, F.

IPC分类号： A61K9/127 ,  A61K31/47

CPC分类号： A61K9/127 ,  A61K9/1272 ,  A61K9/1278 ,  A61K31/4745 ,  A61K45/06 ,  A61K2300/00

摘要： This invention relates to liposomal antineoplastic agents (e.g., camptothecin) compositions and methods of using such compositions for treating neoplasia and for inhibiting angiogenesis. The compositions and methods are useful for modulating the plasma circulation half-life of an active agent.

公开(公告)号：EP1194122A1

公开(公告)日：2002-04-10

申请号：EP00949026.9

申请日：2000-07-14

申请人： Inex Pharmaceuticals Corp.

发明人： MAURER, Norbert ,  WONG, Kim, F. ,  CULLIS, Pieter, R.

IPC分类号： A61K9/127

CPC分类号： A61K9/1278 ,  A61K9/1272 ,  A61K9/1277

摘要： Fully lipid-encapsulated therapeutic agent particles of a charged therapeutic agent are prepared by combining a lipid composition containing preformed lipid vesicles, a charged therapeutic agent, and a destabilizing agent to form a mixture of preformed vesicles and therapeutic agent in a destabilizing solvent. The destabilizing solvent is effective to destabilize the membrane of the preformed lipid vesicles without disrupting the vesicles. The resulting mixture is incubated for a period of time sufficient to allow the encapsulation of the therapeutic agent within the preformed lipid vesicles. The destabilizing agent is then removed to yield fully lipid-encapsulated therapeutic agent particles. The preformed lipid vesicles comprise a charged lipid which has a charge which is opposite to the charge of the charged therapeutic agent and a modified lipid having a steric barrier moiety for control of aggregation.

公开(公告)号：EP0998306A1

公开(公告)日：2000-05-10

申请号：EP98936039.1

申请日：1998-07-23

申请人： Inex Pharmaceuticals Corp. ,  RIBOZYME PHARMACEUTICALS, INC.

发明人： KLIMUK, Sandra ,  SCHERRER, Peter ,  HOPE, Michael, J. ,  ZHANG, Yuan-Peng ,  REYNOLDS, Mark ,  MIN, John ,  SEMPLE, Sean

IPC分类号： A61K47/48

CPC分类号： A61K9/1272 ,  A61K47/60

摘要： The present invention relates to compositions and methods for delivering nucleic acid catalysts e.g., vasculor endothelial growth factor receptor (VEGF-R-1) ribozyme, into a biological system.