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    AMIDO-THIOPHENE COMPOUNDS AND THEIR USE
    3.
    发明公开
    AMIDO-THIOPHENE COMPOUNDS AND THEIR USE 有权
    酰胺 - 噻吩化合物及其用途

    公开(公告)号：EP2283004A1

    公开(公告)日：2011-02-16

    申请号：EP09718896.5

    申请日：2009-03-13

    申请人： THE UNIVERSITY OF EDINBURGH

    发明人： WEBSTER, Scott, Peter ,  SECKL, Jonathan, Robert ,  WALKER, Brian, Robert ,  WARD, Peter ,  PALLIN, Thomas, David ,  DYKE, Hazel, Joan ,  PERRIOR, Trevor, Robert

    IPC分类号： C07D333/38 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  A61K31/381

    CPC分类号： C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D487/04 ,  C07D487/08

    摘要： The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that,
    inter alia , inhibit 11 β-hydroxysteroid dehydrogenase type 1 (11 β-HSD1 ). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both
    in vitro and
    in vivo , to inhibit 11 β-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11 β-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.

    摘要翻译： 本发明一般涉及治疗性化合物领域。 更具体地说，本发明涉及特别是抑制11型β-羟类固醇脱氢酶1型（11β-HSD1）的某些酰胺 - 噻吩化合物。 本发明还涉及包含此类化合物的药物组合物，以及这些化合物和组合物在体外和体内用于抑制11型β-羟基类固醇脱氢酶; 用于治疗通过抑制11型β-羟类固醇脱氢酶1而改善的病症; 以治疗代谢综合征，其包括诸如2型糖尿病和肥胖症之类的疾病以及包括胰岛素抵抗，高血压，血脂障碍和心血管病症例如缺血性（冠状）心脏病的相关病症; 治疗中枢神经系统疾病，如轻度认知障碍和早期痴呆，包括阿尔茨海默病; 等等

    AMIDO-THIOPHENE COMPOUNDS AND THEIR USE AS 11-BETA-HSD1 INHIBITORS
    5.
    发明公开
    AMIDO-THIOPHENE COMPOUNDS AND THEIR USE AS 11-BETA-HSD1 INHIBITORS 审中-公开
    酰胺 - 噻吩化合物及其作为11-β-HSD1抑制剂的用途

    公开(公告)号：EP2229374A1

    公开(公告)日：2010-09-22

    申请号：EP08859744.8

    申请日：2008-12-11

    申请人： THE UNIVERSITY OF EDINBURGH

    发明人： WEBSTER, Scott, Peter ,  SECKL, Jonathan, Robert ,  WALKER, Brian, Robert ,  WARD, Peter ,  PALLIN, Thomas, David ,  DYKE, Hazel, Joan ,  PERRIOR, Trevor, Robert

    IPC分类号： C07D333/38 ,  C07D409/06 ,  C07D409/14 ,  C07D413/14 ,  C07D453/02 ,  C07D471/04 ,  A61K31/381 ,  A61P3/10

    CPC分类号： C07D333/38 ,  C07D409/06 ,  C07D409/14 ,  C07D413/14 ,  C07D453/02 ,  C07D471/04

    摘要： The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 11β-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11β-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc. Formula (I).

    摘要翻译： 本发明一般涉及治疗性化合物领域。 更具体地说，本发明涉及某些特别是抑制11β-羟基类固醇脱氢酶1型（11β-HSD1）的酰胺 - 噻吩化合物。 本发明还涉及包含此类化合物的药物组合物，以及这些化合物和组合物在体外和体内用于抑制1型11β-羟基类固醇脱氢酶; 治疗通过抑制1型11β-羟基类固醇脱氢酶而改善的疾病; 以治疗代谢综合征，其包括诸如2型糖尿病和肥胖症之类的疾病以及包括胰岛素抵抗，高血压，血脂障碍和心血管病症例如缺血性（冠状）心脏病的相关病症; 治疗中枢神经系统疾病，如轻度认知障碍和早期痴呆，包括阿尔茨海默病; 等式（I）。