-
1.发明授权PROGESTOGEN-FREE FORMULATIONS OF GnRH AND ESTROGEN FOR TREATING BENIGN GYNECOLOGICAL DISORDERS 失效促性腺激素释放激素和雌激素的良性妇科疾病的治疗孕激素-FREE配方
公开(公告)号：EP0748190B1
公开(公告)日：2003-07-30
申请号：EP94917349.6
申请日：1994-05-12
CPC分类号： A61K9/1647 , A61K9/0036 , A61K38/09 , Y10S424/14 , A61K31/567 , A61K31/566 , A61K31/565 , A61K2300/00
摘要： Compositions and methods which are effective to treat benign gynecological disorders for extended periods of time in women in who the risk of endometrial stimulations is minimized or absent are described, wherein an effective amount of a gonadotropin hormone releasing hormone composition and an effective amount of an estrogenic composition are provided over a period of time, optionally with addition of an androgenic composition.
-
2.发明公开
公开(公告)号：EP0538443A1
公开(公告)日：1993-04-28
申请号：EP92910686.0
申请日：1992-04-10
CPC分类号： A61K38/09 , A61K9/0036 , A61K9/1647 , Y10S424/14 , Y10S514/80 , Y10S514/841 , Y10S514/842 , Y10S514/843 , Y10S530/85 , Y10S530/853 , A61K31/57 , A61K31/565 , A61K31/05 , A61K2300/00
摘要： Compositions et procédés efficaces pour la contraception et pour le traitement de troubles gynécologiques bénins pendant des périodes de temps prolongées. Une quantité efficace d'une composition hormonale libérant l'hormone de gonadotropine et une quantité efficace d'une composition oestrogène sont administrées pendant une première période de temps, en plus d'une composition progestogène et éventuellement androgène. Selon un protocole, la progestogène est administrée pendant une seconde période de temps plus courte; la progestogène est administrée à un niveau plus élevé pendant au moins 5 à 20 jours environ puis, s'il y a lieu, à un niveau plus faible pendant le reste de la seconde période de temps. Selon une variante du protocole, la progestogène est administrée à un niveau plus faible pratiquement toute la période d'administration de la composition hormonale de libération de l'hormone gonadotropine et de la composition oestrogène. Une quantité efficace de l'hormone androgène est éventuellement administrée pendant la première période de temps.
-
3.发明授权
公开(公告)号：EP0538443B1
公开(公告)日：1997-10-01
申请号：EP92910686.2
申请日：1992-04-10
IPC分类号： A61K9/14
CPC分类号： A61K38/09 , A61K9/0036 , A61K9/1647 , Y10S424/14 , Y10S514/80 , Y10S514/841 , Y10S514/842 , Y10S514/843 , Y10S530/85 , Y10S530/853 , A61K31/57 , A61K31/565 , A61K31/05 , A61K2300/00
摘要： Compositions and methods which are effective to inhibit conception and to treat benign gynecological disorders for extended periods of time are described, wherein an effective amount of a gonadotropin hormone releasing hormone composition and an effective amount of an estrogenic composition are provided over a first period of time, in addition to a progestogen and optionally an androgenic composition. According to one protocol, the progestogen is provided for a second, shorter period of time; the progestogen is provided at a higher level for at least 5 to about 20 days, and then at a lower level for the remainder, if any, of the second period of time. In an alternative protocol, the progestogen is provided at a lower level substantially throughout the period of administration of gonadotropin hormone releasing hormone composition and estrogenic composition. An effective amount of the androgenic hormone is optionally provided over the first period of time.
-
4.发明公开METHODS AND FORMULATIONS FOR USE IN TREATING OOPHORECTOMIZED WOMEN 失效方法和LÖSUGEN对于女性OOPHOREKTOMIERTEN的治疗
公开(公告)号：EP0748191A1
公开(公告)日：1996-12-18
申请号：EP94917357.0
申请日：1994-05-12
CPC分类号： A61K31/565 , A61K9/0036 , A61K9/1647 , A61K31/57 , A61K38/09 , A61K2300/00
摘要： Compositions and methods which are effective to prevent symptoms of loss of ovarian function (e.g., in oophorectomized women) over a period of time are described, consisting essentially of an effective amount of an estrogenic composition and an effective amount of an androgenic composition. The levels of estrogens and androgens employed are sufficient to reduce bone mineral density loss and minimize other side effects observed after oophorectomy, and at such low doses as to minimize any adverse impact on the patient's long-term prognosis or (in the case of testosterone) result in additional side effects.
-
5.发明公开
公开(公告)号：EP0748190A1
公开(公告)日：1996-12-18
申请号：EP94917349.0
申请日：1994-05-12
CPC分类号： A61K9/1647 , A61K9/0036 , A61K38/09 , Y10S424/14 , A61K31/567 , A61K31/566 , A61K31/565 , A61K2300/00
摘要： Compositions and methods which are effective to treat benign gynecological disorders for extended periods of time in women in who the risk of endometrial stimulations is minimized or absent are described, wherein an effective amount of a gonadotropin hormone releasing hormone composition and an effective amount of an estrogenic composition are provided over a period of time, optionally with addition of an androgenic composition.
-
-
-
-
搜索结果
5 条记录 (耗时 0.011 秒)
