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公开(公告)号：EP1689698A1
公开(公告)日：2006-08-16
申请号：EP04797019.9
申请日：2004-11-12
发明人： WIDMER, Alfred, Werner , JOLLIFFE, Katrina, Anne , WRIGHT, Lesley, Catherine , SORRELL, Tania, Christine
IPC分类号： C07C211/63 , C07C237/08 , C07D213/04 , C07D233/64 , C07D295/037 , C07D453/02 , C07F9/54 , A61K31/14 , A61K31/66 , A61P31/04 , A61P31/12 , A61P33/00
CPC分类号： C07D233/64 , C07C211/63 , C07C237/08 , C07D211/64 , C07D213/04 , C07D265/30 , C07D295/13 , C07D453/02 , C07F9/5428 , C07F9/5449
摘要： The present invention relates to bis-cationic compounds comprising quaternary ammonium groups and/or quaternary phosphonium groups. The invention also relates to the use of bis-cationic compounds as Phospholipase B inhibitors and the use of bis cationic compounds for the treatment or prevention of microbial infection.
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公开(公告)号：EP2016069A1
公开(公告)日：2009-01-21
申请号：EP07718841.5
申请日：2007-05-04
IPC分类号： C07D401/06 , A61P31/02 , A61P31/12 , A01N43/40 , A61P31/04 , A61P33/00 , A61K31/4425 , A61P31/10 , C07D401/12
CPC分类号： A61K31/444 , A61K31/4425 , C07D213/06 , C07D213/30 , C07D213/50 , C07D213/55 , C07D401/14
摘要： A method of treating, inhibiting, or preventing an infection in a subject is described. The method comprises administering to the subject an effective amount of at least one bis-pyridinium compound. The bis-pyridinium compound comprises two aromatic ring structures. Each of the ring structures comprises a pyridine ring, and the ring structures are linked by a linker group of at least 8 atoms in length, said linker group being attached to the nitrogen atoms of the pyridine rings. At least one substituent on at least one of the ring structures is an alkyl group having at least 2 carbon atoms, and no substituent on either of the ring structures is -OH, -SH or an amine group.
摘要翻译： 描述了治疗，抑制或预防受试者感染的方法。 该方法包括向受试者施用有效量的至少一种双吡啶鎓化合物。 双吡啶鎓化合物包含两个芳香环结构。 每个环结构包含吡啶环，并且环结构通过至少8个原子长度的连接基团连接，所述连接基团连接到吡啶环的氮原子上。 在至少一个环结构上的至少一个取代基是具有至少2个碳原子的烷基，并且在任一环结构上没有取代基是-OH，-SH或胺基。
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