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8 条记录 (耗时 0.014 秒)

    Preparing 7-halo-7-deoxylincomycins
    1.
    发明公开
    Preparing 7-halo-7-deoxylincomycins 失效
    Herstellung von 7-卤代7-脱氧霉素。

    公开(公告)号：EP0183505A2

    公开(公告)日：1986-06-04

    申请号：EP85308539.7

    申请日：1985-11-25

    申请人： THE UPJOHN COMPANY

    发明人： Livingston, Douglas Alan ,  Petre, Janet Elizabeth

    IPC分类号： C07H15/16

    CPC分类号： C07H15/16

    摘要： A process for preparing a 7-halodeoxylincomycin or an analogue thereof, which comprises reacting lincomycin or an analogue thereof with a thionyl halide and dimethylformamide, under mild conditions.

    摘要翻译： 一种制备7-卤代脱氧霉菌素或其类似物的方法，其包括在温和条件下使林可霉素或其类似物与亚硫酰卤和二甲基甲酰胺反应。

    Preparing clindamycin and analogues thereof
    5.
    发明公开
    Preparing clindamycin and analogues thereof 失效
    Herstellung von Clindamycin und Analoge。

    公开(公告)号：EP0161794A2

    公开(公告)日：1985-11-21

    申请号：EP85302494.1

    申请日：1985-04-09

    申请人： THE UPJOHN COMPANY

    发明人： Livingston, Douglas Alan

    IPC分类号： C07H15/16

    CPC分类号： C07D295/067 ,  C07H15/16

    摘要： A process for preparing 7-halo-7-deoxylincomycin or an analogue thereof, which comprises

    (a) reacting a starting compound selected from lincomycin and analogues thereof, with an amide halide having the formula
    wherein each Hal is bromine or chlorine, and either R i and R 2 are independently selected from aryl and C 1-8 alkyl or NR 1 R 2 is morpholino or a heterocyclic ring containing 4 to 8 ring atoms selected from carbon and nitrogen, to form an adduct;
    (b) heating the adduct, to form a 7-halo-7-deoxy adduct; and
    (c) hydrolysing the 7-halo-7-deoxy adduct with an aqueous base.

    摘要翻译： 一种制备7-卤代-7-脱氧霉菌素或其类似物的方法，其包括：（a）使选自林可霉素及其类似物的起始化合物与具有下式的酰胺卤化物反应其中每个Hal为溴 或氯，并且R 1和R 2独立地选自芳基和C 1-8烷基或NR 1 R 2是吗啉代或含有4至8个选自碳和氮的环原子的杂环，以形成加合物;（b）加热加合物 ，以形成7-卤代-7-脱氧加合物; 和（c）用碱水溶液水解7-卤代-7-脱氧加合物。

    Preparing clindamycin and analogues thereof
    6.
    发明公开
    Preparing clindamycin and analogues thereof 失效
    制备白蛋白及其类似物

    公开(公告)号：EP0161794A3

    公开(公告)日：1987-07-29

    申请号：EP85302494

    申请日：1985-04-09

    申请人： THE UPJOHN COMPANY

    发明人： Livingston, Douglas Alan

    IPC分类号： C07H15/16 ,  C07C119/18 ,  C07D295/18

    CPC分类号： C07D295/067 ,  C07H15/16

    摘要： A process for preparing 7-halo-7-deoxylincomycin or an analogue thereof, which comprises
    (a) reacting a starting compound selected from lincomycin and analogues thereof, with an amide halide having the formula
    wherein each Hal is bromine or chlorine, and either R i and R 2 are independently selected from aryl and C 1-8 alkyl or NR 1 R 2 is morpholino or a heterocyclic ring containing 4 to 8 ring atoms selected from carbon and nitrogen, to form an adduct; (b) heating the adduct, to form a 7-halo-7-deoxy adduct; and (c) hydrolysing the 7-halo-7-deoxy adduct with an aqueous base.