公开(公告)号：EP3294705A1

公开(公告)日：2018-03-21

申请号：EP16793664

申请日：2016-05-14

申请人： THE WISTAR INST OF ANATOMY AND BIOLOGY

发明人： MESSICK TROY E ,  SMITH GARRY R ,  REITZ ALLEN B ,  LIEBERMAN PAUL M ,  MCDONNELL MARK E ,  ZHANG YAN ,  CARLSEN MARIANNE ,  CHEN SHUAI

IPC分类号： C07C311/16 ,  C07C255/55

CPC分类号： C07D209/08 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D417/12 ,  C07D471/08 ,  C07D487/08

摘要： The present invention provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by EBNA1 activity, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The present invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection.