公开(公告)号：EP3294705A1

公开(公告)日：2018-03-21

申请号：EP16793664

申请日：2016-05-14

申请人： THE WISTAR INST OF ANATOMY AND BIOLOGY

发明人： MESSICK TROY E ,  SMITH GARRY R ,  REITZ ALLEN B ,  LIEBERMAN PAUL M ,  MCDONNELL MARK E ,  ZHANG YAN ,  CARLSEN MARIANNE ,  CHEN SHUAI

IPC分类号： C07C311/16 ,  C07C255/55

CPC分类号： C07D209/08 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D417/12 ,  C07D471/08 ,  C07D487/08

摘要： The present invention provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by EBNA1 activity, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The present invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection.

公开(公告)号：EP3068758A4

公开(公告)日：2017-08-30

申请号：EP14861658

申请日：2014-11-14

申请人： THE WISTAR INST OF ANATOMY AND BIOLOGY

发明人： MESSICK TROY E ,  SMITH GARRY R ,  REITZ ALLEN B ,  LIEBERMAN PAUL M

IPC分类号： C07C229/56

CPC分类号： C07D207/327 ,  C07C53/18 ,  C07C63/66 ,  C07C65/19 ,  C07C65/28 ,  C07C211/27 ,  C07C217/84 ,  C07C229/56 ,  C07C229/64 ,  C07C233/11 ,  C07C233/64 ,  C07C233/65 ,  C07C235/58 ,  C07C255/54 ,  C07C255/55 ,  C07C311/08 ,  C07C311/16 ,  C07C311/17 ,  C07C317/14 ,  C07C317/44 ,  C07C2601/02 ,  C07D207/08 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D209/08 ,  C07D211/70 ,  C07D213/55 ,  C07D213/64 ,  C07D213/74 ,  C07D215/14 ,  C07D231/12 ,  C07D235/06 ,  C07D239/26 ,  C07D249/06 ,  C07D277/30 ,  C07D295/155 ,  C07D307/79 ,  C07D333/54 ,  C07D401/04 ,  C07D401/10 ,  C07D403/10 ,  C07D409/10 ,  C07D417/10 ,  C07D471/04 ,  C07D487/04

摘要： The invention provides EBNA1 inhibitors, and pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by EBNA1 activity such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The compounds and compositions of the invention are further useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection. The compounds and compositions of the invention are further useful for the treatment of diseases caused by lytic EBV infection.

摘要翻译： 本发明提供了EBNA1抑制剂及包含其的药物组合物，其可用于治疗由EBNA1活性引起的疾病，所述疾病例如但不限于癌症，传染性单核细胞增多症，慢性疲劳综合征，多发性硬化症，系统性红斑狼疮和/ 或类风湿性关节炎。 本发明的化合物和组合物还可用于治疗潜伏性EB病毒（EBV）感染引起的疾病。 本发明的化合物和组合物还可用于治疗由溶解性EBV感染引起的疾病。