公开(公告)号：EP0478146B1

公开(公告)日：1996-04-10

申请号：EP91307957.0

申请日：1991-08-30

申请人： THE WISTAR INSTITUTE

发明人： Linnenbach, Alban ,  Koprowski, Hilary ,  Szala, Stanislaw

IPC分类号： C12N15/12 ,  C12P21/02 ,  C07K14/705 ,  C07K16/30

CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K16/3046 ,  Y02A50/423 ,  Y02A50/473

摘要： The human tumor-associated antigen CO-029 is a monoclonal antibody-defined, 27-30 kDa cell surface glycoprotein. A full-length cDNA clone for CO-029 is described. When transiently expressed in COS cells, the cDNA clone direct the synthesis of an antigen reactive with monoclonal antibody CO-029 in mixed hemadsorption and immunoblot assays. Sequence analysis reveals that CO-029 belongs to a family of cell surface antigens which includes the melanoma-associated antigen ME491, the leukocyte cell surface antigen CD37, and the Sm23 antigen of the parasitic helminth Schistosoma mansoni.

公开(公告)号：EP0478146A1

公开(公告)日：1992-04-01

申请号：EP91307957.0

申请日：1991-08-30

申请人： THE WISTAR INSTITUTE

发明人： Linnenbach, Alban ,  Koprowski, Hilary ,  Szala, Stanislaw

IPC分类号： C12N15/12 ,  C12P21/02 ,  C07K14/705 ,  C07K16/30

CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K16/3046 ,  Y02A50/423 ,  Y02A50/473

摘要： The human tumor-associated antigen CO-029 is a monoclonal antibody-defined, 27-30 kDa cell surface glycoprotein. A full-length cDNA clone for CO-029 is described. When transiently expressed in COS cells, the cDNA clone direct the synthesis of an antigen reactive with monoclonal antibody CO-029 in mixed hemadsorption and immunoblot assays. Sequence analysis reveals that CO-029 belongs to a family of cell surface antigens which includes the melanoma-associated antigen ME491, the leukocyte cell surface antigen CD37, and the Sm23 antigen of the parasitic helminth Schistosoma mansoni .

摘要翻译： 人肿瘤相关抗原CO-029是单克隆抗体定义的27-30kDa细胞表面糖蛋白。 描述了CO-029的全长cDNA克隆。 当在COS细胞中瞬时表达时，cDNA克隆在混合血液吸收和免疫印迹测定中指导与单克隆抗体CO-029反应的抗原的合成。 序列分析显示，CO-029属于细胞表面抗原家族，其包括黑素瘤相关抗原ME491，白细胞表面抗原CD37和寄生蠕虫血吸虫血吸虫的Sm23抗原。