公开(公告)号：EP2199402A4

公开(公告)日：2011-07-06

申请号：EP08783682

申请日：2008-09-08

申请人： TIANJIN INST PHARM RESEARCH

发明人： HAN YINGMEI ,  XIA GUANGPING ,  XU WEIREN ,  ZHAO ZHUANYOU ,  LIU WULIN ,  ZHAO NAXIA ,  LIU PENG ,  ZHANG SHIJUN ,  WANG YULI ,  WANG WEITING ,  TANG LIDA ,  FU XIAOLI

IPC分类号： C12P19/56 ,  A61K9/00 ,  A61K9/08 ,  A61K9/12 ,  A61K9/19 ,  A61K31/7048 ,  A61K36/481 ,  A61P9/00 ,  C07H17/04

CPC分类号： A61K36/481 ,  A61K31/7048 ,  C07J17/005 ,  C12P19/56

摘要： This invention provides a method for preparing cycloastragenol monoglucoside CMG (cydoastragenol-6-O-²-D-glucoside), comprising the steps of: a. using astragaloside IV or Astragali extracts prepared by a conventional method as raw materials and adding an appropriate solvent thereinto to form a raw material solution; b. adding hydrolase and allowing for hydrolysis at a constant temperature to obtain a hydrolysate; c. separating the hydrolysate with macroporous adsorption resin; and d. obtaining the product by purification and separation. The present invention further provides cycloastragenol-6-O-²-D-glucoside prepared according to the method of this invention as well as its use in the preparation of a medicament for treating cardiovascular diseases and pharmaceutical compositions comprising the same.