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1.发明授权Calcium-phosphate type hydroxyapatite for chromatographic separation and process for producing it 失效用于色谱分离的钙磷酸盐类型的羟基磷酸酯及其制备方法
公开(公告)号：EP0217614B1
公开(公告)日：1990-09-05
申请号：EP86307256.7
申请日：1986-09-22
发明人： Tagaya, Nobuaki , Kuwahara, Hideyuki , Hashimoto, Takao , Komatsu, Noriko , Fukamachi, Keiko , Maeshima, Tsugio , Ishikawa, Toshihiro , Ogawa, Tetsuro
CPC分类号： B01J20/048 , B01J20/282 , B01J2220/54 , C01B25/32 , C01B25/322
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2.发明公开Calcium-phosphate type hydroxyapatite for chromatographic separation and process for producing it 失效羟基磷灰石的磷酸钙型色谱分离和程序及其制备。
公开(公告)号：EP0217614A2
公开(公告)日：1987-04-08
申请号：EP86307256.7
申请日：1986-09-22
发明人： Tagaya, Nobuaki , Kuwahara, Hideyuki , Hashimoto, Takao , Komatsu, Noriko , Fukamachi, Keiko , Maeshima, Tsugio , Ishikawa, Toshihiro , Ogawa, Tetsuro
CPC分类号： B01J20/048 , B01J20/282 , B01J2220/54 , C01B25/32 , C01B25/322
摘要： The calcium-phosphate type hydroxyapatite is in the form of spherulites having a mean particle diameter of 0.5 to 50 µm and preferably 1 to 10 µm. The spherulites are aggregates mainly of acicular crystallites belonging to a series of hexagonal systems and having unit lattice constants of 9.58± 0.08 A (0.958±0.008 nm) for the a axis and 7.00 0.05 A (0.700±0.005 nm) for the c axis. The spherulitic hydroxyapatite is produced by granulating a calcium-phosphate type hydroxyapatite in the form of a gel and then firing the granular apatite at 400 to 700°C, preferably at 500 to 600 C and desirably in the presence of oxygen or air.
摘要翻译： 的磷酸钙型羟基磷灰石是具有0.5至50微米的平均粒径，优选为1至10微米球粒形式。 该球粒由针状结晶属于一系列六方晶系的，并具有+/- 9:58 0:08 A（0.958 +/- 0.008纳米）的a轴和7点00 +/- 0.05埃（的单位晶格常数主要吸住的聚集体0.700 + / -0005纳米）为c轴。 球晶的羟基磷灰石是通过在凝胶形式粒化磷酸钙型羟基磷灰石，然后烧制该粒状磷灰石在400〜700℃，优选在500〜600℃和优选在氧气或空气的存在下制备。
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3.发明公开Calcium-phosphate type hydroxyapatite for chromatographic separation and process for producing it 失效用于色谱分离的钙磷酸酯类型的羟基磷酸酯及其生产方法
公开(公告)号：EP0217614A3
公开(公告)日：1987-09-30
申请号：EP86307256
申请日：1986-09-22
发明人： Tagaya, Nobuaki , Kuwahara, Hideyuki , Hashimoto, Takao , Komatsu, Noriko , Fukamachi, Keiko , Maeshima, Tsugio , Ishikawa, Toshihiro , Ogawa, Tetsuro
CPC分类号： B01J20/048 , B01J20/282 , B01J2220/54 , C01B25/32 , C01B25/322
摘要： The calcium-phosphate type hydroxyapatite is in the form of spherulites having a mean particle diameter of 0.5 to 50 µm and preferably 1 to 10 µm. The spherulites are aggregates mainly of acicular crystallites belonging to a series of hexagonal systems and having unit lattice constants of 9.58± 0.08 A (0.958±0.008 nm) for the a axis and 7.00 0.05 A (0.700±0.005 nm) for the c axis. The spherulitic hydroxyapatite is produced by granulating a calcium-phosphate type hydroxyapatite in the form of a gel and then firing the granular apatite at 400 to 700°C, preferably at 500 to 600 C and desirably in the presence of oxygen or air.
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4.发明公开Assemblage of hydroxyl apatite particles and liquid chromatography column using the same 失效使用该化合物的羟基APATITE颗粒和液相色谱柱的组装
公开(公告)号：EP0239970A3
公开(公告)日：1988-04-20
申请号：EP87104683
申请日：1987-03-30
发明人： Tagaya, Nobuaki , Kuwahara, Hideyuki , Hashimoto, Takao , Komatsu, Noriko , Fukamachi, Keiko , Maejima, Tsugio , Tamai, Kimio , Kanakubo, Tetsuo , Yosizawa, Masao
CPC分类号： B01J20/282 , B01J20/048 , B01J20/28004 , B01J20/28019 , B01J20/3085 , B01J2220/52
摘要： An assemblage of hydroxyl apatite particles having small and uniform particle size is described. The median of the particles size is 1 to 10 µm, and at least 90 % of the particles in the assemblage have a particle size of not more than 25 µm. The assemblage has a use as a packing of a liquid chromatography column.
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5.发明公开Assemblage of hydroxyl apatite particles and liquid chromatography column using the same 失效羟基磷灰石颗粒的汇编和它们在液相色谱柱使用。
公开(公告)号：EP0239970A2
公开(公告)日：1987-10-07
申请号：EP87104683.5
申请日：1987-03-30
发明人： Tagaya, Nobuaki , Kuwahara, Hideyuki , Hashimoto, Takao , Komatsu, Noriko , Fukamachi, Keiko , Maejima, Tsugio , Tamai, Kimio , Kanakubo, Tetsuo , Yosizawa, Masao
CPC分类号： B01J20/282 , B01J20/048 , B01J20/28004 , B01J20/28019 , B01J20/3085 , B01J2220/52
摘要： An assemblage of hydroxyl apatite particles having small and uniform particle size is described. The median of the particles size is 1 to 10 µm, and at least 90 % of the particles in the assemblage have a particle size of not more than 25 µm. The assemblage has a use as a packing of a liquid chromatography column.
摘要翻译： 具有小而均匀的粒度的羟基磷灰石颗粒的集合体进行说明。 颗粒大小的中值是1-10微米，并且至少90％的组合的颗粒具有不大于25微米的颗粒尺寸。 组合件有一个用作液相色谱柱的填充物。
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公开(公告)号：EP0216621A3
公开(公告)日：1987-09-30
申请号：EP86307257
申请日：1986-09-22
发明人： Tagaya, Nobuaki , Kuwahara, Hideyuki , Hashimoto, Takao , Komatsu, Noriko , Fukamachi, Keiko , Maeshima, Tsugio
CPC分类号： B01J20/048 , B01J20/282 , C01B25/32 , C01B25/322 , Y10S435/815
摘要： A calcium-phosphate type hydroxyapatite belongs to a series of hexagonal systems having unit lattice constants of 9.58±0.08 A (0.0958±0.008 nm) for the a axis and 7.00±0.05 A (0.700±0.005 nm) for the c axis. Its Ca/P ratio is in the range of 1.50 to 1.90. Its principal use is as a column packing material for chromatographic separation of biopolymers. The hydroxyapatite is produced byfiring it in the form of a gel or powder at a temperature of 400° to 700°C. the gel having the form of a suspension or slurry. A powder, however, is prepared by removing moisture from the hydroxyapatite in the gel form and then drying. Either gel or powder can be fired by heating in the presence of oxygen or air at 500° to 600°C.
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