专利检索 ap:("TOKO PHARMACEUTICAL IND CO LTD" OR "RES FOUND ITSUU LAB") AND inv:"NAGANO HIROO" 第 1 页

1.

发明公开
PROCESS FOR THE PRODUCTION OF CRYSTALS OF A BENZOIC ACID DERIVATIVE 有权
标题翻译：用于生产晶体衍生物BENZOIC

公开(公告)号：EP1314720A4

公开(公告)日：2004-08-18

申请号：EP01963406

申请日：2001-08-31

申请人： TOKO PHARMACEUTICAL IND CO LTD , RES FOUND ITSUU LAB

发明人： KAGECHIKA HIROYUKI , NAGANO HIROO

IPC分类号： C07C231/24 , C07C233/65 , C07C235/84

CPC分类号： C07C233/65 , C07C231/24 , C07C2602/10 , C07C235/84

摘要： A process for producing crystals of 4-[(5,6,7,8-tetra- hydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid exhibiting a single endothermic peak near 233°C in differential scanning calorimetry, which comprises the step of recrystallizing crystals of 4-[(5,6,7,8-tetrahydro-5,5,8,8 -tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid from a water-ethanol mixture. This process enables selective production of type II crystals stable to physical impact, and the obtained crystals are free from highly toxic hexane as the residual solvent, thus being suitably usable as an active ingredient in medicines.