公开(公告)号：EP1431269A4

公开(公告)日：2004-12-22

申请号：EP01972523

申请日：2001-09-27

Applicant: TOSOH F TECH INC

Inventor： KONDO NORIHISA ,  MIMURA HIDEYUKI ,  KAWADA KOSUKE ,  ARAI SHOJI

IPC: C07C67/54 ,  C07C69/716 ,  C07C67/307 ,  C07C67/58 ,  C07C69/72

CPC classification number: C07C67/54 ,  C07C69/716

Abstract: A method of separating a purified 2-fluoro-3-oxoalkylcarboxylic acid ester as a reaction product from a liquid reaction mixture obtained by fluorinating a 3-oxoalkylcarboxylic acid ester, characterized by comprising removing the hydrogen fluoride yielded as a by-product from the liquid reaction mixture and then separating the 2-fluoro-3-oxoalkylcarboxylic acid ester by distillation. Thus, a high-purity 2-fluoro-3-oxoalkylcarboxylic acid ester, which is useful as an intermediate for medicines and agricultural chemicals, can be separated from the liquid reaction mixture resulting from the fluorination of a 3-oxoalkylcarboxylic acid ester.

公开(公告)号：EP1903021A4

公开(公告)日：2010-06-09

申请号：EP06729640

申请日：2006-03-22

Applicant: TOSOH F TECH INC

Inventor： KONDO NORIHISA ,  WATANABE AKIO ,  KANEZAKI HIROKI ,  KAWADA KOSUKE

IPC: C07C17/16 ,  C07C19/08 ,  C07C23/08 ,  C07C23/38 ,  C07C67/307 ,  C07C69/63 ,  C07C69/65 ,  C07D207/16

CPC classification number: C07C67/307 ,  C07B39/00 ,  C07C17/16 ,  C07C2601/08 ,  C07C2603/74 ,  C07C19/08 ,  C07C23/38 ,  C07C23/08 ,  C07C69/65 ,  C07C69/63

公开(公告)号：EP1362842A4

公开(公告)日：2005-06-29

申请号：EP01272302

申请日：2001-12-25

Applicant: TOSOH F TECH INC

Inventor： KONDO NORIHISA ,  MIMURA HIDEYUKI ,  NUKUI KAZUNORI ,  KAWADA KOSUKE ,  ARAI SHOJI

IPC: C07C67/307 ,  C07C67/54 ,  C07C67/58 ,  C07C69/716 ,  C07C69/72 ,  C07C69/738

CPC classification number: C07C67/58 ,  C07C67/307 ,  C07C69/738 ,  C07C69/716

Abstract: A process for preparing 2-fluoro-3-oxoalkylcarboxylic acid esters by fluorinating a 3-oxoalkylcarboxylic acid ester with fluorine gas, characterized in that the concentration of the 3-oxoalkylcarboxylic acid ester in the reaction fluid is kept at 3 wt% or above; and a process for purifying 2-fluoro-3- oxoalkylcarboxylic acid esters, characterized by washing a product of fluorination of a 3-oxoalkylcarboxylic acid ester with at least thrice as much water as the substrate to thereby obtain a purified 2-fluoro-3-oxoalkylcarboxylic acid ester in a high yield. According to these processes, high-purity 2-fluoro-3-oxoalkylcarboxylic acid esters useful as intermediates for drugs or agricultural chemicals can be efficiently prepared through inhibition of by-product formation or efficient purification of products of fluorination of 3-oxoalkylcarboxylic acid esters.

Abstract translation: 其特征在于，反应液中的3-氧代烷基羧酸酯的浓度保持在3重量％以上，其特征在于，所述反应液中的3-氧代烷基羧酸酯的浓度为3重量％以上。 和纯化2-氟-3-氧代烷基羧酸酯的方法，其特征在于用至少为底物3倍的水洗涤3-氧代烷基羧酸酯的氟化产物，从而得到纯化的2-氟-3- 氧代烷基羧酸酯。 根据这些方法，通过抑制副产物形成或有效纯化3-氧代烷基羧酸酯的氟化产物，可以有效地制备用作药物或农药中间体的高纯度2-氟-3-氧代烷基羧酸酯。