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1.发明授权POTENTIATOR FOR NERVE GROWTH FACTOR ACTIVITY CONTAINING 1,2-ETHANEDIOL DERIVATIVE OR SALT THEREOF 失效1,2-乙二醇或其盐含有神经生长因子的活性增强剂
公开(公告)号：EP0790246B1
公开(公告)日：2002-01-16
申请号：EP95934859.0
申请日：1995-10-20
IPC分类号： C07D333/52 , A61K31/38 , A61K31/135 , A61K31/34 , A61K31/395 , A61K31/40 , A61K31/495 , A61K31/535 , C07D333/54
CPC分类号： C07D307/79 , C07C217/10 , C07D333/54 , C07D409/12 , C07D453/02 , C07D471/08 , Y02P20/55
摘要： A 1,2-ethanediol derivative represented by general formula (I) or a salt thereof (wherein R1 represents optionally substituted phenyl, naphthyl, indanyl, indenyl, tetrahydronaphthyl or heterocyclic group; R2 represents hydrogen, alkyl or a hydroxyl-protecting group; R3 represents hydrogen or lower alkyl; nR4s and nR5s represent each independently hydrogen or lower alkyl; R6 represents optionally substituted amino or a nitrogenous heterocyclic group, or ammonio; and n represents an integer of 0 to 6). The compound has an excellent effect of potentiating the nerve growth factor acivity and is useful as a remedy for various diseases caused by central or peripheral nervous system degeneration, such as senile dementia of Alzheimer type, Huntington's chorea, various types of neuropathy and Riley-Day syndrome, traumatic neurosis and amyotrophic lateral sclerosis (ALS).
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2.发明公开POTENTIATOR FOR NERVE GROWTH FACTOR ACTIVITY CONTAINING 1,2-ETHANEDIOL DERIVATIVE OR SALT THEREOF 失效1,2-ETHANDIOLDERDEAT ODAT DESSEN SALZ ENTHALTENDER电位器DERAKTIVITÄTDES NERVENWACHSTUMSFAKTORS
公开(公告)号：EP0790246A1
公开(公告)日：1997-08-20
申请号：EP95934859.0
申请日：1995-10-20
IPC分类号： C07D333/52 , A61K31/38 , A61K31/135 , A61K31/34 , A61K31/395 , A61K31/40 , A61K31/495 , A61K31/535
CPC分类号： C07D307/79 , C07C217/10 , C07D333/54 , C07D409/12 , C07D453/02 , C07D471/08 , Y02P20/55
摘要： A 1,2-ethanediol derivative represented by the general formula [I] or its salt:
has a NGF activity-potentiating effect and is useful as a remedy for various diseases caused by degeneration of central nervous system or peripheral nervous system such as senile dementia of Alzheimer type, Huntington's chorea, various neuropathies, Riley-Day syndrome, traumatic nerve injury, amyotrophic lateral sclerosis (ALS) and the like.摘要翻译： 由通式ÄIÜ表示的1,2-乙二醇衍生物或其盐：
具有NGF活性增强作用，可用作中枢神经系统或周围神经系统变性引起的各种疾病的补救剂，例如老年人 阿尔茨海默氏型痴呆，亨廷顿氏舞蹈病，各种神经病，莱利日综合征，创伤神经损伤，肌萎缩性侧索硬化（ALS）等。
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