公开(公告)号：EP1514542B1

公开(公告)日：2012-02-22

申请号：EP03760132.5

申请日：2003-04-03

申请人： TOYAMA CHEMICAL CO., LTD.

发明人： NAKADA, Yasushi ,  NAKAGAWA, Masaya ,  ONO, Satoshi

IPC分类号： A61K31/381 ,  A61K31/122 ,  A61K31/21 ,  A61K31/397 ,  A61K31/445 ,  A61K31/473 ,  A61K31/55 ,  A61K45/00 ,  A61P25/28 ,  A61P43/00

CPC分类号： A61K45/06 ,  A61K31/122 ,  A61K31/21 ,  A61K31/381 ,  A61K31/397 ,  A61K31/445 ,  A61K31/473 ,  A61K31/55 ,  A61K2300/00

摘要： When combined with a compound having an acetylcholine esterase inhibitory effect, an alkyl ether derivative represented by the following general formula [1] or its salt: [1] wherein R , R , R , R , m and n are each as defined in the description; synergistically enhances an anti-hypoxia effect. Thus, this combination is useful as a method of improving brain function. A medicinal composition containing the combination of the compounds as described above is useful in treating and preventing dysmnesia caused by intracerebral acetylcholine nerve hypofunction or selective cell death occurring in cerebrovascular dementia, senile dementia, Alzheimer's disease, after effect of ischemic encephalopathy and cerebral stroke.

公开(公告)号：EP1186594A1

公开(公告)日：2002-03-13

申请号：EP00935600.7

申请日：2000-06-09

申请人： TOYAMA CHEMICAL CO., LTD.

发明人： ONO, Satoshi ,  SAITOH, Akihito ,  IWAKAMI, Noboru ,  NAKAGAWA, Masaya ,  YAMAGUCHI, Sumie

IPC分类号： C07C217/10

CPC分类号： C07D235/06 ,  C07C217/10 ,  C07C2602/08 ,  C07D215/14 ,  C07D241/42 ,  C07D277/64 ,  C07D307/79 ,  C07D311/22 ,  C07D317/54 ,  C07D319/18 ,  C07D333/54 ,  C07D333/56 ,  C07D333/62 ,  C07D333/68

摘要： An N-alkoxyalkyl-N,N-dialkylamine derivative represented by the following general formula [1]:
wherein the ring D represents a 5- or 6-membered heterocyclic ring or hydrocarbon ring; R 3 and R 4 , which are the same or different, represent an unsubstituted or substituted alkyl, cycloalkyl or aralkyl group; and R 1 , R 2 , R 5 , R 6 , R 7 , R 8 , m and n are as defined in the specification, or a salt thereof has an anti-hypoxic activity, a nerve-protecting activity and a nerve regeneration promoting activity and is useful for the treatment of neurodegenerative diseases.

公开(公告)号：EP1186594B1

公开(公告)日：2009-08-05

申请号：EP00935600.7

申请日：2000-06-09

申请人： TOYAMA CHEMICAL CO., LTD.

发明人： ONO, Satoshi ,  SAITO, Akihito ,  IWAKAMI, Noboru ,  NAKAGAWA, Masaya ,  YAMAGUCHI, Sumie

IPC分类号： C07C217/10 ,  C07D303/36

CPC分类号： C07D235/06 ,  C07C217/10 ,  C07C2602/08 ,  C07D215/14 ,  C07D241/42 ,  C07D277/64 ,  C07D307/79 ,  C07D311/22 ,  C07D317/54 ,  C07D319/18 ,  C07D333/54 ,  C07D333/56 ,  C07D333/62 ,  C07D333/68

摘要： N-Alkoxyalkyl-N,N-dialkylamine derivatives of general formula [1] or salts thereof, which exhibit antihypoxic, nerve protecting and nerve regeneration promoting effects and are useful as remedies for nerve degeneration diseases, wherein R?1 and R2¿ are each hydrogen, halogeno, or the like; R?3 and R4¿ are each optionally substituted alkyl, cycloalkyl, or aralkyl; R?5, R6, R7 and R8¿ are each hydrogen or alkyl; D is a five- or six-membered heterocycle or a hydrocarbon ring; m is 1 to 5; and n is 1 to 6.

摘要翻译： 由下述通式A1U表示的N-烷氧基烷基 - N，N-二烷基胺衍生物： worin环D darstellt的5-或6-元杂环或烃环; [R <3>和R <4>哪些是相同或不同的，在unsubstituiertem或substituiertem烷基，环烷基或芳烷基代表; 和R <1>，R <2>，R <5> - [R <6> - [R <7> - [R <8>，m和n如说明书中所定义，或其盐具有抗缺氧 活性，神经保护活性和神经再生促销婷活性，可用于神经变性疾病的治疗是有用的。

公开(公告)号：EP1514542A1

公开(公告)日：2005-03-16

申请号：EP03760132.5

申请日：2003-04-03

申请人： TOYAMA CHEMICAL CO., LTD.

发明人： NAKADA, Yasushi ,  NAKAGAWA, Masaya ,  ONO, Satoshi

IPC分类号： A61K31/381 ,  A61K31/122 ,  A61K31/21 ,  A61K31/397 ,  A61K31/445 ,  A61K31/473 ,  A61K31/55 ,  A61K45/00 ,  A61P25/28 ,  A61P43/00

CPC分类号： A61K45/06 ,  A61K31/122 ,  A61K31/21 ,  A61K31/381 ,  A61K31/397 ,  A61K31/445 ,  A61K31/473 ,  A61K31/55 ,  A61K2300/00

摘要： An alkyl ether derivative represented by the formula:
wherein R 1 , R 2 , R 3 , R 4 , m and n are as defined in the specification, or salts thereof exhibits synergistically improved anti-hypoxic activity when combined with a compound having an acetylcholine esterase inhibitory activity. Therefore, the combination according to the present invention is useful as a method for improving cerebral function. Further, a pharmaceutical composition containing the compound relating to the combination according to the present invention is useful for treatment and prevention of dysfunction of cerebral acetylcholine neurons in the sequelae of cerebrovascular dementia, senile dementia, Alzheimer's disease and ischemic cerebral lesion and in the cerebral apoplexy or the memory impairment caused by selective neuronal death.

摘要翻译： 由下式表示的烷基醚衍生物：其中R 1，R 2，R 3，R 4，m和n如说明书中所定义，或其盐表现出协同改进的抗 与具有乙酰胆碱酯酶抑制活性的化合物组合时的低氧活性。 因此，本发明的组合作为改善脑功能的方法是有用的。 此外，含有根据本发明的组合的化合物的药物组合物可用于治疗和预防脑血管性痴呆，老年痴呆，老年痴呆症和缺血性脑损伤的后遗症中脑乙酰胆碱神经元的功能障碍和脑中风 或由选择性神经元死亡引起的记忆障碍。