公开(公告)号：EP1234038A1

公开(公告)日：2002-08-28

申请号：EP00978773.0

申请日：2000-11-17

申请人： TRANSKARYOTIC THERAPIES, INC.

发明人： Treco, Douglas A. ,  Concino, Michael F. ,  Duguay, Stephen, J.

IPC分类号： C12N15/16 ,  C12N15/62 ,  C12N5/10 ,  C07K14/605 ,  C07K14/655 ,  C12P21/06

CPC分类号： C12P21/06 ,  A61K38/00 ,  C07K14/605 ,  C07K14/655 ,  C07K2319/00 ,  C07K2319/02

摘要： The present invention features a nucleic acid construct for expressing a product, e.g., a small peptide such as GLP-1. The construct includes a nucleic acid sequence encoding a signal peptide and a nucleic acid sequence which encodes the pro-region of somatostatin or a functional fragment thereof. The construct can further include a sequence encoding the small peptide or the construct can be used to express an endogenous genomic sequence encoding the small peptide. The present invention further features genetically engineered cells, and methods of using such constructs or cells.