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    Process to prepare hard gelatine capsules containing chinese herbal extracts
    2.
    发明公开
    Process to prepare hard gelatine capsules containing chinese herbal extracts 失效
    Verfahren zum Herstellen Hartgelatinekapseln，die chinesischeKräuterextrakteenthalten。

    公开(公告)号：EP0530833A1

    公开(公告)日：1993-03-10

    申请号：EP92115192.4

    申请日：1992-09-04

    申请人： TSUMURA & CO.

    发明人： Uchida, Toshihiro, c/o Tsumura & Co. ,  Konishi, Shin'ichiro, c/o Tsumura & Co. ,  Kimura, Takayoshi, c/o Tsumura & Co.

    IPC分类号： A61K35/78 ,  A61K9/48

    CPC分类号： A61K9/4858 ,  A61K9/1611 ,  A61K9/1652 ,  A61K36/00 ,  A61K36/23 ,  A61K36/258 ,  A61K36/28 ,  A61K36/539 ,  A61K36/718 ,  A61K36/725 ,  A61K36/744 ,  A61K36/756 ,  A61K36/9066 ,  Y10S514/962 ,  Y10S514/974 ,  A61K2300/00

    摘要： When a powdered extract of Kampo medicine is encapsulated as such in hard capsules, the pharmaceutical effects of the Kampo medicine cannot be fully achieved, since the dissolution of the content of the hard capsules requires a long period of time. Therefore, the present invention aims at providing Kampo medicine hard capsules having good dissolution properties.
    The present invention provides a process for producing Kampo medicine hard capsules which comprises compacting Kampo medicine extract powder, mixing magnesium stearate with the compacted Kampo medicine extract powder and filing the mixture into gelatin hard capsules.
    It is preferable that the weight ratio of the magnesium stearate to the Kampo medicine powdered extract ranges from 0.5/100 to 3/100. Furthermore, it is preferable that said Kampo medicine is selected from Oren-gedoku-to, Sho-saiko-to, Ninjin-to, San'o-shashin-to, Mao-bushi-saishin-to, Anchu-san, Keishi-bukuryo-gan, Byakko-ka-ninjin-to, Shakuyaku-kanzo-to and Sairei-to.

    摘要翻译： 当汉方医药的粉末提取物如此包装在硬胶囊中时，由于硬胶囊的内容物的溶解需要较长的时间，所以不能完全实现汉方药物的药效。 因此，本发明的目的在于提供具有良好溶解性能的汉方药用硬胶囊。 本发明提供一种生产汉方药物硬胶囊的方法，其包括压制汉方药物提取物粉末，将硬脂酸镁与压实的汉方药物提取物粉末混合并将混合物填充到明胶硬胶囊中。 优选硬脂酸镁与汉方药粉末提取物的重量比为0.5 / 100〜3/100。 此外，优选的是，所述汉方药物选自Oren-gedoku至Sho-saiko-to，Ninjin-to Sano-shashin-to，Mao-bushi-saishin-to，Anchu-san，Keishi- Buakuryo-gan，Byakko-ka-ninjin-to，Shakuyaku-kanzo-to和Sairei-to。