公开(公告)号：EP3403673A1

公开(公告)日：2018-11-21

申请号：EP17738422.9

申请日：2017-01-11

申请人： National University Corporation Tokyo Medical and Dental University

发明人： NISHIMURA, Emi ,  MATSUMURA, Hiroyuki

IPC分类号： A61K45/00 ,  A61K8/97 ,  A61K31/222 ,  A61K31/506 ,  A61K31/7088 ,  A61K31/713 ,  A61K36/04 ,  A61K36/05 ,  A61K36/14 ,  A61K36/18 ,  A61K36/185 ,  A61K36/23 ,  A61K36/28 ,  A61K36/30 ,  A61K36/424 ,  A61K36/47 ,  A61K36/48 ,  A61K36/488 ,  A61K36/489 ,  A61K36/53

CPC分类号： A61K31/713 ,  A61K8/97 ,  A61K31/05 ,  A61K31/16 ,  A61K31/222 ,  A61K31/355 ,  A61K31/375 ,  A61K31/381 ,  A61K31/506 ,  A61K31/7048 ,  A61K31/7088 ,  A61K36/04 ,  A61K36/05 ,  A61K36/14 ,  A61K36/18 ,  A61K36/185 ,  A61K36/23 ,  A61K36/28 ,  A61K36/30 ,  A61K36/424 ,  A61K36/47 ,  A61K36/48 ,  A61K36/488 ,  A61K36/489 ,  A61K36/53 ,  A61K36/54 ,  A61K36/60 ,  A61K36/718 ,  A61K36/738 ,  A61K36/74 ,  A61K36/82 ,  A61K38/55 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P17/14 ,  A61Q5/00 ,  A61Q7/00 ,  C12Q1/37

摘要： The present invention provides novel compositions for suppressing or improving hair loss, and compositions for suppressing or improving graying. More specifically, it provides agents that stabilize type XVII collagen expression, preferably agents that suppress the degradation of type XVII collagen by ELANE inhibitors and such, and compositions comprising a DNA repair-promoting agent or a DNA damage-suppressing agent as an active ingredient. Advantageous suppressive effects of hair loss and graying can be obtained when a composition comprising as an active ingredient a suppressive agent of type XVII collagen degradation such as an ELANE inhibitor is administered to a mammal. For the ELANE inhibitors, suppressive agents of type XVII collagen degradation and DNA repair-promoting agents, low-molecular compounds, polypeptides, proteins, antibodies, or nucleic acid medicine such as antisense oligos or siRNAs may be used. A method of screening for effective substances for suppression of hair loss and graying is also provided.

公开(公告)号：EP2990047A4

公开(公告)日：2016-12-14

申请号：EP14788600

申请日：2014-02-17

申请人： UNIV-INDUSTRY COOP GROUP OF KYUNG HEE UNIV

发明人： KIM DONG HYUN ,  HAN MYUNG JOO

IPC分类号： A61K36/8964 ,  A23L2/00 ,  A61K31/7048 ,  A61K36/718 ,  A61P1/00

CPC分类号： A61K36/8964 ,  A23L2/02 ,  A23L2/52 ,  A23L7/10 ,  A23L13/428 ,  A23L23/00 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/7048 ,  A61K36/718 ,  A61K2300/00 ,  A23V2200/32

摘要： The present invention relates to a novel use of an Anemarrhena asphodeloides Bunge extract, and the like, and a Rhizoma Coptidis extract, and the like, and specifically, provides a composition for preventing, relieving, or treating colitis, including, as active ingredients: one or more selected from the Anemarrhena asphodeloides Bunge extract, a C3 to C8-alcohol-soluble fraction of the Anemarrhena asphodeloides Bunge extract, mangiferin, a pharmaceutically acceptable salt of mangiferin, neomangiferin, or a pharmaceutically acceptable salt of neomangiferin; and one or more selected from a Rhizoma Coptidis extract and a C3 to C8-alcohol-soluble fraction of the Rhizoma Coptidis extract. The combined extract comprising the Anemarrhena asphodeloides Bunge extract, and the like, and the Rhizoma Coptidis extract, and the like, according to the present invention, have excellent effects of preventing or treating colitis in colitis-induced animal models, and thus can be used as food and pharmaceutical materials constituting a pharmaceutical composition or a functional food composition.

公开(公告)号：EP2731618A4

公开(公告)日：2016-02-10

申请号：EP13752274

申请日：2013-02-21

申请人： SHIMOIDE YOSHITERU

发明人： SHIMOIDE YOSHITERU

IPC分类号： A61K36/00 ,  A61P11/00 ,  A61P17/00 ,  A61P25/24 ,  A61P37/08

CPC分类号： A61K36/756 ,  A61K36/00 ,  A61K36/076 ,  A61K36/232 ,  A61K36/233 ,  A61K36/258 ,  A61K36/284 ,  A61K36/481 ,  A61K36/484 ,  A61K36/539 ,  A61K36/54 ,  A61K36/71 ,  A61K36/718 ,  A61K36/725 ,  A61K36/744 ,  A61K36/752 ,  A61K36/9068 ,  A61K2300/00

公开(公告)号：EP1734975B1

公开(公告)日：2015-06-10

申请号：EP05725522.6

申请日：2005-03-14

申请人： Herbs Spring, LLC

发明人： LI, Xiu-Min ,  SAMPSON, Hugh A.

IPC分类号： A61K36/185 ,  A61K36/232 ,  A61K36/074 ,  A61K36/736 ,  A61K36/258 ,  A61K36/9068 ,  A61K36/54 ,  A61K36/756 ,  A61K36/758 ,  A61K36/718 ,  A61P37/08

CPC分类号： A61K36/718 ,  A61K36/074 ,  A61K36/185 ,  A61K36/232 ,  A61K36/258 ,  A61K36/54 ,  A61K36/736 ,  A61K36/756 ,  A61K36/758 ,  A61K36/9068 ,  A61K45/06 ,  A61K2300/00

公开(公告)号：EP2731618A1

公开(公告)日：2014-05-21

申请号：EP13752274.4

申请日：2013-02-21

申请人： Shimoide, Yoshiteru

发明人： Shimoide, Yoshiteru

IPC分类号： A61K36/00 ,  A61P11/00 ,  A61P17/00 ,  A61P25/24 ,  A61P37/08

CPC分类号： A61K36/756 ,  A61K36/00 ,  A61K36/076 ,  A61K36/232 ,  A61K36/233 ,  A61K36/258 ,  A61K36/284 ,  A61K36/481 ,  A61K36/484 ,  A61K36/539 ,  A61K36/54 ,  A61K36/71 ,  A61K36/718 ,  A61K36/725 ,  A61K36/744 ,  A61K36/752 ,  A61K36/9068 ,  A61K2300/00

摘要： The invention aims to provide a composition for treating atopic dermatitis, bronchial asthma, allergic rhinitis or major depressive disorder (depression), comprising a mixture of Formula antidoti coptidis (orengedokuto) and Formula repletionis animalis et supletionis medii (hochuekkito) or a mixture of Formula antidoti coptidis (orengedokuto) and Formula glycyrrhizae atractylodis cinnamomi hoelen (ryokeijutsukanto) as active components. Provided is a composition for preventing or treating an allergic disease or major depressive disorder, comprising a mixture of Formula antidoti coptidis (orengedokuto) and Formula repletionis animalis et supletionis medii (hochuekkito) or a mixture of Formula antidoti coptidis (orengedokuto) and Formula glycyrrhizae atractylodis cinnamomi hoelen (ryokeijutsukanto) as active components.

公开(公告)号：EP1781107B1

公开(公告)日：2013-08-28

申请号：EP05789229.1

申请日：2005-08-24

申请人： Sun Ten Phytotech Co., Ltd ,  Shen, Chung Guang

发明人： SHEN, Chung Guang ,  CHUANG, Wu-Chang

IPC分类号： A61K36/258 ,  A61K36/708 ,  A61K36/718 ,  A61K36/539 ,  A61P9/12

CPC分类号： A61K36/708 ,  A61K36/258 ,  A61K36/539 ,  A61K36/718 ,  A61K36/9068 ,  A61K2300/00

公开(公告)号：EP2307034A4

公开(公告)日：2012-04-11

申请号：EP09762686

申请日：2009-06-12

申请人： AHN GOOK PHARMACEUTICAL CO LTD

发明人： AUH JIN ,  KIM CHANG-HWAN ,  HAN CHANG-KYUN ,  YEON SUNG-HUM ,  SHIN YOUNG-JUNE ,  SHIN MIN-KI ,  CHANG SOO-IM

IPC分类号： A61K36/718 ,  A61K36/25 ,  A61P11/10 ,  A61P11/14

CPC分类号： A61K36/718 ,  A61K36/25 ,  A61K2300/00

摘要： A composition for suppressing cough, removing sputum, preventing and/or treating a respiratory disease comprising an extract of Coptidis rhizoma or a combined extract of Coptidis rhizoma with ivy leaf as an active ingredient, and a method of suppressing cough, removing sputum, and/or preventing and/or treating respiratory disease using the composition, are provided.

公开(公告)号：EP1781107A4

公开(公告)日：2010-02-17

申请号：EP05789229

申请日：2005-08-24

申请人： SUN TEN PHYTOTECH CO LTD ,  SHEN CHUNG GUANG

发明人： SHEN CHUNG GUANG ,  CHUANG WU-CHANG

IPC分类号： A61K36/539 ,  A61K36/258 ,  A61K36/708 ,  A61K36/718 ,  A61K36/9068 ,  A61P9/12

CPC分类号： A61K36/708 ,  A61K36/258 ,  A61K36/539 ,  A61K36/718 ,  A61K36/9068 ,  A61K2300/00

公开(公告)号：EP1895972A4

公开(公告)日：2009-07-29

申请号：EP06773021

申请日：2006-06-14

申请人： NEW CHAPTER INC ,  UNIV TEXAS

发明人： NEWMARK THOMAS ,  SCHULICK PAUL ,  NEWMAN ROBERT ,  AGGARWAL BHARAT

IPC分类号： A61K36/00

CPC分类号： A61K36/9066 ,  A61K36/29 ,  A61K36/53 ,  A61K36/539 ,  A61K36/704 ,  A61K36/718 ,  A61K36/82 ,  A61K36/9068 ,  A61K2300/00

公开(公告)号：EP1374881A4

公开(公告)日：2004-04-21

申请号：EP01274052

申请日：2001-11-01

申请人： LI HONGFEN

发明人： LI HONGFEN

IPC分类号： A61K33/06 ,  A61K35/64 ,  A61K36/00 ,  A61K36/06 ,  A61K36/17 ,  A61K36/238 ,  A61K36/355 ,  A61K36/481 ,  A61K36/538 ,  A61K36/539 ,  A61K36/634 ,  A61K36/65 ,  A61K36/734 ,  A61K36/736 ,  A61K36/756 ,  A61P11/06 ,  A61K35/78

CPC分类号： A61K36/8966 ,  A61K36/17 ,  A61K36/238 ,  A61K36/28 ,  A61K36/344 ,  A61K36/355 ,  A61K36/481 ,  A61K36/484 ,  A61K36/487 ,  A61K36/535 ,  A61K36/538 ,  A61K36/539 ,  A61K36/56 ,  A61K36/634 ,  A61K36/65 ,  A61K36/718 ,  A61K36/734 ,  A61K36/736 ,  A61K36/756 ,  A61K36/79 ,  A61K36/8998 ,  A61K36/904 ,  A61K2300/00

摘要： The present invention disclosed a pharmaceutical preparation of Chinese herb which consists of Kidney-reinforcing and antiasthma herbs, wherein said Chinese herbs comprises Ferilla Frutescens, Prunus Armeniaca, Glycyrrhiza Uralensis, Scutellaria Baicalensis, Coptis Chinesis, Tusilago Farfara, Stemona Sessilifolia, Fritllaria Cirrhosa, Pheretima Aspergillum, Psoralea Corylifolia, Codonopsis Pilosula, Hordeum Vulgara, Massa Fermentata Medicalis, Schisandra Chinensis, Gypsum. The preparation has been used in China for 20 years, and in Israel for more than 5 years. It has cured thousands of patients suffering from asthma, with the effective rate of 93%. The present pharmaceutical preparation can relieve cough, expel phlegm, resist the airway allergic inflammation reaction, improve the pulmonary function and the partial pressure of the oxygen in blood, increase CD2, CD4, CD4/CD8, reduce IgE in blood, and increase CAMP, reduce CGMP in blood, stabilize clasmatoblasts, inhibit the release of histamine, stop asthmatic attack. As is shown in the electron microscope, the preparation protects pneumonocytes, increase the pneumonocytes of type 2, and recover the vital capacity. It can be applied to hormone depending patients for adjusting the decrease of the cerebral ganglia hypophysis adrenal axes. To further demonstrate the curative effect, a study of clinical observation was carried out in the Tel-Hashomer Hospital in Israel, which proved the effect was quit remarkable.