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1.发明公开NANOEMULSION EYEDROP COMPOSITION CONTAINING CYCLOSPORINE AND METHOD FOR PREPARING SAME 有权NANOMPULSIONS-AUGENTROPFENZUSAMMENSETZUNG MIT CYCLOSPORIN UND VERFAHREN ZUR HERSTELLUNG DAVON
公开(公告)号：EP3000474A1
公开(公告)日：2016-03-30
申请号：EP14801762.7
申请日：2014-05-20
发明人： LEE, Joon Youb , SHIN, Youn Jae , RYU, Sang-Rok
CPC分类号： A61K9/1075 , A61K9/0048 , A61K38/13 , A61K47/08 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/44
摘要： The present invention relates to an ophthalmic nanoemulsion composition and a method for preparing the same which increases the solubility of cyclosporine as an active ingredient and improves the stability of the ophthalmic composition by mixing cyclosporine, a nonaqueous solvent, an emulsifier, and an aqueous solvent, and a method for preventing or treating dry eye syndrome using the same. The ophthalmic nanoemulsion composition according to the present invention is characterized by having an average particle size of 200 nm or less, preferably 100 nm or less, and having a very narrow particle distribution. Therefore, sterilizing filtration is available, stability is improved and has superior effect in clinical enhancement of foreign body sensation and visual disturbance, and thus the ophthalmic nanoemulsion composition of the present disclosure can be effectively used as an ophthalmic composition.
摘要翻译： 本发明涉及眼用纳米乳液组合物及其制备方法，其增加了环孢菌素作为活性成分的溶解性，并通过混合环孢菌素，非水溶剂，乳化剂和水性溶剂来提高眼用组合物的稳定性， 以及使用其来预防或治疗干眼症的方法。 本发明的眼用纳米乳剂组合物的平均粒径为200nm以下，优选为100nm以下，粒径分布非常窄。 因此，可以获得灭菌过滤，稳定性提高，并且在临床增强异物感觉和视觉障碍方面具有优异的效果，因此本公开的眼用纳米乳剂组合物可以有效地用作眼用组合物。
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公开(公告)号：EP3000474B1
公开(公告)日：2018-11-28
申请号：EP14801762.7
申请日：2014-05-20
发明人： LEE, Joon Youb , SHIN, Youn Jae , RYU, Sang-Rok
CPC分类号： A61K9/1075 , A61K9/0048 , A61K38/13 , A61K47/08 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/44
摘要： The present invention relates to an ophthalmic nanoemulsion composition and a method for preparing the same which increases the solubility of cyclosporine as an active ingredient and improves the stability of the ophthalmic composition by mixing cyclosporine, a nonaqueous solvent, an emulsifier, and an aqueous solvent, and a method for preventing or treating dry eye syndrome using the same. The ophthalmic nanoemulsion composition according to the present invention is characterized by having an average particle size of 200 nm or less, preferably 100 nm or less, and having a very narrow particle distribution. Therefore, sterilizing filtration is available, stability is improved and has superior effect in clinical enhancement of foreign body sensation and visual disturbance, and thus the ophthalmic nanoemulsion composition of the present disclosure can be effectively used as an ophthalmic composition.
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