公开(公告)号：EP3718545A1

公开(公告)日：2020-10-07

申请号：EP18883950.0

申请日：2018-11-28

申请人： Taiho Pharmaceutical Co., Ltd.

发明人： UENO, Hiroyuki ,  HOSHINO, Takuya

IPC分类号： A61K31/4245 ,  A61K45/00 ,  A61P35/00 ,  A61P43/00 ,  C07D249/04

摘要： The present invention provides a method of enhancing an antitumor effect by a compound strongly inhibiting ribonucleotide reductase (RNR) or a salt thereof.
A combination formulation involving combined administration of a sulfonamide compound represented by Formula (I) [In the formula, X 1 represents an oxygen atom or the like; X 2 represents an oxygen atom; X 3 represents -NH-; X 4 represents a hydrogen atom or the like; R 1 represents -C(R 11 ) (R 12 )- or the like; R 11 and R 12 are the same or different and each represents a hydrogen atom or the like; R 2 represents an optionally substituted C6-C14 aromatic hydrocarbon group or the like; R 3 represents an optionally substituted C6-C14 aromatic hydrocarbon group or the like; R 4 represents a hydrogen atom or the like] or a salt thereof, having RNR inhibitory activity, and other antitumor agent(s).

公开(公告)号：EP3466934A1

公开(公告)日：2019-04-10

申请号：EP17806708.8

申请日：2017-05-30

申请人： Taiho Pharmaceutical Co., Ltd.

发明人： MIYAHARA, Seiji ,  UENO, Hiroyuki ,  HARA, Shoki ,  OGINO, Yoshio

IPC分类号： C07D249/04 ,  A61K31/4245 ,  A61K31/428

摘要： The present invention provides a novel sulfonamide compound having a ribonucleotide reductase inhibitory activity or a salt thereof, and a pharmaceutical composition containing the same as an active ingredient.
A compound represented by Formula (I) [wherein, X 1 represents an oxygen atom or the like; X 2 represents an oxygen atom; X 3 represents -NH-; X 4 represents a hydrogen atom or the like; R 1 represents -C(R 11 )(R 12 )- or the like; R 11 and R 12 are the same or different and each represents a hydrogen atom or the like; R 2 represents an optionally substituted C 6 -C 14 aromatic hydrocarbon group or the like; R 3 represents an optionally substituted C 6 -C 14 aromatic hydrocarbon group or the like; R 4 represents a hydrogen atom or the like] or a salt thereof.