公开(公告)号：EP0354538A3

公开(公告)日：1991-11-06

申请号：EP89114663.1

申请日：1989-08-08

申请人： Takeda Chemical Industries, Ltd.

发明人： Naito, Kenzo ,  Ishibashi, Yukio ,  Fujitani, Toshihiko

IPC分类号： C07D501/24 ,  C07D501/18

CPC分类号： C07D501/04 ,  C07D501/18 ,  C07D501/26

摘要： A method for producing 3-(3-oxobutyryloxymethyl)-3-­cephem-4-carboxylic acids which are antibiotics or intermediates for the synthesis of antibiotics, at a low temperature in a very short period of time and besides in good yield, characterized by reacting a 3-hydroxylmethyl-­3-cephem-4-carboxylic acid with diketene in the presence of a 4-(tertiary-amino)pyridine and if necessary, when a 7-acylamino-3-(3-oxobutyryloxymethyl)-3-cephem-4-carboxyl­ic acid is obtained, subjecting it to deacylation at the 7-position thereof.

公开(公告)号：EP0354538A2

公开(公告)日：1990-02-14

申请号：EP89114663.1

申请日：1989-08-08

申请人： Takeda Chemical Industries, Ltd.

发明人： Naito, Kenzo ,  Ishibashi, Yukio ,  Fujitani, Toshihiko

IPC分类号： C07D501/24 ,  C07D501/18

CPC分类号： C07D501/04 ,  C07D501/18 ,  C07D501/26

摘要： A method for producing 3-(3-oxobutyryloxymethyl)-3-­cephem-4-carboxylic acids which are antibiotics or intermediates for the synthesis of antibiotics, at a low temperature in a very short period of time and besides in good yield, characterized by reacting a 3-hydroxylmethyl-­3-cephem-4-carboxylic acid with diketene in the presence of a 4-(tertiary-amino)pyridine and if necessary, when a 7-acylamino-3-(3-oxobutyryloxymethyl)-3-cephem-4-carboxyl­ic acid is obtained, subjecting it to deacylation at the 7-position thereof.

摘要翻译： 一种生产3-（3-氧代丁酰氧基甲基）-3-头孢烯-4-羧酸的方法，它是抗生素或用于合成抗生素的中间体，在非常短的时间内在低温下，以及良好的产率，其特征在于 在4-（叔 - 氨基）吡啶的存在下，使3-羟基甲基-3-头孢烯-4-羧酸与双烯酮反应，如果需要，当7-酰基氨基-3-（3-氧代丁酰氧基甲基）-3-头孢烯 -4-羧酸，使其在其7-位脱羟基。