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10 条记录 (耗时 0.015 秒)

    Novel 2-substituted coumaran derivatives
    1.
    发明公开
    Novel 2-substituted coumaran derivatives 失效
    新的2-取代的香豆素衍生物

    公开(公告)号：EP0345592A1

    公开(公告)日：1989-12-13

    申请号：EP89109676.0

    申请日：1989-05-30

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Goto, Giichi ,  Ohkawa, Shigenori ,  Fukuda, Naohisa

    IPC分类号： C07D307/79 ,  C07D307/92 ,  C07D405/12

    CPC分类号： C07D307/79 ,  C07D307/80 ,  C07D307/81

    摘要： The present invention relates to a compound of the formula:
    wherein R¹ stands for hydrogen or a lower alkyl; n denotes an integer of 1 to 6; X stands for an optionally oxidized sulphur atom, oxygen atom or an optionally substituted imino; R² stands for methyl or an organic residual group bonded through methylene, methine a quaternary carbon; R³ stands for a lower alkyl; R⁴ stands for hydrogen or acyl; R⁵ and R⁶ each stand for a lower alkoxy or a lower alkyl, or R⁵ and R⁶ combinedly stand for butadienylene, and salts thereof.
    The compound (I) of the present invention has a strong 5-lipoxygenase inhibiting action, is of high safety and is useful as, among others, an agent for ameliorating circulatory system, an anti-allergic agent and a pharmaceutical agent for central nervous system.

    摘要翻译： 本发明涉及下式化合物：其中R 1代表氢或低级烷基; n表示1至6的整数; X代表任选氧化的硫原子，氧原子或任选取代的亚氨基; R 2代表甲基或通过亚甲基结合的有机残基，次甲基为季碳; R 3代表低级烷基; R 4代表氢或酰基; R 5和R 6分别代表低级烷氧基或低级烷基，或者R 5和R 6共同代表丁二烯基及其盐。 本发明的化合物（I）具有强的5-脂氧合酶抑制作用，安全性高，作为循环系统改善剂，抗过敏剂，中枢神经系统药剂等 。

    Optically active isoindoline derivatives, their production and use
    5.
    发明公开
    Optically active isoindoline derivatives, their production and use 失效
    Optisch aktive Isoindolin-Derivate，ihre Herstellung und Anwendung。

    公开(公告)号：EP0529778A1

    公开(公告)日：1993-03-03

    申请号：EP92306040.4

    申请日：1992-06-30

    申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.

    发明人： Goto, Giichi ,  Fukuda, Naohisa

    IPC分类号： C07D471/04 ,  C07D519/00 ,  A61K31/445

    CPC分类号： C07D471/04

    摘要： The present invention provides an optically active isoindoline derivative represented by the formula:

    , which is useful as an improving, therapeutic and preventive agent for anxiety-associated nervous symptoms, and an intermediate for synthesis thereof.

    摘要翻译： 本发明提供由下式表示的光学活性异二氢吲哚衍生物：其可用作焦虑相关神经症状的改善，治疗和预防剂及其合成中间体。

    Crystal forms of optically active isoindolines and their use
    8.
    发明公开
    Crystal forms of optically active isoindolines and their use 失效
    Kristallformen von optisch aktiven Isoindolinen und ihre Anwendung。

    公开(公告)号：EP0602814A1

    公开(公告)日：1994-06-22

    申请号：EP93309487.2

    申请日：1993-11-29

    申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.

    发明人： Goto, Giichi ,  Fukuda, Naohisa

    IPC分类号： C07D519/00 ,  A61K31/445

    CPC分类号： C07D519/00 ,  A61K31/445

    摘要： A crystal form of the optically active isoindoline derivative represented by the formula:

    is useful as an improving, therapeutic and preventive agent for anxiety-associated nervous symptoms, and an intermediate for synthesis thereof.

    摘要翻译： 由下式表示的光学活性异二氢吲哚衍生物的结晶形式：可用作焦虑相关神经症状的改善，治疗和预防剂及其合成中间体。

    2-substituted coumaran derivatives
    10.
    发明公开
    2-substituted coumaran derivatives 失效
    在2-Stellung Substierte Cumaranderivate。

    公开(公告)号：EP0345593A1

    公开(公告)日：1989-12-13

    申请号：EP89109679.4

    申请日：1989-05-30

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Goto, Giichi ,  Ohkawa, Shigenori ,  Fukuda, Naohisa

    IPC分类号： C07D307/79 ,  C07D307/92 ,  A61K31/34

    CPC分类号： C07D307/79 ,  C07D307/80

    摘要： The present invention relates to a compound of the formula:
    wherein R 1 is hydrogen or a lower alkyl; R 2 is methyl which is substituted by a carboxy, alkoxycarbonyl, cyano, halogen, aryl or heterocyclic group or C 2 - 15 chain-like hydrocarbon residue having no lower alkyl at the a-position which may be substituted by a carboxy, alkoxycarbonyl, cyano, halogen, aryl or heterocyclic group; R 3 is a lower alkyl; R 4 is hydrogen or acyl; and R 5 and R 6 each is a lower alkyl or lower alkoxy, or R 5 and R 6 combinedly are butadienylene or a salt thereof.
    The compound (I) of the present invention has a strong 5- and 12-lipoxygenase inhibiting action, is of high safety and is useful as, among others, an agent for ameliorating circulatory system, an anti-allergic agent and a pharmaceutical agent for central nervous system

    摘要翻译： 本发明涉及下式的化合物：其中R 1是氢或低级烷基; R 2是被羧基，烷氧基羰基，氰基，卤素，芳基或杂环基取代的甲基或在可以被羧基取代的α-位上没有低级烷基的C 2--15链状烃残基，烷氧基羰基 ，氰基，卤素，芳基或杂环基; R 3是低级烷基; R 4是氢或酰基; R 5和R 6各自为低级烷基或低级烷氧基，或者R 5和R 6组合为丁二烯基或其盐。 本发明的化合物（I）具有强的5-和12-脂氧合酶抑制作用，其安全性高，可用作改善循环系统的药剂，抗过敏剂和药剂 中枢神经系统