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35 条记录 (耗时 0.014 秒)

    Aminoketone compounds
    2.
    发明公开
    Aminoketone compounds 失效
    Aminoketonverbindungen。

    公开(公告)号：EP0401715A2

    公开(公告)日：1990-12-12

    申请号：EP90110515.5

    申请日：1990-06-02

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Goto, Giichi ,  Nagaoka, Akinobu ,  Ishihara, Yuji

    IPC分类号： C07C225/06 ,  C07C221/00 ,  C07D295/112 ,  A61K31/135 ,  A61K31/40

    CPC分类号： C07D295/108 ,  A61K31/135 ,  A61K31/40 ,  C07C225/16

    摘要： An aminoketone compound of the formula

    wherein ring A′ means a five through eight-membered cyclic group which may be substituted and may contain one or two hetero atom(s) of O, S, N, as the ring-constituents; R¹′ means a hydrogen atom or a hydrocarbon residue which may be substituted; R²′ means a hydrogen atom or a lower alkyl group; R³′ means an aromatic group which may be substituted; R⁴′ means a hydrogen atom, a lower alkyl group or aromatic group which may be substituted; n′ means an integer of 2 to 7, or a salt thereof, is useful as an cholinesterase inhibitors and a cerebral function ameliorating agent.

    摘要翻译： 式（CHEM）的氨基酮化合物，其中环A min表示可以被取代的五至八元环基，并且可以含有一个或两个O，S，N的杂原子作为环组分; R min表示氢原子或可被取代的烃残基; R 2min表示氢原子或低级烷基; R 3分钟表示可被取代的芳基; R 4分钟表示氢原子，可以被取代的低级烷基或芳基; n min表示2〜7的整数，或其盐可用作胆碱酯酶抑制剂和脑功能改善剂。

    Peptide derivatives, their production and use
    3.
    发明公开
    Peptide derivatives, their production and use 失效
    肽衍生物，其生产和使用

    公开(公告)号：EP0227410A3

    公开(公告)日：1989-02-08

    申请号：EP86309800.0

    申请日：1986-12-16

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Goto, Giichi ,  Nagaoka, Akinobu ,  Wakimasu, Mitsuhiro

    IPC分类号： C07K7/06 ,  A61K37/02 ,  C07K7/16

    CPC分类号： C07K7/16 ,  A61K38/00 ,  Y02P20/55 ,  Y10S930/26

    摘要： A peptide derivative of the general formula
    wherein
    R 1 is a hydrogen atom, a C 1-18 alkyl group or a substituted or unsubstituted phenyl C 1-3 alkyl group; A is an amino or N-C 1-6 alkylamino acid residue; B is a hydroxyl group, a substituted or unsubstituted amino group, or an amino acid or an amide thereof, or a physiologically acceptable salt thereof, can be advantageously used for the treatment and/or prevention of a disease including, among others, senile dementia (Alzheimer's dementia), cerebrovascular dementia, Alzheimer's disease, Pick's disease, Huntington's chorea, Creutzfeldt-Jakob disease, Parkinson's disease, and dementia due to spinocerebellar degeneration.

    Azaspiro compounds, their production and use
    4.
    发明公开
    Azaspiro compounds, their production and use 失效
    Azaspiroverbindungen，ihre Herstellung und Verwendung。

    公开(公告)号：EP0273659A1

    公开(公告)日：1988-07-06

    申请号：EP87311198.3

    申请日：1987-12-18

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Goto, Giichi ,  Nagaoka, Akinobu

    IPC分类号： C07D471/10 ,  A61K31/445

    CPC分类号： C07D471/10

    摘要： Azaspiro compounds of the formula:
    wherein R₁ and R₂ independently represent hydrgen, a hydrocarbon residue which may have a substituent, or an acyl group which may have a substituent; R₃ represents hydrogen or a hydrocarbon residue which may have a substituent; each of X₁ and X₂ is oxygen or sulfur; Y represents oxygen, sulfur or a group of the formula: -N(R₄)-, wherein R₄ represents hydrogen or a lower alkyl group; m represents 0 or 1; n represents 0 or 1, and its salt are novel compounds, possess excellent brain functionimproving action, and are of use as drugs for the prevention and therapy of senile dementia of Alzheimer type, vascular-type dementia and dementia derived from Alzheimer's disease, Pick's disease, Huntington's disease, Creutzfeldt-­Jakob's disease, Parkinson's disease and spinocerebellar degeneration.

    摘要翻译： 其中R 1和R 2独立地表示氢原子，可以具有取代基的烃残基或可具有取代基的酰基; R 3表示氢或可以具有取代基的烃残基; X1和X2各自为氧或硫; Y表示氧，硫或下式基团-N（R 4） - ，其中R 4表示氢或低级烷基; m表示0或1; n表示0或1，其盐为新化合物，具有优异的脑功能改善作用，可用作预防和治疗老年痴呆型老年痴呆，血管型痴呆和源自阿尔茨海默病的痴呆，皮克病 ，亨廷顿病，克雅氏病，帕金森病和脊髓小脑变性。

    Pyrazolo [3,4-d] pyrimidine derivatives, their production and use
    8.
    发明公开
    Pyrazolo [3,4-d] pyrimidine derivatives, their production and use 失效
    吡唑并[3,4-d]嘧啶并吡啶酮，还有Herstellung und Verwendung

    公开(公告)号：EP0237289A2

    公开(公告)日：1987-09-16

    申请号：EP87301950.9

    申请日：1987-03-06

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Naka, Takehiko ,  Nagaoka, Akinobu ,  Furukawa, Yoshiyasu

    IPC分类号： C07D487/04 ,  A61K31/505

    CPC分类号： C07D487/04

    摘要： Novel pyrazola[3,4-d]pyrimidine derivatives represented by the formula (I)
    wherein

    Rls an aryl or heteroaryl group which may be substituted;
    Ris a lower alkyl group;
    R 3 and R 4 are independently hydrogen or a lower alkyl group;
    R 5 is hydrogen, a lower alkyl group or a lower acyl group, the group R 5 being attached at the 1- or 2- position of the pyrazole ring;
    Xis a lower alkylene group which may contain a hetero-atom;

    and the dotted line designates the presence of two double bonds in the pyrazole ring and their salts activate cerebral functions and metabolisms.

    摘要翻译： 由通式（I）表示的新颖的吡唑并[3,4-d]嘧啶衍生物其中R 1是可以被一至三个选自以下的成员所取代的芳基或杂芳基：卤素，C 1-4烷基 C 1-4烷氧基，硝基，氨基，N-C 1-4烷基氨基，N，N-二C 1-4烷基氨基，羟基，三氟甲基，氨基甲酰基，N-C 1-4烷基氨基甲酰基和N，N-二C 1-4烷基氨基甲酰基; R2是C1-4烷基; R3和R4独立地是氢或C1-4烷基; R5是氢，C1-2烷基，C1-5烷酰基或C1-4烷氧基羰基，R5基团连接在吡唑环的1位或2位; X是C 1-7亚烷基或下式的基团： - （CH 2）m Y-（CH 2）n - ，其中m是2或3，n是0-3的整数，Y是氧，硫，亚氨基或N- C1-4alkylimino; 并且虚线表示吡唑环中存在两个双键，并且它们的盐激活脑功能和代谢。

    Dihydropyridine derivatives, their production and use
    9.
    发明公开
    Dihydropyridine derivatives, their production and use 失效
    二氢吡啶衍生物，其生产和使用

    公开(公告)号：EP0138505A3

    公开(公告)日：1986-06-18

    申请号：EP84306719

    申请日：1984-10-02

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Meguro, Kanji ,  Nagaoka, Akinobu

    IPC分类号： C07D211/90 ,  C07D401/12 ,  A61K31/44

    CPC分类号： C07D295/088 ,  C07D211/14 ,  C07D211/90

    摘要： Dihydropyridine derivatives and acid addition salts thereof which are of use as prophylactic or/and therapeutic drugs for cardiovascular diseases, said dihydropyridine derivatives having the formula
    wherein
    R 1 is a hydrogen atom or an aryl, R 2 and R 3 are the same or different and each is an aryl, R 4 and R 6 are the same of different and each is a lower alkyl, R 5 is amino or a lower alkyl, A is an alkylene, X is N or CH and m and n are the same or different and each is 0 or 1, with the proviso that when X is N, R 5 is amino.

    Dihydropyridine derivatives, their production and use
    10.
    发明公开
    Dihydropyridine derivatives, their production and use 失效
    二氢吡啶衍生物，其制备方法和用途。

    公开(公告)号：EP0138505A2

    公开(公告)日：1985-04-24

    申请号：EP84306719.0

    申请日：1984-10-02

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Meguro, Kanji ,  Nagaoka, Akinobu

    IPC分类号： C07D211/90 ,  C07D401/12 ,  A61K31/44

    CPC分类号： C07D295/088 ,  C07D211/14 ,  C07D211/90

    摘要： Dihydropyridine derivatives and acid addition salts thereof which are of use as prophylactic or/and therapeutic drugs for cardiovascular diseases, said dihydropyridine derivatives having the formula
    wherein

    R 1 is a hydrogen atom or an aryl,
    R 2 and R 3 are the same or different and each is an aryl,
    R 4 and R 6 are the same of different and each is a lower alkyl,
    R 5 is amino or a lower alkyl,
    A is an alkylene,
    X is N or CH and
    m and n are the same or different
    and each is 0 or 1,
    with the proviso that when X is N, R 5 is amino.