公开(公告)号：EP1211239A1

公开(公告)日：2002-06-05

申请号：EP00956925.2

申请日：2000-09-05

申请人： Takeda Chemical Industries, Ltd.

发明人： IKEMOTO, Tomomi ,  ITO, Tatsuya, 117.1-7 Asahigaoka-Kukakuseirichinai ,  NISHIGUCHI, Atsuko ,  TOMIMATSU, Kiminori

IPC分类号： C07C229/18 ,  C07C227/14 ,  C07D223/16

CPC分类号： C07D223/16 ,  C07C229/18

摘要： As a process for preparing 2,3-dihydroazepine compounds at low cost in a simple and easy manner, there is provided a process for the preparation of compounds of the formula:
or salts thereof, characterized in that compounds of the formula:
or salts thereof are reacted with compounds of the formula:
or salts thereof to give compounds of the formula:
or salts thereof, which are then subjected to esterification and ring-closing reaction.

摘要翻译： 作为以简单和容易的方式低成本制备2,3-二氢氮杂化合物的方法，提供了制备下式化合物或其盐的方法，其特征在于下式化合物： 或其盐与下式化合物或其盐反应得到下式的化合物或其盐，然后进行酯化和闭环反应。

公开(公告)号：EP1266881A1

公开(公告)日：2002-12-18

申请号：EP01904559.0

申请日：2001-02-20

申请人： Takeda Chemical Industries, Ltd.

发明人： IKEMOTO, Tomomi ,  ITO, Tatsuya, 117.1-7 Asahigaoka-Kukakuseirichinai ,  TOMIMATSU, Kiminori

IPC分类号： C07B37/10 ,  C07D225/06 ,  C07D313/08 ,  C07D313/20

CPC分类号： C07D225/06 ,  C07D313/08 ,  C07D313/20

摘要： A process suitable for safely mass-producing, through a short step, cyclic compounds useful in medicines, agricultural chemicals, foods, cosmetics, and chemical products or as intermediates therefor. The process, which is for producing a compound represented by the formula:
{wherein Z represents an electron-attracting group; W represents optionally substituted ethylene or optionally substituted vinylene; R 3 represents hydrogen or an optionally substituted hydrocarbon group; and X represents a divalent group [provided that when W represents optionally substituted vinylene, then -X-CH 2 -Z is not -X 1 -X 2 -CH 2 -Z (wherein X 1 represents sulfur or optionally substituted nitrogen and X 2 represents optionally substituted ethylene)]} or a salt thereof, is characterized by subjecting a compound represented by the formula (II) or a salt thereof:
(wherein the symbols have the same meanings as the above) to a ring closure reaction in a solvent containing a carbonic diester.

摘要翻译： 一种适用于通过短步安全批量生产用于药物，农药，食品，化妆品和化学产品的环状化合物或其中间体的方法。 该方法用于制备由下式表示的化合物：其中Z表示吸电子基团; W表示任选取代的乙烯或任选取代的亚乙烯基; R 3表示氢或任选取代的烃基; 并且X表示二价基团，当W表示任选取代的亚乙烯基时，则-X-CH 2 -Z不是-X 1 -X 2 -CH 2 -Z（其中X 1表示硫或任选取代的氮 X 2表示任选取代的乙烯）或其盐，其特征在于将由式（II）表示的化合物或其盐：（其中符号具有与上述相同的含义） 在含有碳酸二酯的溶剂中进行闭环反应。