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59 条记录 (耗时 0.027 秒)

    Antiallergic, antiinflammatory and anti-PAF pyridazine compounds
    2.
    发明公开
    Antiallergic, antiinflammatory and anti-PAF pyridazine compounds 失效
    抗疟原虫，抗idaz idaz e e e e e。。。。。。。。。。。。。

    公开(公告)号：EP0548923A2

    公开(公告)日：1993-06-30

    申请号：EP92121818.6

    申请日：1992-12-22

    申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.

    发明人： Miyake, Akio ,  Kawano, Yasuhiko ,  Ashida, Yasuko

    IPC分类号： C07D487/04 ,  C07D487/14 ,  C07D471/14 ,  C07D491/147 ,  A61K31/50

    CPC分类号： C07D487/04

    摘要： [Constitution] A compound represented by the formula [I],
    [Chemical Formula 1]


    [wherein X stands for a methine group or a nitrogen atom; R¹ stands for a hydrogen atom, an optionally substituted lower alkyl group or a halogen atom; R² and R³ respectively stand for a hydrogen atom or an optionally substituted lower alkyl group, or, taken together, may form a 5- to 7-membered ring combined with the adjacent -C=C-; R⁴ and R⁵ respectively stands for a hydrogen atom or an optionally substituted lower alkyl group or, taken together, form a 3- to 7-membered homo- or hetero-cyclic ring combined with the adjacent carbon atom; A stands for an optionally substituted amino group; m and n denote 1 to 4, respectively], salts thereof, a method of preparing same or pharmaceutical compositions containing same.
    [Effects] Excellent antiasthmatic agents

    摘要翻译： 由下式表示的新化合物：其中X代表次甲基（即基团-CH =）或氮原子; R 1表示氢原子，任选取代的低级烷基或卤素原子; R 2和R 3分别表示氢原子或任选取代的低级烷基，或者一起可以形成与相邻的-C = C-结合的5-至7-元环; R 4和R 5分别表示氢原子或任选取代的低级烷基，或者一起形成与相邻碳原子结合的3-至7-元同 - 或杂 - 环; A代表任选取代的氨基; m和n分别表示1至4个或其盐，其具有抗过敏，抗炎和抗PAF活性，并且可用作抗哮喘药。

    Cephem compounds
    5.
    发明公开
    Cephem compounds 失效
    头孢Verbindungen。

    公开(公告)号：EP0228061A2

    公开(公告)日：1987-07-08

    申请号：EP86117844.0

    申请日：1986-12-20

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Nishimura, Tatsuo ,  Yoshimura, Yoshinobu ,  Hashimoto, Naoto ,  Miyake, Akio

    IPC分类号： C07D501/36 ,  A61K31/545

    CPC分类号： C07D501/36

    摘要： A cephem compound of the general formula:
    , wherein R, is an amino group which may be protected, Q is nitrogen or a group of C-R 2 in which R2 is hydrogen or a halogen,

    R 3 is hydrogen or a hydrocarbon residue which may be substituted,
    A is a triazolopyridinyl, triazolopyridazinyl or triazolopyrazinyl group which may be substituted, or a salt or ester thereof
    , and a process for preparing the same and a pharmaceutical composition thereof are disclosed.

    摘要翻译： 通式为：CHEM的头孢烯化合物，其中R 1为可被保护的氨基，Q为氮或R 2为氢或卤素，R 3为氢或烃残基的C-R 2基团 可以被取代，A是可以被取代的三唑并吡啶基，三氮代哒嗪基或三唑并吡嗪基，或其盐或酯，及其制备方法及其药物组合物。

    Bicyclic compounds, their production and use
    8.
    发明公开
    Bicyclic compounds, their production and use 失效
    自行车Verbindungen，我的Herstellung和Verwendung。

    公开(公告)号：EP0035868A1

    公开(公告)日：1981-09-16

    申请号：EP81300901.6

    申请日：1981-03-04

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Oka, Yoshikazu ,  Nishikawa, Kohei ,  Miyake, Akio

    IPC分类号： C07C153/05 ,  C07C149/23 ,  C07D311/68 ,  C07D215/42 ,  C07D209/40 ,  C07D317/70 ,  C07D339/04 ,  A61K31/195 ,  A61K31/35 ,  A61K31/47

    CPC分类号： C07D215/42 ,  C07D311/68 ,  C07D317/70 ,  C07D339/04

    摘要： New bicyclic compounds, inclusive of salts thereof, of the formula:
    wherein R 1 and R 2 , which may be the same or different, each represent hydrogen, halogen, lower alkyl, hydroxyl, lower alkyloxy or aralkyloxy, or R' and R 2 jointly represent lower alkylenedioxy: R 3 and R 4 each represent hydrogen or lower alkyl; R 3 represents hydrogen,lower alkyl or -CH 2 SR 7 (R 7 represents hydrogen or acyl): R 6 represents hydrogen or acyl, or R 6 and R 7 jointly represent a single bond; X represents -CH 2 -, -O- orN-R 5 (R 8 represents hydrogen, acyl or lower alkyl); I and n represents 2, 3 or 4, have inhibitory activities of angiotensin converting enzyme and bradykinin decomposing enzyme, and are useful as antihypertensive agents.

    摘要翻译： 其中R 1和R 2可以相同或不同的新的双环化合物，包括其盐，其具有下式：其中R 1和R 2各自表示氢，卤素，低级烷基，羟基，低级烷氧基或芳烷氧基 ，或R 1和R 2共同表示低级亚烷基二氧基; R 3和R 4各自代表氢或低级烷基; R 5表示氢，低级烷基或-CH 2 SR 7（R 7表示氢或酰基）; R 6表示氢或酰基，或R 6和R 7共同表示单键; X表示-CH 2 - ， - O-或者N-R 8（R 8表示氢，酰基或低级烷基）。 n代表2,3或4，具有血管紧张素转换酶和缓激肽分解酶的抑制活性，可用作抗高血压药。

    Eosinophil chemotaxis inhibitor
    9.
    发明公开
    Eosinophil chemotaxis inhibitor 失效
    嗜酸性粒细胞颗粒的趋化性的抑制剂。

    公开(公告)号：EP0648491A3

    公开(公告)日：1995-07-19

    申请号：EP94114661.5

    申请日：1994-09-17

    申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.

    发明人： Miyake, Akio ,  Ashida, Yasuko ,  Matsumoto, Tatsumi

    IPC分类号： A61K31/50

    CPC分类号： A61K31/5025 ,  A61K31/50

    摘要： A composition for inhibiting an eosinophil chemotaxis which comprises a compound of the formula:

    wherein R¹ represents a hydrogen atom, an optionally substituted lower alkyl group or a halogen atom;
    either A or B represents a nitrogen atom with the other representing a methine group, or both of them represents a methine group;
    R² and R³ independently represent a hydrogen atom or an optionally substituted lower alkyl group, or R² and R³ taken together with the adjacent -C=C-, may form a 5- to 7-membered ring;
    X represents a methylene group, an oxygen atom or S(O)p wherein p represents an integer of 0 to 2;
    Y represents (i) a group of the formula

    wherein R⁴ and R⁵ independently represent a hydrogen atom or an optionally substituted lower alkyl group or (ii) a divalent group derived from an optinally
    substituted 3- to 7-membered homocyclic or heterocyclic ring;
    R⁶ represents a primary to tertiary amino group; m and n independently represent an integer of 0 to 4, or a salt thereof. Said composition is useful for treating a disease related to eosinophil chemotaxis such as allergic rhinits and/or atopic dermatitis and so on.

    Triazolopyridazine derivatives, their production and use
    10.
    发明公开
    Triazolopyridazine derivatives, their production and use 失效
    Triazolopyridazin-Derivate，ihre Herstellung und Verwendung。

    公开(公告)号：EP0620224A1

    公开(公告)日：1994-10-19

    申请号：EP94105542.8

    申请日：1994-04-11

    申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.

    发明人： Miyake, Akio ,  Kajino, Masahiro ,  Ashida, Yasuko

    IPC分类号： C07D487/04 ,  A61K31/50

    CPC分类号： C07D487/04

    摘要： A compound of the formula:

    wherein R¹ is a hydrogen atom, a lower alkyl group or a halogen atom; R² and R³ are a hydrogen atom, a lower alkyl group or a 5- to 7-membered cyclic group formed together with the adjacent -C=C-; X is an oxygen atom, a sulfur atom or a methylene group; Y is an optionally substituted methylene group, a divalent 3- to 7-membered homo- or heterocyclic group; R⁶ and R⁷ are a hydrogen atom, a lower alkyl group, a cycloalkyl group, an aryl group, or a nitrogen-containing heterocyclic group formed together with the adjacent nitrogen atom; m is an integer of 0 to 4; and n is an integer of 0 to 4, or a salt thereof. Said compound has an excellent anti-PAF activity, antiallergic action, etc., thus is useful as an antiasthmatic agent.

    摘要翻译： 下式的化合物：其中R 1是氢原子，低级烷基或卤素原子; R 2和R 3是与相邻的-C≡C-一起形成的氢原子，低级烷基或5-至7-元环基; X是氧原子，硫原子或亚甲基; Y是任选取代的亚甲基，二价3-至7-元均基或杂环基; R 6和R 7是与相邻氮原子一起形成的氢原子，低级烷基，环烷基，芳基或含氮杂环基; m为0〜4的整数。 n为0〜4的整数，或其盐。 所述化合物具有优异的抗PAF活性，抗过敏作用等，因此可用作抗哮喘药。