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公开(公告)号：EP1695961A1
公开(公告)日：2006-08-30
申请号：EP04807076.7
申请日：2004-12-15
IPC分类号： C07D211/58 , C07D211/76 , C07D277/42 , C07D471/04 , C07D487/04 , C07D213/74 , C07D417/04 , C07D401/04 , C07D413/04 , C07D417/06 , C07D417/12 , A61K31/4545 , A61K31/454 , A61K31/5377 , A61K31/496 , A61K31/427 , A61P7/02 , A61P9/10
CPC分类号： A61K31/454 , A61K31/427 , A61K31/4545 , A61K31/496 , A61K31/5377 , C07D417/06
摘要： The present invention provides a urea derivative or a salt thereof, which is useful as a therapeutic agent for thrombosis. The derivative is represented by Formula (I):
[Chemical formula I]
wherein Cy is an aromatic hydrocarbon group which may be substituted or an aromatic heterocyclic group which may be substituted; R 1 is a hydrogen atom or a hydrocarbon group which may be substituted; V is -C(O)-, -S(O)-, or -S(O) 2 -; W is -N(R 2 )-, -O-, or a bond (wherein R 2 is a hydrogen atom or a hydrocarbon group which may be substituted); X is alkylene which may be substituted; Y is -C(O)-, -S(O)-, or -S(O) 2 -; Z is a bond, a chain hydrocarbon group which may be substituted, or -N=; ring A is a non-aromatic nitrogen-containing heterocyclic ring which may be substituted; ring B is a nitrogen-containing heterocyclic ring which may be substituted; and
[Chemical formula 2]
- - - - - - ‾ , - - - - - - ̲
are each independently a single bond or a double bond; provided that R 1 may be bonded to R 2 to form a non-aromatic nitrogen-containing heterocyclic ring and that R 2 may be bonded to a substituent of X to form a non-aromatic nitrogen-containing heterocyclic ring which may be substituted.摘要翻译： 本发明提供可用作血栓症治疗剂的尿素衍生物或其盐。 该衍生物由式（I）表示：[化学式I]其中Cy是可被取代的芳族烃基或可被取代的芳族杂环基; R1是氢原子或可被取代的烃基; V是-C（O） - ， - S（O） - 或-S（O）2 - ; W是-N（R2） - ， - O-或键（其中R2是氢原子或可被取代的烃基）。 X是可被取代的亚烷基; Y是-C（O） - ， - S（O） - 或-S（O）2 - ; Z是键，可被取代的链烃基或-N = 环A是可以被取代的非芳族含氮杂环; 环B是可以被取代的含氮杂环; 和[化学式2] --------，------各自独立地是单键或双键; 条件是R1可以与R2键合形成非芳族含氮杂环并且R2可以与X的取代基键合形成可以被取代的非芳族含氮杂环。
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