公开(公告)号：EP1669352A1

公开(公告)日：2006-06-14

申请号：EP04773616.0

申请日：2004-09-29

申请人： Takeda Pharmaceutical Company Limited

发明人： KUBO, Keiji Takeda Pharmaceutical Company Limited ,  KUROITA, Takanobu Takeda Pharmaceutical Comp. Ltd. ,  KAWAMURA, Masaki Takeda Pharmaceutcal Comp. Ltd. ,  SAKAMOTO, Hiroki Takada Pharmaceutical Comp. Ltd.

IPC分类号： C07D277/42 ,  C07D513/04 ,  C07D417/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14 ,  A61K31/496 ,  A61K31/427 ,  A61K31/497 ,  A61P43/00 ,  A61P7/02 ,  A61P9/10 ,  A61P25/28

CPC分类号： C07D417/06 ,  C07D277/42 ,  C07D417/04 ,  C07D417/12

摘要： A thiazoline derivative represented by Formula (I):

wherein R is a cyclic hydrocarbon group which may be substituted, or a heterocyclic group which may be substituted; X is a bond or a divalent chain hydrocarbon group which may be substituted; X' is a bond or -N(R 5 )-; Y is a divalent hydrocarbon group which may be substituted; Y' is a bond or -C(=O)-; ring A is a nitrogen-containing heterocycle which may be substituted; Z 1 and Z 3 are each independently a bond or a divalent chain hydrocarbon group which may be substituted; Z 2 is a bond or -N(R 6 )-; and B is a group represented by the formula:

which is useful as a therapeutic drug for thrombosis, is provided.

摘要翻译： 由式（I）表示的噻唑啉衍生物：其中R是可被取代的环状烃基或可被取代的杂环基; X是可以被取代的键或二价链烃基; X'是键或-N（R 5） - ; Y是可以被取代的二价烃基; Y'是键或-C（= O） - ; 环A是可以被取代的含氮杂环; Z 1和Z 3各自独立地为可被取代的键或二价链烃基; Z 2是键或-N（R 6） - ; 并且B是由下式表示的基团：其可用作血栓形成的治疗药物。