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1.发明授权N-[5-({2-[(CYCLOPROPYLCARBONYL)AMINO]IMIDAZO[1,2-B]PYRIDAZIN-6-YL}OXY)-2-METHYLPHENYL]-1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXAMIDE AS VEGFR INHIBITOR 有权N- [5 - （{2 - [（环丙基羰基）氨基]咪唑并[1,2-b]哒嗪-6-基}氧基）-2-甲基苯基] -1,3-二甲基-1H-吡唑-5-甲酰胺 AS VEGFR抑制剂
公开(公告)号：EP2049541B1
公开(公告)日：2015-09-23
申请号：EP07792327.4
申请日：2007-08-03
IPC分类号： C07D487/04
CPC分类号： C07D487/04
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2.发明公开FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF 有权N- [5 - （{2 - [（环丙基羰基）氨基]咪唑并[1,2-b]哒嗪-6-基}氧基）-2-甲基苯基] -1,3-二甲基-1H-吡唑-5-甲酰胺 ALS VEGFR HEMMSTOFFE
公开(公告)号：EP2049541A2
公开(公告)日：2009-04-22
申请号：EP07792327.4
申请日：2007-08-03
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention provides a fused heterocyclic derivative having a potent kinase inhibitory activity and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the specification, except a particular compound, or a salt thereof, and a pharmaceutical agent containing the compound or a prodrug thereof, which is a kinase (VEGFR, VEGFR2, PDGFR, Raf) inhibitor, an angiogenesis inhibitor, an agent for the prophylaxis or treatment of cancer, a cancer growth inhibitor or a cancer metastasis suppressor.
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公开(公告)号：EP3896060A1
公开(公告)日：2021-10-20
申请号：EP19895161.8
申请日：2019-12-11
发明人： KAJITA, Yuichi , MIYANOHANA, Yuhei , KOIKE, Tatsuki , HOASHI, Yasutaka , HATTORI, Yasushi , TOKUNAGA, Norihito , ODA, Tsuneo , MIYAZAKI, Tohru , UYGHUR, Dilhumar , ITO, Yoshiteru , TAKEUCHI, Kohei , IMAMURA, Keisuke , SUGIMOTO, Takahiro , FUKUDA, Koichiro , KOHARA, Yasuhisa , OKAMOTO, Rei , OHRA, Taiichi , MIYAMOTO, Naoki , TERAO, Yoshito , KAWASAKI, Masanori
IPC分类号： C07D215/38 , A61K31/416 , A61K31/428 , A61K31/437 , A61K31/47 , A61K31/506 , A61P25/20 , A61P43/00 , C07D231/54 , C07D401/14 , C07D471/04
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):
wherein each symbol is as described in the description,
or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：EP3895707A1
公开(公告)日：2021-10-20
申请号：EP19895831.6
申请日：2019-12-11
发明人： MIYANOHANA, Yuhei , KAJITA, Yuichi , KOIKE, Tatsuki , HOASHI, Yasutaka , HATTORI, Yasushi , TOKUNAGA, Norihito , ODA, Tsuneo , MIYAZAKI, Tohru , UYGHUR, Dilhumar , ITO, Yoshiteru , TAKEUCHI, Kohei , IMAMURA, Keisuke , SUGIMOTO, Takahiro , FUKUDA, Koichiro , KOHARA, Yasuhisa , OKAMOTO, Rei , OHRA, Taiichi , MIYAMOTO, Naoki , CHIBA, Jun , TERAO, Yoshito , KAWASAKI, Masanori
IPC分类号： A61K31/437
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):
wherein each symbol is as described in the description, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：EP2915815A1
公开(公告)日：2015-09-09
申请号：EP13850534.2
申请日：2013-10-30
IPC分类号： C07F9/6512 , C07H21/02 , C12N15/09
CPC分类号： C07F9/65616 , C07D239/54 , C07D473/34 , C07F9/65121 , C07F9/65583 , C07F9/65586 , C07H21/00 , C07H21/02
摘要： Provided is an oligonucleic acid analog which contains, as at least one structural unit thereof, a modified nucleic acid monomer compound which is a ring-open nucleoside having a cleaved carbon-carbon bond between the 2' and 3' positions and a substituent hydroxymethyl group at the 4' position. When used as siRNA, the oligonucleic acid analog exhibits superior biological stability and target gene expression inhibiting activity. The oligonucleic acid analog can be used in antisense methods, ribozyme methods, and decoy methods, etc., can be used as a nucleic acid aptamer, and can also be used as a nucleic acid probe or molecular beacon, etc., or in genetic diagnostics, etc.
摘要翻译： 提供了作为其至少一个结构单元的寡核酸类似物，其具有在2'和3'位之间具有切割的碳 - 碳键的取代羟甲基的修饰的核酸单体化合物，其是开环核苷 在4'位置。 当用作siRNA时，寡核酸类似物表现出优异的生物学稳定性和靶基因表达抑制活性。 寡核酸类似物可用于反义方法，核酶方法和诱饵方法等，可用作核酸适体，也可用作核酸探针或分子信标等，或用于遗传 诊断等
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公开(公告)号：EP2915815B1
公开(公告)日：2018-01-17
申请号：EP13850534.2
申请日：2013-10-30
IPC分类号： C07F9/6512 , C07H21/02 , C12N15/09
CPC分类号： C07F9/65616 , C07D239/54 , C07D473/34 , C07F9/6512 , C07F9/65583 , C07F9/65586 , C07H21/00 , C07H21/02
摘要： Provided is an oligonucleic acid analog which contains, as at least one structural unit thereof, a modified nucleic acid monomer compound which is a ring-open nucleoside having a cleaved carbon-carbon bond between the 2' and 3' positions and a substituent hydroxymethyl group at the 4' position. When used as siRNA, the oligonucleic acid analog exhibits superior biological stability and target gene expression inhibiting activity. The oligonucleic acid analog can be used in antisense methods, ribozyme methods, and decoy methods, etc., can be used as a nucleic acid aptamer, and can also be used as a nucleic acid probe or molecular beacon, etc., or in genetic diagnostics, etc.
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