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公开(公告)号：EP4330229A1
公开(公告)日：2024-03-06
申请号：EP22721857.5
申请日：2022-04-25
发明人： YAMADA, Masatoshi , HIRANO, Sayuri , YABE, Osamu , KAJITA, Yuichi , ODA, Tsuneo , ABE, Takashi , YAMASHITA, Hironori
IPC分类号： C07D207/14 , C07D207/22
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2.发明公开FUSED TRIAZOLES FOR THE TREATMENT OR PROPHYLAXIS OF MILD COGNITIVE IMPAIRMENT 审中-公开简明三唑用于治疗或预防轻度认知障碍
公开(公告)号：EP2611805A1
公开(公告)日：2013-07-10
申请号：EP11791058.8
申请日：2011-09-01
发明人： KOIKE, Tatsuki , NAKAMURA, Minoru , TOMATA, Yoshihide , TAKAI, Takafumi , HOASHI, Yasutaka , KAJITA, Yuichi , TSUKAMOTO, Tetsuya , KAMATA, Makoto
IPC分类号： C07D471/04 , A61K31/4412 , A61K31/437 , A61P25/28
CPC分类号： C07D471/04
摘要： The present invention provides a heterocycle derivative having a superior amyloid β production inhibitory activity and/or a superior γ-secretase modulation activity, and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a salt thereof.
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公开(公告)号：EP3816153A1
公开(公告)日：2021-05-05
申请号：EP19825506.9
申请日：2019-06-27
发明人： ODA, Tsuneo , ITO, Yoshiteru , MIYAZAKI, Tohru , TAKEUCHI, Kohei , TOKUNAGA, Norihito , HOASHI, Yasutaka , HATTORI, Yasushi , IMAMURA, Keisuke , KAJITA, Yuichi , MIYANOHANA, Yuhei , SUGIMOTO, Takahiro , KOIKE, Tatsuki , UYGHUR, Dilhumar
IPC分类号： C07D207/14 , A61K31/40 , A61K31/426 , A61K31/4439 , A61K31/445 , A61P25/18 , A61P25/26 , C07D211/56 , C07D401/06 , C07D401/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D417/06 , C07D417/14
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):
wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：EP3594203A1
公开(公告)日：2020-01-15
申请号：EP18763726.9
申请日：2018-03-07
发明人： DAINI, Masaki , MIYANOHANA, Yuhei , MIKAMI, Satoshi , KAJITA, Yuichi , OGINO, Masaki , KOIKE, Tatsuki , TAKEUCHI, Kohei
IPC分类号： C07D207/12
摘要： The present invention provides a substituted pyrrolidine compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):
wherein each symbol is as described in the specification, or a salt thereof, has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：EP2933247B1
公开(公告)日：2018-08-29
申请号：EP13862252.7
申请日：2013-12-10
发明人： KOIKE, Tatsuki , KAJITA, Yuichi , YOSHIKAWA, Masato , IKEDA, Shuhei , KIMURA, Eiji , HASUI, Tomoaki , NISHI, Toshiya , FUKUDA, Hiromi
IPC分类号： C07D401/14 , C07D213/72 , C07D239/42 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , A61K31/444 , A61K31/46 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/55 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P43/00
CPC分类号： C07D498/08 , A61K9/2018 , A61K9/4858 , C07D213/12 , C07D213/72 , C07D213/74 , C07D239/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D451/02 , C07D451/04 , C07D471/08 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/18 , C07D491/08 , C07D491/18 , C12N9/99
摘要： An object of the present invention is to provide a compound having a superior CH24H inhibitory action, which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. The present invention relates to a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof.
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公开(公告)号：EP2982666A1
公开(公告)日：2016-02-10
申请号：EP14778814.5
申请日：2014-04-03
发明人： KOIKE, Tatsuki , YOSHIKAWA, Masato , ANDO, Haruhi , FARNABY, William John , IKEDA, Shuhei , KAJITA, Yuichi , NISHI, Toshiya
IPC分类号： C07D213/34 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P43/00 , C07D213/56 , C07D239/26 , C07D401/10 , C07D401/12
CPC分类号： C07D401/10 , C07D213/34 , C07D213/42 , C07D213/56 , C07D239/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to a compound represented by the formula (I), which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. In the formula (I), each symbol is as defined in the specification.
摘要翻译： 本发明涉及式（I）所示的化合物，其可用作预防或治疗癫痫，神经变性疾病等的药剂。 在式（I）中，每个符号如说明书中所定义。
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公开(公告)号：EP4066893A1
公开(公告)日：2022-10-05
申请号：EP20891800.3
申请日：2020-11-26
发明人： ITO, Yoshiteru , MIYANOHANA, Yuhei , KAJITA, Yuichi , HOASHI, Yasutaka , HATTORI, Yasushi , KOIKE, Tatsuki , TOKUNAGA, Norihito , KIMURA, Eiji , PAWLICZEK, Alexander Martin , PIRA, Marilena , MIGUELEZ-RAMOS, Javier
IPC分类号： A61P3/04 , A61P5/50 , A61P9/04 , A61P19/08 , A61P23/00 , A61P25/16 , A61P25/20 , A61P25/26 , A61P25/28 , A61P43/00 , C07D455/02 , C07D471/04 , A61K31/4375 , A61K31/444
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):
wherein each symbol is as described in the description, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：EP3917616A1
公开(公告)日：2021-12-08
申请号：EP20709748.6
申请日：2020-01-30
发明人： HATTORI, Yasushi , MIYANOHANA, Yuhei , KAJITA, Yuichi , KOIKE, Tatsuki , HOASHI, Yasutaka , TOKUNAGA, Norihito , PAWLICZEK, Alexander Martin , ODA, Tsuneo , MIYAZAKI, Tohru , ITO, Yoshiteru , TAKEUCHI, Kohei , IMAMURA, Keisuke , SUGIMOTO, Takahiro
IPC分类号： A61P3/00 , A61K31/40 , A61K31/4025 , A61K31/422 , A61K31/427 , A61K31/4439 , C07D207/14 , C07D401/10 , C07D403/10 , C07D403/14 , C07D407/06 , C07D413/10 , C07D417/10
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公开(公告)号：EP3896060A1
公开(公告)日：2021-10-20
申请号：EP19895161.8
申请日：2019-12-11
发明人： KAJITA, Yuichi , MIYANOHANA, Yuhei , KOIKE, Tatsuki , HOASHI, Yasutaka , HATTORI, Yasushi , TOKUNAGA, Norihito , ODA, Tsuneo , MIYAZAKI, Tohru , UYGHUR, Dilhumar , ITO, Yoshiteru , TAKEUCHI, Kohei , IMAMURA, Keisuke , SUGIMOTO, Takahiro , FUKUDA, Koichiro , KOHARA, Yasuhisa , OKAMOTO, Rei , OHRA, Taiichi , MIYAMOTO, Naoki , TERAO, Yoshito , KAWASAKI, Masanori
IPC分类号： C07D215/38 , A61K31/416 , A61K31/428 , A61K31/437 , A61K31/47 , A61K31/506 , A61P25/20 , A61P43/00 , C07D231/54 , C07D401/14 , C07D471/04
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):
wherein each symbol is as described in the description,
or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：EP3895707A1
公开(公告)日：2021-10-20
申请号：EP19895831.6
申请日：2019-12-11
发明人： MIYANOHANA, Yuhei , KAJITA, Yuichi , KOIKE, Tatsuki , HOASHI, Yasutaka , HATTORI, Yasushi , TOKUNAGA, Norihito , ODA, Tsuneo , MIYAZAKI, Tohru , UYGHUR, Dilhumar , ITO, Yoshiteru , TAKEUCHI, Kohei , IMAMURA, Keisuke , SUGIMOTO, Takahiro , FUKUDA, Koichiro , KOHARA, Yasuhisa , OKAMOTO, Rei , OHRA, Taiichi , MIYAMOTO, Naoki , CHIBA, Jun , TERAO, Yoshito , KAWASAKI, Masanori
IPC分类号： A61K31/437
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):
wherein each symbol is as described in the description, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.
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