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    FUSED HETEROCYCLIC COMPOUNDS
    3.
    发明公开
    FUSED HETEROCYCLIC COMPOUNDS 有权
    简明杂环化合物

    公开(公告)号：EP2601192A1

    公开(公告)日：2013-06-12

    申请号：EP11746717.5

    申请日：2011-08-03

    申请人： Takeda Pharmaceutical Company Limited

    发明人： RAKER, Joseph ,  TANIGUCHI, Takahiko ,  YOSHIKAWA, Masato ,  HASUI, Tomoaki ,  KUNITOMO, Jun

    IPC分类号： C07D471/04 ,  C07D471/14 ,  C07D519/00 ,  A61K31/437 ,  A61P25/18

    CPC分类号： C07D471/04 ,  C07D471/14 ,  C07D519/00

    摘要： The present invention provides a compound which has the effect of PDE 10A inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on. A compound represented by the formula (1'): wherein, Ring A' represents an optionally substituted pyridine ring, an optionally substituted pyridazine ring, a pyrimidine ring, or 10 a pyrazine ring, R1' represents (1) wherein, R
    1a' represents an optionally substituted phenyl group, or an optionally substituted 5- to 10-membered heterocyclic group, Ring B2 represents a bond, -S-, -0-, -CO-, an optionally substituted methylene group, or -NR
    a' - (R
    a' represents a hydrogen atom, or an optionally substituted C
    1-6 alkyl group), and Ring B
    1' represents an optionally further substituted 6- to 10- membered aromatic hydrocarbon ring, or an optionally further substituted 5- to 10-membered aromatic heterocyclic ring, or alternatively, L' and R
    1a' may be taken together to form an optionally substituted bicyclic or tricyclic fused heterocyclic group, or (2), wherein, R
    1b' represents an optionally substituted phenyl group, or an optionally substituted 5- to 10-membered heterocyclic group, Ring B
    2' represents an optionally substituted benzene ring, an optionally substituted pyridine ring, an optionally substituted pyrimidine ring, an optionally substituted pyrazine ring, or an optionally substituted pyridazine ring, Ring D' represents an optionally further substituted 5- or 6- membered ring, R
    2' represents a hydrogen atom, or a substituent, X' represents =N- or =CR
    b' - (R
    b' represents a hydrogen atom, or a substituent), _ _ _ _ _ represents that R
    b' and R
    2' may form, taken together with the carbon atom and the nitrogen atom to which they are each adjacent, an optionally substituted 5- to 7-membered ring when.X' is =CR
    b' -, or a salt thereof.