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公开(公告)号：EP3868384A1
公开(公告)日：2021-08-25
申请号：EP21157239.1
申请日：2017-12-01
Applicant: Takeda Pharmaceutical Company Limited
Inventor： YOSHIKAWA, Masato , SAITIH, Morihisa , KATO, Taisuke , YOSHITOMI, Yayoi , SEKI, Tomohiro , NAKAGAWA, Yasuo , TOMINARI, Yusuke , SETO, Masaki , SASAKI, Yusuke , OKANIWA, Masanori , ODA, Tsuneo , SHIBUYA, Akito , HIDAKA, Kosuke , SHIOKAWA, Zenyu , MURATA, Shumpei , OKABE, Atsutoshi , NAKADA, Yoshihisa , MOCHIZUKI, Michiyo , FREEZE, Brian Scott , TAWARAISHI, Taisuke , WADA, Yasufumi , GREENSPAN, Paul D.
IPC: A61K31/7084 , A61K31/7076 , A61K47/68 , C07H21/00 , C07H21/02 , A61P35/00
Abstract: The compound has Formula (XIV): (CD-L) n -A
n is 1-10; and
CD is a group represented by any one of Formula (XX) - (XXIX):-
2.发明授权
公开(公告)号：EP2763979B1
公开(公告)日：2018-12-26
申请号：EP12781479.6
申请日：2012-10-03
Applicant: Takeda Pharmaceutical Company Limited
Inventor： KOIKE, Tatsuki , YOSHIKAWA, Masato , ANDO, Haruhi , FARNABY, William John
IPC: C07D401/10 , C07D401/14 , C07D405/14 , C07D413/10 , C07D413/14 , C07D417/14 , C07D498/08 , A61K31/506 , A61K31/444 , A61P25/28
CPC classification number: C07D498/08 , C07D401/10 , C07D401/14 , C07D405/10 , C07D405/14 , C07D413/10 , C07D413/14 , C07D417/14
Abstract: The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.
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公开(公告)号：EP2927229A1
公开(公告)日：2015-10-07
申请号：EP13846269.2
申请日：2013-10-15
Applicant: Takeda Pharmaceutical Company Limited
Inventor： KOIKE, Tatsuki , YOSHIKAWA, Masato , NOMURA, Izumi , ITO, Yoshiteru , KIMURA, Eiji , HASUI, Tomoaki , ANDO, Haruhi , FUKUDA, Hiromi , NISHI, Toshiya
IPC: C07D413/04 , A61K31/422 , A61K31/437 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/553 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , A61P43/00 , C07D471/04 , C07D519/00
CPC classification number: C07D471/04 , C07D413/04 , C07D519/00
Abstract: The present invention provides a compound or a salt thereof useful for an agent for the prophylaxis or treatment of neurodegenerative disease and the like. The present invention relates to a compound represented by the formula
wherein each symbol is as defined in the present specification, or a salt thereof.Abstract translation: 本发明提供可用于预防或治疗神经退行性疾病等的药剂的化合物或其盐。 本发明涉及由下式表示的化合物或其盐，其中每个符号如本说明书中所定义。
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公开(公告)号：EP2602254A1
公开(公告)日：2013-06-12
申请号：EP11814684.4
申请日：2011-08-03
Applicant: Takeda Pharmaceutical Company Limited
Inventor： YOSHIKAWA, Masato , SUZUKI, Shinkichi , HASUI, Tomoaki , FUSHIMI, Makoto , KUNITOMO, Jun , KAMISAKI, Haruhi , TANIGUCHI, Takahiko
IPC: C07D401/14 , A61K31/501 , A61K31/5377 , A61K31/5386 , A61K31/553 , A61P3/00 , A61P3/04 , A61P3/10 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30
CPC classification number: C07D403/04 , A61K9/00 , A61K9/2018 , A61K9/2059 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D498/08
Abstract: The present invention provides a compound represented by the formula (1):
wherein each symbol is as defined in the specification,
or a salt thereof, a prodrug of the compound or a salt thereof, a medicament containing the compound or a salt thereof, the medicament which is a phosphodiesterase 10A inhibitor, and a medicament which is for preventing or treating schizophrenia.Abstract translation: 本发明提供由式（1）表示的化合物：其中各符号如说明书中所定义，或其盐，化合物或其盐的前药，含有该化合物或其盐的药物， 作为磷酸二酯酶10A抑制剂的药物，以及用于预防或治疗精神分裂症的药物。
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公开(公告)号：EP3366684B1
公开(公告)日：2020-09-02
申请号：EP16857592.6
申请日：2016-10-21
Applicant: Takeda Pharmaceutical Company Limited
Inventor： YOGO, Takatoshi , YOSHIKAWA, Masato , SAITOH, Morihisa , KATOH, Taisuke , SEKI, Tomohiro , NAKADA, Yoshihisa
IPC: C07D471/04 , A61K31/55 , C07D487/04 , C07D513/04 , A61K31/553 , C07D519/00 , A61K31/554 , A61P1/00 , A61P1/16 , A61P13/12 , A61P25/00 , A61P31/12 , A61P43/00
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Patent Agency Ranking
公开(公告)号：EP2982666B1
公开(公告)日：2019-08-07
申请号：EP14778814.5
申请日：2014-04-03
Applicant: Takeda Pharmaceutical Company Limited
Inventor： KOIKE, Tatsuki , YOSHIKAWA, Masato , ANDO, Haruhi , FARNABY, William John , IKEDA, Shuhei , KAJITA, Yuichi , NISHI, Toshiya
IPC: C07D213/34 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P43/00 , C07D213/56 , C07D239/26 , C07D401/10 , C07D401/12
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公开(公告)号：EP3187497A1
公开(公告)日：2017-07-05
申请号：EP15834925.8
申请日：2015-08-25
Applicant: Takeda Pharmaceutical Company Limited
Inventor： KAIEDA, Akira , ISHII, Naoki , NARA, Hiroshi , YOSHIKAWA, Masato , DAINI, Masaki , TOYOFUKU, Masashi , HIDAKA, Kousuke
IPC: C07D413/12 , A61K31/4245 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/55 , A61P29/00 , A61P35/00 , A61P37/06 , A61P43/00 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/107
CPC classification number: A61K31/4245 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/55 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/107
Abstract: The present invention provides a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of autoimmune diseases and/or inflammatory diseases, graft versus host disease, cancers, central nervous diseases including neurodegenerative diseases and the like, and a medicament comprising the compound.
The present invention relates to a compound represented by the formula (I):
wherein each symbol is as defined in the specification, or a salt thereof.Abstract translation: 本发明提供具有HDAC抑制作用并可用于治疗自身免疫性疾病和/或炎性疾病，移植物抗宿主病，癌症，中枢神经疾病包括神经退行性疾病等的杂环化合物，以及包含该化合物的药物 。 本发明涉及由式（I）表示的化合物或其盐，其中每个符号如说明书中所定义。
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公开(公告)号：EP2601192B1
公开(公告)日：2017-03-01
申请号：EP11746717.5
申请日：2011-08-03
Applicant: Takeda Pharmaceutical Company Limited
Inventor： RAKER, Joseph , TANIGUCHI, Takahiko , YOSHIKAWA, Masato , HASUI, Tomoaki , KUNITOMO, Jun
IPC: C07D471/04 , C07D471/14 , C07D519/00 , A61K31/437 , A61P25/18
CPC classification number: C07D471/04 , C07D471/14 , C07D519/00
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9.发明授权HETEROCYCLIC COMPOUND AND USE THEREOF INHIBITOR OF PHOSPHODIESTERASE 10A 有权HETEROCYCLISCHE VERBINDUNG UND IHRE VERWENDUNG ALS HEMMER DER PHOSPHODIESTERASE 10A
公开(公告)号：EP2604597B1
公开(公告)日：2017-01-04
申请号：EP11816444.1
申请日：2011-08-09
Applicant: Takeda Pharmaceutical Company Limited
Inventor： TANIGUCHI, Takahiko , SUZUKI, Shinkichi , YOSHIKAWA, Masato , HASUI, Tomoaki , FUSHIMI, Makoto , KUNITOMO, Jun
IPC: C07D401/04 , A61K31/4155 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61P25/18 , A61P43/00 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D417/14 , C07D491/048 , C07D498/04 , C07D401/14 , C07D413/14 , C07D409/04
CPC classification number: C07D498/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/048
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公开(公告)号：EP2933247A1
公开(公告)日：2015-10-21
申请号：EP13862252.7
申请日：2013-12-10
Applicant: Takeda Pharmaceutical Company Limited
Inventor： KOIKE, Tatsuki , KAJITA, Yuichi , YOSHIKAWA, Masato , IKEDA, Shuhei , KIMURA, Eiji , HASUI, Tomoaki , NISHI, Toshiya , FUKUDA, Hiromi
IPC: C07D213/74 , A61K31/444 , A61K31/4545 , A61K31/46 , A61K31/496 , A61K31/4995 , A61K31/506 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/55 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P43/00
CPC classification number: C07D498/08 , A61K9/2018 , A61K9/4858 , C07D213/12 , C07D213/72 , C07D213/74 , C07D239/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D451/02 , C07D451/04 , C07D471/08 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/18 , C07D491/08 , C07D491/18 , C12N9/99
Abstract: An object of the present invention is to provide a compound having a superior CH24H inhibitory action, which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. The present invention relates to a compound represented by the formula:
wherein each symbol is as defined in the specification, or a salt thereof.Abstract translation: 本发明的一个目的是提供一种具有优良CH24H抑制作用的化合物，其可用作预防或治疗癫痫，神经退行性疾病等的药剂。 本发明涉及由下式表示的化合物或其盐，其中每个符号如说明书中所定义。
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