公开(公告)号：EP2134360B1

公开(公告)日：2015-11-18

申请号：EP08782762.2

申请日：2008-03-14

申请人： Takeda Vaccines, Inc.

发明人： VEDVICK, Thomas S. ,  STEADMAN, Bryan ,  RICHARDSON, Charles ,  FOUBERT, Thomas R. ,  PETRIE, Charles R.

IPC分类号： C12N7/02 ,  A61K39/12

CPC分类号： A61K39/12 ,  C07K1/18 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/16023 ,  C12N2770/16034 ,  C12N2770/16051

公开(公告)号：EP2324113B8

公开(公告)日：2018-04-04

申请号：EP09805653.4

申请日：2009-08-10

申请人： Takeda Vaccines, Inc.

发明人： RICHARDSON, Charles ,  BARGATZE, Robert ,  HAYNES, Joel ,  STEADMAN, Bryan

IPC分类号： C12N7/01 ,  C07K14/00 ,  C07H21/00 ,  A61K39/12 ,  C07K14/08

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K47/36 ,  A61K2039/5258 ,  A61K2039/543 ,  A61K2039/55505 ,  A61K2039/55572 ,  A61K2039/55583 ,  A61K2039/70 ,  C12N7/00 ,  C12N2770/16022 ,  C12N2770/16023 ,  C12N2770/16034 ,  Y02A50/467

摘要： The present invention provides polypeptides having a composite amino acid sequence derived from a consensus sequence representing the capsid proteins of two or more circulating strains of a non-enveloped virus. In particular, the invention provides virus-like particles comprising at least one composite polypeptide. Such virus-like particles have antigenic epitopes of two or more circulating strains of a non-enveloped virus and produce an increase in antisera cross-reactivity to one or more circulating strains of the non-enveloped virus. Methods of making composite virus-like particles and vaccine formulations comprising composite virus-like particles are also disclosed.