公开(公告)号：EP2574188A1

公开(公告)日：2013-04-03

申请号：EP11783835.9

申请日：2011-05-19

申请人： Targacept, Inc. ,  AstraZeneca AB

发明人： DULL, Gary Maurice ,  GENUS, John ,  RATILAINEN, Tommi ,  RYBERG, Per Olof ,  HELLSTRÖM, Janna ,  WAHLSTRÖM, Niklas ,  WÄNNMAN, Thomas

IPC分类号： C07C29/40 ,  C07C211/21 ,  C07C231/14 ,  C07D213/65

CPC分类号： C07D213/65 ,  C07C29/36 ,  C07C211/21 ,  C07C269/04 ,  C07C33/03 ,  C07C271/12

摘要： An improved process for the preparation of aryl substituted olefinic amines such as (2S)-(4E)-N-methyl-5-[3-(5-isopropoxypyridin)yl]-4-penten-2-amine and (2S)-(4E)-N- methyl-5-[3-(5-methoxypyridin)yl]-4-penten-2-amine and new intermediates used in said process.

公开(公告)号：EP2155762B1

公开(公告)日：2011-10-12

申请号：EP08779297.4

申请日：2008-04-30

申请人： AstraZeneca AB

发明人： FINNHULT, Daniel ,  SOHLBERG, Roger ,  STÅLFORS, Fredrik ,  SVENSSON, Carina ,  WACHTMEISTER, Johanna ,  WÄNNMAN, Thomas

IPC分类号： C07F9/48

CPC分类号： C07F9/4808 ,  C07F9/4816

摘要： The present invention relates to a new process for the synthesis of alkyl phosphinic acids, and more particularly to a coupling reaction between an alkylhalide and a hypophosphorous acid derivative in the presence of an amine and an amineoxide.

公开(公告)号：EP2155762A1

公开(公告)日：2010-02-24

申请号：EP08779297.4

申请日：2008-04-30

申请人： AstraZeneca AB

发明人： FINNHULT, Daniel ,  SOHLBERG, Roger ,  STÅLFORS, Fredrik ,  SVENSSON, Carina ,  WACHTMEISTER, Johanna ,  WÄNNMAN, Thomas

IPC分类号： C07F9/30

CPC分类号： C07F9/4808 ,  C07F9/4816

摘要： The present invention relates to a new process for the synthesis of alkyl phosphinic acids, and more particularly to a coupling reaction between an alkylhalide and a hypophosphorous acid derivative in the presence of an amine and an amineoxide.