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    INTELLIGENT DRIPPING PILL MACHINE FOR CONTINUOUS LIQUID SOLIDIFICATION
    2.
    发明公开
    INTELLIGENT DRIPPING PILL MACHINE FOR CONTINUOUS LIQUID SOLIDIFICATION 审中-公开

    公开(公告)号：EP3351235A1

    公开(公告)日：2018-07-25

    申请号：EP16845724.0

    申请日：2016-09-14

    申请人： Tasly Pharmaceutical Group Co., Ltd.

    发明人： YAN, Kaijing ,  SUN, Xiaobing ,  RONG, Changsheng ,  CAI, Xuefei ,  WANG, Liang

    IPC分类号： A61J3/06

    CPC分类号： A61J3/06

    摘要： An intelligent dripping pill machine for continuous liquid solidification comprises: a feeding device (1), a material combining device (2), a homogenizing device (3), a dripping device (4) and a de-oiling device (5) sequentially connected via a transmission channel. The intelligent dripping pill machine removes, via high-speed centrifugation, a cooling liquid attached to dripping pills, and each component device is connected compactly, thereby achieving a continuous manufacturing operation, and reducing an occupied space of the devices as a whole while ensuring the yield of the dripping pills.

    INTELLIGENT CONTINUOUS MANUFACTURING METHOD VIA LIQUID COOLING OF DRIPPING PILLS
    3.
    发明公开
    INTELLIGENT CONTINUOUS MANUFACTURING METHOD VIA LIQUID COOLING OF DRIPPING PILLS 审中-公开

    公开(公告)号：EP3351234A1

    公开(公告)日：2018-07-25

    申请号：EP16845723.2

    申请日：2016-09-14

    申请人： Tasly Pharmaceutical Group Co., Ltd.

    发明人： YAN, Kaijing ,  SUN, Xiaobing ,  RONG, Changsheng ,  CAI, Xuefei ,  WANG, Liang

    IPC分类号： A61J3/06

    摘要： An intelligent continuous manufacturing method via liquid cooling of dripping pills comprises the following steps:(1) feeding: weighing and transferring multiple materials respectively; (2) material combining: performing staged heating on the materials transferred in step (1), and mixing the same to obtain a material mixture, wherein an RSD of an effective ingredient in the material mixture ≤5%; (3) homogenizing: pressurizing the material mixture obtained in step (2), and increasing the temperature, so as to obtain a homogenized material having the RSD of the effective ingredient in the material mixture ≤5%; (4) dripping: performing vibration dripping on the homogenized material obtained in step (3) to obtain dripping pills, delivering the dripping pills into a cooling liquid to be cooled and then transferred; and (5) de-oiling: removing the cooling liquid on surfaces of the dripping pills obtained in step (4) via tilting centrifugation. The manufacturing method not only shortens the manufacturing process, but also ensures the dripping pill product to be more stable and homogeneous. In addition, high-speed centrifugation is used to reasonably de-oil the dripping pills to prevent contamination of the dripping pills and improve the circulation utilization rate of the cooling liquid.

    AIR-COOLING DROP PILL PRODUCTION LINE
    4.
    发明公开
    AIR-COOLING DROP PILL PRODUCTION LINE 审中-公开
    PILLENFERTIGUNGSLINIE MITLUFTKÜHLUNGSTROPFEN

    公开(公告)号：EP3020387A1

    公开(公告)日：2016-05-18

    申请号：EP14822215.1

    申请日：2014-07-11

    申请人： Tasly Pharmaceutical Group Co., Ltd.

    发明人： YAN, Xijun ,  SUN, Xiaobing ,  ZHENG, Yongfeng ,  FAN, Lijun ,  FU, Yan

    IPC分类号： A61J3/06

    CPC分类号： A61J3/005 ,  A61J3/06 ,  A61J2200/42 ,  A61J2200/44 ,  B01J2/02 ,  B01J2/04 ,  B01J2/18

    摘要： An air-cooling drop pill production line comprises a drop pill system, an air-cooling circulation system and a control system. The drop pill system comprises a molten material tank and a dripper. A vibration apparatus is arranged between the molten material tank and the dripper, and drives the dripper to vibrate up and down. A vibration shear force cuts liquor flowing out from the dripper into drops, and drop pills are formed after the drops fall into the air-cooling circulation system and are cooled. An online monitoring apparatus is arranged on the dripper, and comprises a pulse signal emission mechanism with an emission frequency which is the same as a vibration frequency of the vibration apparatus. The control system controls and regulates a dropping parameter according to a monitoring result of the online monitoring apparatus. The present invention combines vibration dropping, online monitoring and controlling, air cooling, and fluidized drying and coating together, which satisfies the requirement of high-speed dropping, micro pill preparation and improving a drug-loading capacity. Thus, the drug-loading capacity of drop pills can be multiply improved, the usage of auxiliary materials and the dosage can be greatly reduced, organic solvent residual can be completely avoided, and requirements of different processes including slow-release coating, film coating and sugar coating can be satisfied.

    摘要翻译： 空气冷却滴丸生产线包括滴丸系统，空气冷却循环系统和控制系统。 滴丸系统包括熔融材料罐和滴液器。 在熔融材料罐和滴水器之间设置振动装置，驱动滴水器上下振动。 振动剪切力将从滴液器流出的液体切割成液滴，并且在液滴落入空气冷却循环系统中之后形成滴丸并冷却。 一种在线监测装置设置在滴液器上，包括具有与振动装置的振动频率相同的发射频率的脉冲信号发射机构。 控制系统根据在线监控设备的监控结果控制和调节丢弃参数。 本发明将振动降落，在线监测和控制，空气冷却，流化干燥和涂层结合在一起，满足高速滴下，微丸制备和提高载药能力的要求。 因此，滴丸的药物负载能力可以提高，辅料的用量和用量可以大大降低，有机溶剂残留可以完全避免，不同方法的要求包括缓释涂层，薄膜包衣和 糖衣可以满足。