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1.发明公开PREPARATION METHOD FOR TRADITIONAL CHINESE MEDICINE MICRO DROP PILL AND TRADITIONAL CHINESE MEDICINE MICRO DROP PILL PREPARED BY USING THE METHOD 审中-公开一种用于生产微滴丸BY TYPE中医杂志内及在微滴丸BY TYPE中医药的过程
公开(公告)号：EP3020395A1
公开(公告)日：2016-05-18
申请号：EP14823013.9
申请日：2014-07-11
发明人： YAN, Xijun , WU, Naifeng , YAN, Kaijing , SUN, Xiaobing , ZHANG, Shunnan , YE, Zhengliang , DONG, Hai'ou , ZHANG, Hongbo , ZHANG, Wensheng , ZHOU, Lihong , LI, Chenming , CHEN, Cong , LIU, Xiaofeng , WANG, Shiqing , RONG, Changsheng , ZHENG, Yongfeng , FAN, Lijun
CPC分类号： A61K9/2095 , A61J3/06 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/5015 , A61K9/5026 , A61K9/5042 , A61K9/5089 , A61K36/258 , A61K36/48 , A61K36/481 , A61K36/537 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a preparation method for a traditional Chinese medicine drop pill and a traditional Chinese medicine micro drop pill prepared by using the method, and in particular, the present invention relates to a micro drop pill preparation method with high drug-loading capacity, simple preparation process and high production rate and a micro drop pill prepared by using the method. Specially, The drop pill preparation method used comprises the following steps: (1) material melting step: heat melting a medicine and a drop pill matrix to obtain a molten medicine liquid; (2) dropping step: delivering the molten medicine liquid to a dripper, and acquiring medicine drops of the molten medicine liquid by means of vibration dropping; and, (3) condensation step: cooling the medicine drops with a cooling gas to obtain micro drop pills.
摘要翻译： 本发明涉及一种用于一个传统的中国医药滴丸，并通过使用该方法制备中国传统医药微滴丸的制备方法，并且特别地，本发明涉及具有高的药物负载能力的微型滴丸制备方法 ，制备工艺简单，生产率高，并通过使用所述方法制备的微滴丸。 特别地，所使用的滴丸制备方法包括以下步骤：（1）材料熔化步骤：加热熔融药物和滴丸矩阵以获得熔融液体药物; （2）滴加步骤：提供熔融的液体药物到滴流，并通过振动滴手段取得熔融液体药物的药滴; 和，（3）冷凝步骤：冷却所述药物与冷却气体，以获得微滴丸下降。
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2.发明公开TRADITIONAL CHINESE MEDICINE COMPOSITION, AND PREPARATION AND APPLICATION THEREOF 审中-公开物组成TYPE中医和生产及其使用
公开(公告)号：EP3020407A1
公开(公告)日：2016-05-18
申请号：EP14823384.4
申请日：2014-07-11
发明人： YAN, Xijun , WU, Naifeng , YAN, Kaijing , YE, Zhengliang , ZHANG, Shunnan , ZHOU, Lihong , ZHANG, Wensheng , DONG, Hai'ou , ZHENG, Yongfeng , FAN, Lijun
IPC分类号： A61K36/537 , A61K36/258 , A61K31/045 , A61K31/343 , A61K31/58 , A61K31/7048 , A61K9/20 , A61P9/10
CPC分类号： A61K36/537 , A61K9/5015 , A61K9/5026 , A61K9/5042 , A61K9/5089 , A61K31/045 , A61K31/11 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/343 , A61K31/704 , A61K36/258 , A61K2300/00
摘要： A traditional Chinese medicine composition for treating cardiovascular disease, and a preparation thereof, particularly a micro drop pill preparation thereof, and a method for preparing the preparation; the method for preparing the micro drop pill preparation can be used to prepare drop pills, coated drop pills, and drop pill capsules with a high drug loading capacity.
摘要翻译： 用于治疗心血管疾病传统的中国药物组合，以及它们的制备，特别是微滴丸及其制备方法，以及制备该制剂的方法; 用于制备微滴丸制备方法可用于制备降丸剂，包衣丸剂下降，滴丸胶囊具有高的载药能力。
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公开(公告)号：EP3011965B1
公开(公告)日：2020-05-06
申请号：EP14813421.6
申请日：2014-06-17
发明人： YAN, Xijun , ZHANG, Shunnan , YE, Zhengliang , ZHOU, Lihong , DONG, Hai'ou , ZHANG, Wensheng , ZHANG, Hongbo , MA, Changyu , ZHENG, Yongfeng , FAN, Lijun
IPC分类号： A61K36/537 , A61K9/16 , A61P9/14
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4.发明公开
公开(公告)号：EP3020408A1
公开(公告)日：2016-05-18
申请号：EP14823459.4
申请日：2014-07-11
发明人： YAN, Xijun , WU, Naifeng , YAN, Kaijing , YE, Zhengliang , ZHANG, Shunnan , ZHOU, Lihong , ZHANG, Wensheng , DONG, Hai'ou
IPC分类号： A61K36/537 , A61K36/258 , A61K31/704 , A61K31/343 , A61K31/192 , A61K31/11 , A61K31/045 , A61K9/20 , A61K9/10
CPC分类号： A61K31/704 , A61K9/16 , A61K9/1664 , A61K9/20 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2031 , A61K9/2059 , A61K9/2068 , A61K9/2893 , A61K31/045 , A61K31/11 , A61K31/192 , A61K31/216 , A61K31/343 , A61K36/258 , A61K36/537 , A61K36/82 , A61K2300/00
摘要： A traditional Chinese medicine composition for treating cardiovascular disease, and a preparation thereof, particularly a micro drop pill preparation thereof, and a method for preparing the preparation; the method for preparing the micro drop pill preparation can be used to prepare drop pills, coated drop pills, and drop pill capsules with a high drug loading capacity.
摘要翻译： 一种治疗心血管疾病的中药组合物及其制备方法，特别是一种微滴丸制剂及其制备方法， 该微滴丸制剂的制备方法可用于制备高载药量的滴丸，包衣滴丸和滴丸胶囊。
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5.发明公开TRADITIONAL CHINESE MEDICINE COMPOSITION 审中-公开ZUSAMMENSETZUNG NACH ART DER TRADITIONELLEN CHINESISCHEN MEDIZIN
公开(公告)号：EP3040077A1
公开(公告)日：2016-07-06
申请号：EP14840475.9
申请日：2014-08-28
发明人： YAN, Xijun , WU, Naifeng , ZHANG, Shunnan , LI, Ping , YE, Zhengliang , ZHOU, Lihong , QI, Lianwen , ZHANG, Fenglian , QI, Minchao , YANG, Zhexuan , SUN, Wei , YU, Jing , YANG, Hua , LIU, Peng , MA, Xiaohui , DONG, Hai'ou , ZHANG, Wensheng , ZHANG, Lanlan , LI, Chenming
IPC分类号： A61K31/704 , A61K36/537 , A61P9/10
CPC分类号： A61K31/192 , A61K31/11 , A61K31/216 , A61K31/343 , A61K31/352 , A61K31/7028 , A61K31/704 , A61K36/258 , A61K36/537 , A61K2300/00
摘要： A traditional Chinese medicine composition and preparation thereof for treating cardiovascular diseases is provided. The traditional Chinese medicine composition consists of: by weight percentage, phenolic aicd derivatives 30%∼80%, tanshinones 2%~10% and saponins 15%∼60%.
摘要翻译： 提供了一种治疗心血管疾病的中药组合物及其制备方法。 中药组合物为：按重量百分比计，酚类衍生物30％〜80％，丹参酮2％〜10％，皂苷15％〜60％。
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6.发明公开SALVIA MILTIORRHIZA EXTRACT, MICROPELLET FORMULATION THEREOF, METHODS OF PREPARING SAME, AND USES THEREOF 审中-公开丹参提取物，微球制剂其方法其生产及其用途
公开(公告)号：EP3011965A1
公开(公告)日：2016-04-27
申请号：EP14813421.6
申请日：2014-06-17
发明人： YAN, Xijun , ZHANG, Shunnan , YE, Zhengliang , ZHOU, Lihong , DONG, Hai'ou , ZHANG, Wensheng , ZHANG, Hongbo , MA, Changyu , ZHENG, Yongfeng , FAN, Lijun
IPC分类号： A61K36/537 , A61K9/16 , A61P9/14
摘要： A salvia miltiorrhiza extract, a micropellet formulation thereof, method of preparing same, and uses thereof are disclosed. The salvia miltiorrhiza extract contains the following component weight ratio: salvia miltiorrhiza element : rosmarinic acid : lithospermic acid : salvianolic acid B : cryptotanshinone : tanshinone IIA : stachyose=(0.5-16) : (0.5-15) : (0.5-15) : (5-140) : (0.5-25) : (1-50) : (150-600). The salvia miltiorrhiza extract of the present invention also contains a liposoluble active ingredient and a water-soluble active ingredient of salvia miltiorrhiza. The invention has excellent stability, contains low amounts of solvent residue, improves microcirculation and reduces blood lipid levels.
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