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1.发明授权
公开(公告)号：EP2359853B1
公开(公告)日：2013-11-06
申请号：EP10012457.7
申请日：2001-08-07
发明人： Neufeld, Gera , Akiri, Gal , Vadasz, Zahava , Gengrovitch, Stela
IPC分类号： A61K39/395
CPC分类号： C12Y104/03013 , A61K38/00 , C07K16/40 , C12N9/0022
摘要： A method of modulating angiogenesis in a mammalian tissue is provided. The method including administering into the mammalian tissue a molecule capable of modifying a tissue level and/or activity of at least one type of lysyl-oxidase to thereby modulate angiogenesis in the mammalian tissue.
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2.发明公开Pharmaceutical compositions and methods useful for modulating angiogenesis 有权Nützlichepharmazeutische Zusammensetzungen und VerfahrenfürAngiogenesemodulation
公开(公告)号：EP2359853A1
公开(公告)日：2011-08-24
申请号：EP10012457.7
申请日：2001-08-07
发明人： Neufeld, Gera , Akiri, Gal , Vadasz, Zahava , Gengrovitch, Stela
IPC分类号： A61K39/395
CPC分类号： C12Y104/03013 , A61K38/00 , C07K16/40 , C12N9/0022
摘要： A method of modulating angiogenesis in a mammalian tissue is provided. The method including administering into the mammalian tissue a molecule capable of modifying a tissue level and/or activity of at least one type of lysyl-oxidase to thereby modulate angiogenesis in the mammalian tissue.
摘要翻译： 提供调节哺乳动物组织中血管生成的方法。 所述方法包括向哺乳动物组织施用能够修饰至少一种类型的赖氨酰 - 氧化酶的组织水平和/或活性的分子，从而调节哺乳动物组织中的血管发生。
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公开(公告)号：EP2062919A3
公开(公告)日：2009-07-01
申请号：EP08020753.3
申请日：2003-11-27
发明人： Neufeld, Gera , Akiri, Gal , Vadasz, Zahava , Gengrovitch, Stela
IPC分类号： C07K16/40 , C12N9/06 , C12N15/53 , G01N33/574 , A61K39/395 , A61P35/00 , C12Q1/68
CPC分类号： C12Q1/6886 , A61K38/00 , A61K2039/505 , C07K16/30 , C07K16/40 , C12N9/0022 , C12Q1/26 , C12Y104/03013 , G01N33/574 , G01N33/57419 , G01N2500/00
摘要： Methods and compositions suitable for modulating angiogenesis in a mammalian tissue are provided. Further provided are methods suitable for inhibiting metastasis and fibrosis in a mammalian tissue and for assessing the malignancy of colon cancer tumors.
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4.发明授权
公开(公告)号：EP2078531B1
公开(公告)日：2012-05-30
申请号：EP08020754.1
申请日：2001-08-07
发明人： Neufeld, Gera , Akiri, Gal , Vadasz, Zhava , Gengrovitch, Stela
IPC分类号： A61K39/395
CPC分类号： C12Y104/03013 , A61K38/00 , C07K16/40 , C12N9/0022
摘要： A method of modulating angiogenesis in a mammalian tissue is provided. The method including administering into the mammalian tissue a molecule capable of modifying a tissue level and/or activity of at least one type of lysyl-oxidase to thereby modulate angiogenesis in the mammalian tissue.
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5.发明公开Pharmaceutical compositions and methods useful for modulating angiogenesis, inhibiting metastasis and tumor fibrosis, and assessing the malignancy of colon cancer tumors 有权有用的药物组合物和用于调制结肠癌的恶性肿瘤的血管生成，转移瘤和肿瘤抑制纤维化以及评估方法
公开(公告)号：EP2062919A2
公开(公告)日：2009-05-27
申请号：EP08020753.3
申请日：2003-11-27
发明人： Neufeld, Gera , Akiri, Gal , Vadasz, Zahava , Gengrovitch, Stela
IPC分类号： C07K16/40 , C12N9/06 , C12N15/53 , G01N33/574 , A61K39/395 , A61P35/00 , C12Q1/68
CPC分类号： C12Q1/6886 , A61K38/00 , A61K2039/505 , C07K16/30 , C07K16/40 , C12N9/0022 , C12Q1/26 , C12Y104/03013 , G01N33/574 , G01N33/57419 , G01N2500/00
摘要： Methods and compositions suitable for modulating angiogenesis in a mammalian tissue are provided. Further provided are methods suitable for inhibiting metastasis and fibrosis in a mammalian tissue and for assessing the malignancy of colon cancer tumors.
摘要翻译： 被提供的方法和适合于在哺乳动物组织调节血管生成的组合物。 提供进一步适合于转移抑制和纤维化在哺乳动物组织和用于assesing结肠癌肿瘤的恶性程度的方法。
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6.发明公开Pharmaceutical compositions and methods useful for modulating angiogenesis, inhibiting metastasis and tumor fibrosis, and assessing the malignancy of colon cancer tumors 审中-公开用于调节血管生成，抑制转移和肿瘤纤维化以及评估结肠癌肿瘤的恶性的药物组合物和方法
公开(公告)号：EP2062918A2
公开(公告)日：2009-05-27
申请号：EP08020752.5
申请日：2003-11-27
发明人： Neufeld, Gera , Akiri, Gal , Vadasz, Zahava , Gengrovitch, Stela
IPC分类号： C07K16/40 , C12N9/06 , C12N15/53 , A61K39/395 , A61P35/00 , G01N33/574 , C12Q1/68
CPC分类号： C12Q1/6886 , A61K38/00 , A61K2039/505 , C07K16/30 , C07K16/40 , C12N9/0022 , C12Q1/26 , C12Y104/03013 , G01N33/574 , G01N33/57419 , G01N2500/00
摘要： Methods and compositions suitable for modulating angiogenesis in a mammalian tissue are provided. Further provided are methods suitable for inhibiting metastasis and fibrosis in a mammalian tissue and for assessing the malignancy of colon cancer tumors.
摘要翻译： 提供了适用于调节哺乳动物组织中血管生成的方法和组合物。 进一步提供了适用于抑制哺乳动物组织中的转移和纤维化并评估结肠癌肿瘤的恶性程度的方法。
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公开(公告)号：EP2359854B1
公开(公告)日：2013-10-09
申请号：EP10012458.5
申请日：2001-08-07
发明人： Neufeld, Gera , Akiri, Gal , Vadasz, Zahava , Gengrovitch, Stela
IPC分类号： A61K39/395
CPC分类号： C12Y104/03013 , A61K38/00 , C07K16/40 , C12N9/0022
摘要： A method of modulating angiogenesis in a mammalian tissue is provided. The method including administering into the mammalian tissue a molecule capable of modifying a tissue level and/or activity of at least one type of lysyl-oxidase to thereby modulate angiogenesis in the mammalian tissue.
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8.发明公开
公开(公告)号：EP2078531A2
公开(公告)日：2009-07-15
申请号：EP08020754.1
申请日：2001-08-07
发明人： Neufeld, Gera , Akiri, Gal , Vadasz, Zhava , Gengrovitch, Stela
IPC分类号： A61K39/395
CPC分类号： C12Y104/03013 , A61K38/00 , C07K16/40 , C12N9/0022
摘要： A method of modulating angiogenesis in a mammalian tissue is provided. The method including administering into the mammalian tissue a molecule capable of modifying a tissue level and/or activity of at least one type of lysyl-oxidase to thereby modulate angiogenesis in the mammalian tissue.
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9.发明公开
公开(公告)号：EP2359854A1
公开(公告)日：2011-08-24
申请号：EP10012458.5
申请日：2001-08-07
发明人： Neufeld, Gera , Akiri, Gal , Vadasz, Zahava , Gengrovitch, Stela
IPC分类号： A61K39/395
CPC分类号： C12Y104/03013 , A61K38/00 , C07K16/40 , C12N9/0022
摘要： A method of modulating angiogenesis in a mammalian tissue is provided. The method including administering into the mammalian tissue a molecule capable of modifying a tissue level and/or activity of at least one type of lysyl-oxidase to thereby modulate angiogenesis in the mammalian tissue.
摘要翻译： 提供了调节哺乳动物组织中血管生成的方法。 该方法包括向哺乳动物组织中施用能够改变至少一种赖氨酰氧化酶的组织水平和/或活性的分子，从而调节哺乳动物组织中的血管生成。
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10.发明公开
公开(公告)号：EP2078531A3
公开(公告)日：2010-01-20
申请号：EP08020754.1
申请日：2001-08-07
发明人： Neufeld, Gera , Akiri, Gal , Vadasz, Zhava , Gengrovitch, Stela
IPC分类号： A61K39/395
CPC分类号： C12Y104/03013 , A61K38/00 , C07K16/40 , C12N9/0022
摘要： A method of modulating angiogenesis in a mammalian tissue is provided. The method including administering into the mammalian tissue a molecule capable of modifying a tissue level and/or activity of at least one type of lysyl-oxidase to thereby modulate angiogenesis in the mammalian tissue.
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