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1.发明授权
公开(公告)号：EP2359853B1
公开(公告)日：2013-11-06
申请号：EP10012457.7
申请日：2001-08-07
发明人： Neufeld, Gera , Akiri, Gal , Vadasz, Zahava , Gengrovitch, Stela
IPC分类号： A61K39/395
CPC分类号： C12Y104/03013 , A61K38/00 , C07K16/40 , C12N9/0022
摘要： A method of modulating angiogenesis in a mammalian tissue is provided. The method including administering into the mammalian tissue a molecule capable of modifying a tissue level and/or activity of at least one type of lysyl-oxidase to thereby modulate angiogenesis in the mammalian tissue.
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2.发明公开DIRECT APPLICATION OF NON-TOXIC CROSSLINKING REAGENTS TO RESIST PROGRESSIVE SPINAL DEGENERATION AND DEFORMITY 审中-公开直接应用没有毒性交联剂防御进行性脊髓变性和畸形的
公开(公告)号：EP2207509A4
公开(公告)日：2012-01-04
申请号：EP08780238
申请日：2008-07-06
申请人： ORTHOPEUTICS L P
发明人： HEDMAN THOMAS P , SLUSAREWICZ PAUL
IPC分类号： A61K38/44 , A61K31/11 , A61K31/131 , A61K31/353 , A61K31/70 , A61K38/45 , A61P19/04
CPC分类号： A61K31/70 , A61K38/063 , A61K38/44 , A61K38/45 , C12Y104/03013 , C12Y203/02013
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3.发明公开DIRECT APPLICATION OF NON-TOXIC CROSSLINKING REAGENTS TO RESTABILIZE SURGICALLY DESTABILIZED INTERVERTEBRAL JOINTS 审中-公开DIREKTE APPLIKATION VON NICHT-TOXISCHEN VERNETZUNGSREAGENTIEN ZUR RESTABILISIERUNG VON CHIRURGISCH DESTABILISIERTEN INTERVERTEBRALGELENKEN
公开(公告)号：EP2139495A4
公开(公告)日：2011-10-26
申请号：EP08726453
申请日：2008-03-04
申请人： ORTHOPEUTICS L P
发明人： HEDMAN THOMAS P
IPC分类号： A61K31/7048 , A61K31/11 , A61K31/7004 , A61L27/50 , A61L27/54
CPC分类号： A61K31/11 , A61K31/7004 , A61K33/40 , A61K38/39 , A61K38/443 , A61K38/45 , A61K45/06 , C12Y104/03013 , C12Y203/02013 , A61K2300/00
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4.发明公开
公开(公告)号：EP2179040A2
公开(公告)日：2010-04-28
申请号：EP08763709.6
申请日：2008-07-15
发明人： NEUFELD, Gera
IPC分类号： C12N15/11 , A61K31/713
CPC分类号： C07K16/40 , C07K2317/76 , C12N15/1137 , C12N2310/14 , C12N2310/531 , C12Q1/6883 , C12Q1/6886 , C12Q2600/158 , C12Y104/03013 , G01N33/573 , G01N2333/90638
摘要： The present disclosure provides pharmaceutical compositions and methods useful for modulating angiogenesis and for inhibiting metastasis, tumors, pulmonary alveolar proteinosis, and fibrosis in a mammalian tissue. Pharmaceutical compositions and methods include inhibitors of LOXL2 expression and activity, such as shRNA targeting LOXL2.
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5.发明公开METHOD AND COMPOSITION FOR TREATING AND PREVENTING TUMOR METASTASIS IN VIVO 审中-公开方法和组合物在体内治疗和预防肿瘤转移
公开(公告)号：EP2010224A2
公开(公告)日：2009-01-07
申请号：EP07749261.9
申请日：2007-01-25
发明人： ERLER, Janine , GIACCIA, Amato
CPC分类号： C12Q1/26 , A61K2039/505 , C07K16/40 , C07K2317/24 , C12N9/0022 , C12N15/1137 , C12N15/85 , C12N2310/11 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2830/002 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Y104/03013 , G01N33/574 , G01N2333/906 , G01N2500/04
摘要： Methods, compositions and kits are provided for effectively treating and preventing cancer metastasis in vivo and for increasing survival of subjects burdened with metastatic tumors by targeting a lysyl oxidase or its modulator, especially human lysyl oxidase. Also provided are methods for identifying lysyl oxidase inhibitors and the use of such inhibitors to prevent and treat tumors, particularly metastatic tumors, alone and in combination with chemotherapeutic agents. Further disclosed is the use of lysyl oxidase levels for measuring metastatic potential and survival.
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6.发明公开PHARMACEUTICAL COMPOSITIONS AND METHODS USEFUL FOR MODULATING ANGIOGENESIS, INHIBITING METASTASIS AND TUMOR FIBROSIS, AND ASSESSING THE MALIGNANCY OF COLON CANCER TUMORS 审中-公开有用的药物组合物和血管生成MOD，转移和抑制肿瘤纤维化和评估结肠癌的方法MALIGNITÜT
公开(公告)号：EP1572100A4
公开(公告)日：2008-04-02
申请号：EP03777136
申请日：2003-11-27
发明人： NEUFELD GERA , AKIRI GAL , VADASZ ZAHAVA , GENGRINOVITCH STELA
IPC分类号： C07K16/40 , A61K20060101 , A61K6/00 , A61K38/44 , A61K39/395 , A61K48/00 , A61P35/00 , C07K16/30 , C12N9/06 , C12N15/53 , C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , A61K38/00 , A61K2039/505 , C07K16/30 , C07K16/40 , C12N9/0022 , C12Q1/26 , C12Y104/03013 , G01N33/574 , G01N33/57419 , G01N2500/00
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7.发明授权
公开(公告)号：EP1261365B1
公开(公告)日：2006-09-20
申请号：EP01918377.1
申请日：2001-03-07
CPC分类号： A61L27/52 , A61K38/1709 , A61K38/1825 , A61K38/1841 , A61K38/1875 , A61K38/38 , A61K38/39 , A61K38/40 , A61K38/44 , A61K38/45 , A61K38/4873 , A61L27/227 , A61L27/26 , C12Y104/03013 , C12Y203/02013 , C12Y304/22015 , C08L89/00 , A61K2300/00
摘要： Disclosed is a product that enhances an attachment of connective tissue to bone. Also disclosed is a method of regenerating and repairing attachments of connective tissue to bone using such a product.
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8.发明公开
公开(公告)号：EP1315519A4
公开(公告)日：2005-09-14
申请号：EP01958338
申请日：2001-08-07
发明人： NEUFELD GERA , AKIRI GAL , VADASZ ZAHAVA , GENGROVITCH STELA
IPC分类号： A61K38/44 , A61K39/395 , A61K48/00 , A61P35/00 , C07K16/40 , C12N9/06 , C12N15/53 , A61K39/00
CPC分类号： C12Y104/03013 , A61K38/00 , C07K16/40 , C12N9/0022
摘要： A method of modulating angiogenesis in a mammalian tissue is provided. The method including administering into the mammalian tissue a molecule capable of modifying a tissue level and/or activity of at least one type of lysyl-oxidase to thereby modulate angiogenesis in the mammalian tissue.
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9.发明公开COMPOSITIONS AND METHODS FOR TREATING TUMORS, FIBROSIS, AND PULMONARY ALVEOLAR PROTEINOSIS 审中-公开组合物和方法用于治疗肿瘤，纤维化和肺泡的治疗
公开(公告)号：EP3075854A1
公开(公告)日：2016-10-05
申请号：EP16151497.1
申请日：2008-07-15
发明人： Neufeld, Gera
IPC分类号： C12N15/113 , C12Q1/68 , A61K31/713 , C07K16/40 , A61K39/395 , A61P11/00
CPC分类号： C07K16/40 , C07K2317/76 , C12N15/1137 , C12N2310/14 , C12N2310/531 , C12Q1/6883 , C12Q1/6886 , C12Q2600/158 , C12Y104/03013 , G01N33/573 , G01N2333/90638
摘要： The present disclosure provides pharmaceutical compositions and methods useful for modulating angiogenesis and for inhibiting metastasis, tumors, pulmonary alveolar proteinosis, and fibrosis in a mammalian tissue. Pharmaceutical compositions and methods include inhibitors ofLOXL2 expression and activity, such as shRNA targeting LOXL2.
摘要翻译： 本公开提供药物组合物和用于在哺乳动物组织调节血管生成和转移抑制为，肿瘤，肺泡蛋白沉积症，和纤维化有用的方法。 药物组合物和方法包括抑制剂ofLOXL2表达和活性，颜色：如shRNA的靶向LOXL2。
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公开(公告)号：EP2126060B1
公开(公告)日：2016-10-05
申请号：EP08717945.3
申请日：2008-03-18
申请人： DSM IP Assets B.V.
发明人： DIJK, VAN, Albertus, Alard , DEKKER, Petrus, Jacobus, Theodorus , WESTERLAKEN, Ilja , BAKHUIS, Janna Gardina
CPC分类号： A23J3/08 , A23J3/14 , A23J3/22 , A23L7/107 , A23L29/06 , C12N9/0022 , C12Y104/03013
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