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1.发明授权MONOCLONAL ANTIBODY SPECIFIC TO MAJOR NEUTRALIZING EPITOPE OF INFLUENZA H5 HEMAGGLUTININ 有权流感H5血凝素特异性单克隆抗体的重要中和表位
公开(公告)号：EP2609113B1
公开(公告)日：2017-03-22
申请号：EP10856496.4
申请日：2010-08-23
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/76
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2.发明公开
公开(公告)号：EP2920207A1
公开(公告)日：2015-09-23
申请号：EP13855450.6
申请日：2013-08-23
CPC分类号： C07K16/1018 , A61K2039/505 , A61K2039/544 , A61K2039/545 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/76 , G01N33/56983 , G01N2333/11
摘要： The present invention relates to the murine monoclonal antibody (mAb) 11B9 and to mAb 62 each of which target major neutralizing epitopes of influenza A H7 hemagglutinin and active fragments thereof. The present invention also relates to methods and compositions for the prophylaxis and treatment of H7 influenza using murine mAb 11B9, mAb 62 or fragments thereof. The present invention further relates to methods and kits for determining, identifying and/or quantifying (a) influenza A hemagglutinin in a sample or vaccine or (b) an antibody against influenza A hemagglutinin.
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3.发明授权MONOCLONAL ANTIBODIES SPECIFIC TO HEMAGGLUTININ AND NEURAMINIDASE FROM INFLUENZA VIRUS H5-SUBTYPE OR N1-SUBTYPE AND USES THEREOF 有权血凝素和神经氨酸酶特异性单克隆抗体H5甲型类型下，N1下的流感病毒类型及其用途
公开(公告)号：EP2201039B1
公开(公告)日：2015-07-15
申请号：EP08830693.1
申请日：2008-09-12
发明人： QIAN, Hong Liang , HE, Fang , KWANG, Hwei-Sing
IPC分类号： C07K16/10 , A61K39/145 , A61P31/16 , C12N7/00 , G01N33/53 , G01N33/577
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/34 , C07K2317/76 , C12N2760/16111 , G01N33/56983 , G01N2333/11
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公开(公告)号：EP3348568B1
公开(公告)日：2019-05-15
申请号：EP18158352.7
申请日：2013-08-23
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5.发明授权
公开(公告)号：EP2920207B1
公开(公告)日：2018-03-21
申请号：EP13855450.6
申请日：2013-08-23
CPC分类号： C07K16/1018 , A61K2039/505 , A61K2039/544 , A61K2039/545 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/76 , G01N33/56983 , G01N2333/11
摘要： The present invention relates to the murine monoclonal antibody (mAb) 11B9 and to mAb 62 each of which target major neutralizing epitopes of influenza A H7 hemagglutinin and active fragments thereof. The present invention also relates to methods and compositions for the prophylaxis and treatment of H7 influenza using murine mAb 11B9, mAb 62 or fragments thereof. The present invention further relates to methods and kits for determining, identifying and/or quantifying (a) influenza A hemagglutinin in a sample or vaccine or (b) an antibody against influenza A hemagglutinin.
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6.发明公开MONOCLONAL ANTIBODIES SPECIFIC TO HEMAGGLUTININ AND NEURAMINIDASE FROM INFLUENZA VIRUS H5-SUBTYPE OR N1-SUBTYPE AND USES THEREOF 审中-公开特异性单克隆抗体血凝素和神经氨酸酶流感病毒H5亚型或N1亚型及其用途
公开(公告)号：EP2947094A1
公开(公告)日：2015-11-25
申请号：EP15176239.0
申请日：2008-09-12
发明人： QIAN, Hong Liang , HE, Fang , KWANG, Hwei-sing
IPC分类号： C07K16/10 , A61K39/145 , A61P31/16 , C12N7/00 , G01N33/53 , G01N33/577
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/34 , C07K2317/76 , C12N2760/16111 , G01N33/56983 , G01N2333/11
摘要： Monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes or neuraminidase glycoprotein of N1 subtypes of avian influenza virus (AIV) are provided. The monoclonal antibodies and related binding proteins are useful for the detection of H5 and N1 subtypes of AIV, including H5N1 subtypes and provide means for the diagnosis, surveillance and treatment of dangerous viral infections.
摘要翻译： 单克隆抗体及相关的结合蛋白没有特异性结合H5亚型禽流感或流感病毒（AIV）的N1亚型神经氨酸酶糖蛋白的包膜糖蛋白提供。 单克隆抗体和相关结合蛋白的检测H5禽流感病毒和N1的亚型，包括H5N1亚型有用的，并为危险病毒感染的诊断，监测和治疗手段。
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7.发明公开MONOCLONAL ANTIBODIES SPECIFIC TO HEMAGGLUTININ FROM INFLUENZA VIRUS H5-SUBTYPE AND USES THEREOF 有权对于特殊H5血凝素单克隆抗体从分型流感病毒及其用途
公开(公告)号：EP2207804A1
公开(公告)日：2010-07-21
申请号：EP08830488.6
申请日：2008-08-26
申请人： Temasek Life Sciences Laboratory Limited , National Institute of Health Research and Development (NIHRD) - Ministry of Health of The Republic of Indonesia
IPC分类号： C07K16/10 , A61K39/145 , A61K39/42 , C12N7/00 , C12P21/00 , C12P21/08 , G01N33/53 , G01N33/569
CPC分类号： C07K16/1018 , A61K39/42 , C07K2317/24 , C07K2317/76 , C12N2760/16111 , G01N33/56983 , G01N2333/11
摘要： Monoclonal antibodies and related binding proteins that are specific for conformational epitopes of avian influenza virus K5 subtype hemagglutinin glycoprotein are provided. The antibodies can be used for the detection and treatment of H5 subtype AIV in specimens.
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8.发明公开MONOCLONAL ANTIBODIES SPECIFIC TO HEMAGGLUTININ AND NEURAMINIDASE FROM INFLUENZA VIRUS H5-SUBTYPE OR N1-SUBTYPE AND USES THEREOF 有权血凝素和神经氨酸酶特异性单克隆抗体H5甲型类型下，N1下的流感病毒类型及其用途
公开(公告)号：EP2201039A1
公开(公告)日：2010-06-30
申请号：EP08830693.1
申请日：2008-09-12
发明人： QIAN, Hong Liang , HE, Fang , KWANG, Hwei-Sing
IPC分类号： C07K16/10 , A61K39/145 , A61P31/16 , C12N7/00 , G01N33/53 , G01N33/577
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/34 , C07K2317/76 , C12N2760/16111 , G01N33/56983 , G01N2333/11
摘要： Monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes or neuraminidase glycoprotein of N1 subtypes of avian influenza virus (AIV) are provided. The monoclonal antibodies and related binding proteins are useful for the detection of H5 and N1 subtypes of AIV, including H5N1 subtypes and provide means for the diagnosis, surveillance and treatment of dangerous viral infections.
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9.发明公开H5 SUBTYPE-SPECIFIC BINDING PROTEINS USEFUL FOR H5 AVIAN INFLUENZA DIAGNOSIS AND SURVEILLANCE 审中-公开具体参与诊断和监测禽流感H5 SUITABLE的H5类型下结合蛋白
公开(公告)号：EP2155787A1
公开(公告)日：2010-02-24
申请号：EP07748679.3
申请日：2007-05-11
发明人： HO, Yuen Fern , DU, Qing Yun , HE, Fang , KWANG, Jimmy Hwei-Sing
IPC分类号： C07K16/10 , G01N33/53 , G01N33/569 , C12N15/00 , G01N33/563 , G01N33/577
CPC分类号： G01N33/56983 , C07K16/1018 , C07K2317/34 , C07K2317/76 , G01N2333/11
摘要： The invention provides monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes of avian influenza virus ('AIV'). The monoclonal antibodies and related binding proteins are useful for the detection of H5 subtypes of AIV, including the pathogenic H5N1 subtypes. Virus may be detected in formalin preserved, paraffin embeded specimens as well as frozen specimens and biological fluids. Accordingly, the invention provides means for the diagnosis and surveillance of dangerous viral infections.
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公开(公告)号：EP2947094B1
公开(公告)日：2018-11-14
申请号：EP15176239.0
申请日：2008-09-12
发明人： QIAN, Hong Liang , HE, Fang , KWANG, Hwei-sing
IPC分类号： C07K16/10 , A61K39/145 , A61P31/16 , C12N7/00 , G01N33/53 , G01N33/577
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/34 , C07K2317/76 , C12N2760/16111 , G01N33/56983 , G01N2333/11
摘要： Monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes or neuraminidase glycoprotein of N1 subtypes of avian influenza virus (AIV) are provided. The monoclonal antibodies and related binding proteins are useful for the detection of H5 and N1 subtypes of AIV, including H5N1 subtypes and provide means for the diagnosis, surveillance and treatment of dangerous viral infections.
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