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    PROCESS FOR PREPARING 2-(PYRIDINYL)METHYL SULFINYL-SUBSTITUTED BENZIMIDAZOLES AND NOVEL CHLORINATED DERIVATIVES OF PANTOPRAZOLE
    1.
    发明公开
    PROCESS FOR PREPARING 2-(PYRIDINYL)METHYL SULFINYL-SUBSTITUTED BENZIMIDAZOLES AND NOVEL CHLORINATED DERIVATIVES OF PANTOPRAZOLE 审中-公开
    用于生产（吡啶基）甲基亚磺酰基的苯并咪唑取代的和泮托拉唑的新氯化衍生物

    公开(公告)号：EP1615913A2

    公开(公告)日：2006-01-18

    申请号：EP04755278.1

    申请日：2004-06-10

    申请人： Teva Pharmaceutical Industries Limited

    发明人： LIBERMAN, Anita ,  SINGER, Claude ,  RAIZI, Yuriy ,  PILARSKY; Gideon ,  BRAUDE, Viviana ,  FINKELSTEIN, Nina ,  CHEN, Kobi

    IPC分类号： C07D401/12

    CPC分类号： C07D401/12

    摘要： The present invention provides a process comprising admixing a thioether with about 1.05 to about 1.6 molar equivalents of an active chlorine-containing oxidant, preferably sodium hypochlorite, and about 2.5 to about 5.0 molar equivalents of an alkali metal base; and recovering a sulfoxide that is preferably pantoprazole, lansoprazole, omeprazole, or rabeprazole. The process may further comprise contacting the sulfoxide with a source of sodium ions, preferably sodium hydroxide, to produce the sodium salt of the sulfoxide. The invention also relates to novel chlorinated derivatives of pantoprazole including 5­(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)-chloromethyl]sulfinyl]-1H- benzimidazole and 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)­chlorohydroxymethyl] sulfinyl]-1H-benzimidazole and processes for making them. The invention also relates to processes of quantifying and identifying a compound other than pantoprazole in a mixture of pantoprazole and at least one other compound.