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公开(公告)号：EP1881954A2
公开(公告)日：2008-01-30
申请号：EP06760041.1
申请日：2006-05-16
发明人： LIFSHITZ-LIRON, Revital , EISENSTADT, Amihai , WIZEL, Shlomit , AVHAR-MAYDAN, Sharon , RAIZI, Yuriy , RAMATY, Revital
IPC分类号： C07C209/08 , C07C209/22 , C07C211/30
CPC分类号： C07C209/08 , C07B2200/07 , C07C209/16 , C07C209/22 , C07C211/30
摘要： Processes for preparing cinacalcet are provided.
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公开(公告)号：EP1784398A1
公开(公告)日：2007-05-16
申请号：EP05796114.6
申请日：2005-09-02
发明人： HEDVATI, Lilach , PILARSKY, Gideon , RAIZI, Yuriy , MAROM, Esti
IPC分类号： C07D403/10
CPC分类号： C07D405/14
摘要： The present invention provides a process for purifying olmesartan medoxomil.
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公开(公告)号：EP1881954B1
公开(公告)日：2009-09-16
申请号：EP06760041.1
申请日：2006-05-16
发明人： LIFSHITZ-LIRON, Revital , EISENSTADT, Amihai , WIZEL, Shlomit , AVHAR-MAYDAN, Sharon , RAIZI, Yuriy , RAMATY, Revital
IPC分类号： C07C209/08 , C07C209/22 , C07C211/30
CPC分类号： C07C209/08 , C07B2200/07 , C07C209/16 , C07C209/22 , C07C211/30
摘要： Processes for preparing cinacalcet are provided.
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公开(公告)号：EP1805135A2
公开(公告)日：2007-07-11
申请号：EP06771214.1
申请日：2006-05-23
IPC分类号： C07C271/12 , C07C211/30 , C07C209/84 , A61K31/137 , A61P5/14
CPC分类号： C07C209/84 , C07C209/90 , C07C271/12 , C07C211/30 , C07C211/63
摘要： Isolated cinacalcet carbamate, processes for the preparation thereof, and processes for the use of cinacalcet carbamate as a reference marker and standard are provided. Also provided are cinacalcet salts substantially free of cinacalcet carbamate, and processes for the preparation thereof.
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5.发明公开STEREOSELECTIVE ENZYMATIC SYNTHESIS OF (S) OR (R)-ISO-BUTYL-GLUTARIC ESTER 审中-公开立体选择性酶法合成（S） - 或 （R）-ISO丁基戊二酸
公开(公告)号：EP2297090A1
公开(公告)日：2011-03-23
申请号：EP09770877.0
申请日：2009-06-23
IPC分类号： C07C229/08 , C07C69/42 , C12P41/00
CPC分类号： C07C229/08 , C12P7/62 , C12P41/005
摘要： The present invention relates to a stereoselective enzymatic synthesis of (S) or (R)-iso-butyl-glutaric ester, an intermediate of S-Pregabalin.
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6.发明公开PREGABALIN FREE OF ISOBUTYLGLUTARIC ACID AND A PROCESS FOR PREPARATION THEREOF 审中-公开ISOBUTYLGLUTARSÄUREFREIES普瑞巴林及其制备方法
公开(公告)号：EP1879853A1
公开(公告)日：2008-01-23
申请号：EP06759584.3
申请日：2006-05-10
发明人： HEDVATI, Lilach , DEE NOOR, Ziv , SINGER, Claude , PILARSKI, Gideon , RAIZI, Yuriy , TOMER, Sharon
IPC分类号： C07C229/08 , A61K31/197 , A61P25/08
CPC分类号： C07C227/40 , C07C227/42 , C07C229/08
摘要： A Pregabalin having a low level of 3-isobutylglutaric acid is provided.
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7.发明公开
公开(公告)号：EP1879852A1
公开(公告)日：2008-01-23
申请号：EP06749676.0
申请日：2006-04-11
发明人： HEDVATI, Lilach , PILARSKI, Gideon , RAIZI, Yuriy , TOMER, Sharon , DEE NOOR, Ziv , SINGER, Claude
IPC分类号： C07C229/08 , A61K31/197 , A61P25/00 , G01N30/00
CPC分类号： C07C229/08 , G01N30/8675 , G01N2030/027 , G01N2030/8813 , G01N2030/8818
摘要： The present invention encompasses Pregabalin substantially free of Lactam and a process for obtaining Pregabalin substantially free of Lactam comprising extracting an acidic mixture containing a complex of Pregabalin with a strong mineral acid, with a C3-8 alcohol; and combining the organic phase with an organic base.
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