公开(公告)号：EP3383841A1

公开(公告)日：2018-10-10

申请号：EP16871454.1

申请日：2016-11-30

申请人： The Arizona Board of Regents On Behalf of the University of Arizona

发明人： HURLEY, Laurence ,  GOKHALE, Vijay ,  KANG, HyunJin ,  WU, Kui

IPC分类号： C07C275/54 ,  A01N47/34 ,  A61K31/17 ,  C07D401/12

CPC分类号： C07C275/54 ,  A61P35/00 ,  C07D219/08 ,  C07D239/34 ,  C07D239/52 ,  C07D241/18 ,  C07D295/088 ,  C07D401/12 ,  C07D403/04

摘要： The present invention provides hTERT modulators and methods for producing and using the same. In particular, the present invention provide a compound of the formula as described herein. Some aspects of the invention are based on the characterization of the effect of hTERT core promoter region mutants on the 5-12 G-quadruplex structure and its stability. It is believed that some of the compounds of the invention bind selectively to the G-quadruplex in the hTERT core promoter mutant, which results in reversal of the effect of mutant promoter activation.