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公开(公告)号：EP3383841A1
公开(公告)日：2018-10-10
申请号：EP16871454.1
申请日：2016-11-30
发明人： HURLEY, Laurence , GOKHALE, Vijay , KANG, HyunJin , WU, Kui
IPC分类号： C07C275/54 , A01N47/34 , A61K31/17 , C07D401/12
CPC分类号： C07C275/54 , A61P35/00 , C07D219/08 , C07D239/34 , C07D239/52 , C07D241/18 , C07D295/088 , C07D401/12 , C07D403/04
摘要： The present invention provides hTERT modulators and methods for producing and using the same. In particular, the present invention provide a compound of the formula as described herein. Some aspects of the invention are based on the characterization of the effect of hTERT core promoter region mutants on the 5-12 G-quadruplex structure and its stability. It is believed that some of the compounds of the invention bind selectively to the G-quadruplex in the hTERT core promoter mutant, which results in reversal of the effect of mutant promoter activation.
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2.发明公开N-ACYLTHIOUREES ET N-ACYLUREES INHIBITEURS DE LA VOIE DE SIGNALISATION DES PROTEINES HEDGEHOG 有权N-ACYLTHIOHARNSTOFF- UND N-ACYLHARNSTOFFVERBINDUNGEN ALS INHIBITOREN DES HEDGEHOG-PROTEIN-SIGNALPFADES
公开(公告)号：EP2291352A2
公开(公告)日：2011-03-09
申请号：EP09733789.3
申请日：2009-04-16
发明人： RUAT, Martial , FAURE, Hélène , TRAIFFORT, Elisabeth , SCHOENFELDER, Angèle , MANN, André , TADDEI, Maurizio , SOLINAS, Antonio , MANETTI, Fabrizio
IPC分类号： C07C335/26 , C07C275/54 , C07D213/81 , C07D307/68 , C07D317/68 , C07D319/18 , C07D333/38 , A61K31/17 , C07D209/06 , C07D235/14 , A61P3/10 , A61P25/00
CPC分类号： C07C335/26 , C07C275/54 , C07C335/08 , C07C2601/14 , C07D209/08 , C07D209/14 , C07D213/81 , C07D235/14 , C07D235/18 , C07D307/68 , C07D317/68 , C07D319/18 , C07D333/38 , C07D471/04 , C07D513/04
摘要： The present invention relates to the use of acylthiourea or acylurea derivatives for the treatment of pathologies involving a tissue dysfunction associated with a deregulation of the Hedgehog protein signalling pathway, and also to novel acylthiourea or acylurea derivatives as such, to their use as a medicinal product, and to pharmaceutical compositions containing them.
摘要翻译： 本发明涉及酰基硫脲或酰基脲衍生物用于治疗涉及与Hedgehog蛋白信号传导途径失调相关的组织功能障碍的病理学，以及新的酰基硫脲或酰基脲衍生物作为药用产品的用途 ，以及含有它们的药物组合物。
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3.发明授权CARBOXYALKOXY-SUBSTITUIERTE ACYL-CARBOXYPHENYL-HARNSTOFFDERIVATE, VERFAHREN ZU IHRE HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL 有权羧基烷氧基 - 取代的酰基羧基苯基脲衍生物，进程中为其及其作为药物
公开(公告)号：EP1556339B1
公开(公告)日：2010-09-01
申请号：EP03757879.6
申请日：2003-09-22
发明人： DEFOSSA, Elisabeth , KADEREIT, Dieter , KLABUNDE, Thomas , BURGER, Hans-Joerg , HERLING, Andreas , WENDT, Karl-Ulrich , VON REODERN, Erich , SCHOENAFINGER, Karl , ENHSEN, Alfons
IPC分类号： C07C275/54 , A61K31/17 , A61P3/10
CPC分类号： C07C275/54
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4.发明授权CARBONYLAMINO-SUBSTITUIERTE ACYL-PHENYL-HARNSTOFFDERIVATE, VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG 有权羰基氨基取代的酰基苯基脲衍生物，用于生产及其用途
公开(公告)号：EP1590322B1
公开(公告)日：2009-09-23
申请号：EP04700448.6
申请日：2004-01-07
发明人： DEFOSSA, Elisabeth , KADEREIT, Dieter , KLABUNDE, Thomas , BURGER, Hans-Joerg , HERLING, Andreas , WENDT, Karl-Ulrich , VON ROEDERN, Erich , SCHOENAFINGER, Karl , ENHSEN, Alfons
IPC分类号： C07C275/54 , C07D213/56 , C07D307/56 , C07D333/26 , A61K31/17 , A61K31/33
CPC分类号： C07D213/82 , C07C275/54 , C07C2601/04 , C07D209/12 , C07D295/033 , C07D307/68 , C07D307/85 , C07D333/38
摘要： The invention relates to compounds of formula (I) wherein the radicals have the cited meaning, in addition to the physiologically compatible salts thereof. The compounds, for example, can be used as medicaments for preventing and treating type 2 diabetes.
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5.发明授权N-BENZOYLUREIDO-ZIMTS UREDERIVATE, VERFAHREN ZU DEREN HERSTE LLUNG UND DEREN VERWENDUNG 有权的N- BENZOYLUREIDO肉桂酸衍生物，herste填充过程及其用途
公开(公告)号：EP1513800B1
公开(公告)日：2006-11-15
申请号：EP03732438.1
申请日：2003-05-22
发明人： SCHOENAFINGER, Karl , DEFOSSA, Elisabeth , KADEREIT, Dieter , VON ROEDERN, Erich , KLABUNDE, Thomas , BURGER, Hans-Joerg , HERLING, Andreas , WENDT, Karl-Ulrich
IPC分类号： C07C275/54 , A61P3/10 , A61K31/17 , A61K31/19
CPC分类号： C07C275/54
摘要： The invention relates to N-benzoylureidocinnamate derivatives of formula (I), where R1-R11 have the meanings given in the claims, the physiologically acceptable salts and method for production thereof. The compounds are suitable as anti-diabetics, for example.
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6.发明公开CARBONYLAMINO-SUBSTITUIERTE ACYL-PHENYL-HARNSTOFFDERIVATE, VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG 有权羰基氨基取代的酰基苯基脲衍生物，用于生产及其用途
公开(公告)号：EP1590322A1
公开(公告)日：2005-11-02
申请号：EP04700448.6
申请日：2004-01-07
发明人： DEFOSSA, Elisabeth , KADEREIT, Dieter , KLABUNDE, Thomas , BURGER, Hans-Joerg , HERLING, Andreas , WENDT, Karl-Ulrich , VON ROEDERN, Erich , SCHOENAFINGER, Karl , ENHSEN, Alfons
IPC分类号： C07C275/54 , C07D213/56 , C07D307/56 , C07D333/26 , A61K31/17 , A61K31/33
CPC分类号： C07D213/82 , C07C275/54 , C07C2601/04 , C07D209/12 , C07D295/033 , C07D307/68 , C07D307/85 , C07D333/38
摘要： The invention relates to compounds of formula (I) wherein the radicals have the cited meaning, in addition to the physiologically compatible salts thereof. The compounds, for example, can be used as medicaments for preventing and treating type 2 diabetes.
摘要翻译： 本发明涉及式（I）的化合物worin的基团具有所引用的含义，除了其生理学上相容的盐。 的化合物，例如，可以用作药物用于预防和治疗2型糖尿病。
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公开(公告)号：EP0975569A1
公开(公告)日：2000-02-02
申请号：EP97919377.8
申请日：1997-04-17
申请人： Novartis AG
IPC分类号： C07C37/60 , C07C39/30 , C07C65/21 , C07C275/54
CPC分类号： C07C37/60 , C07C41/06 , C07C201/08 , C07C39/30 , C07C205/37 , C07C43/225
摘要： Preparation of 2,5-dichlorophenol by selectively oxidizing 1,4-dichlorobenzene using a peroxo-, hydroperoxo-, superoxo- or alkylperoxo-metal species in the presence of formic or an alkanoic acid.
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8.发明授权
公开(公告)号：EP0375069B1
公开(公告)日：1994-03-09
申请号：EP89203251.7
申请日：1989-12-18
IPC分类号： C07C275/62 , C07C275/28 , C07C275/54 , A01N47/34
CPC分类号： C07C335/28 , A01N47/34 , C07C273/1854 , C07C275/62
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公开(公告)号：EP0461266A4
公开(公告)日：1993-09-01
申请号：EP91900951
申请日：1990-12-25
发明人： SUZUKI, YASUYUKI KORIYAMA KASEI CO., LTD. , WATANABE, YUJI KORIYAMA KASEI CO., LTD. , FUJITA, TOSHINAO KORIYAMA KASEI CO., LTD. , DEN, NARUO KORIYAMA KASEI CO., LTD.
IPC分类号： A01N47/34 , C07C275/54 , C07F7/22
CPC分类号： A01N47/34 , C07C275/54 , C07F7/2216 , C07F7/2296
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公开(公告)号：EP0318782B1
公开(公告)日：1993-01-20
申请号：EP88119293.4
申请日：1988-11-21
申请人： BAYER AG
IPC分类号： C07C275/54 , C07C335/26 , C07C331/28 , C07C265/12 , A01N47/34
CPC分类号： C07C335/26 , A01N47/34 , C07C265/12 , C07C275/54 , C07C331/28
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