公开(公告)号：EP2822558A2

公开(公告)日：2015-01-14

申请号：EP13757357.2

申请日：2013-03-06

申请人： The Board Of Trustees Of The UniversityOf Illinois ,  Vanquish Oncology, Inc.

发明人： HERGENROTHER, Paul J. ,  BOTHAM, Rachel C. ,  FAN, Timothy M. ,  GILBERT, Mark, J. ,  HANDLEY, Michael K. ,  ROTH, Howard S. ,  TARASOW, Theodore M.

IPC分类号： A61K31/495 ,  A61K31/7048 ,  A61K31/4965 ,  A61K31/282 ,  A61K31/138 ,  A61K31/337 ,  A61K31/704 ,  A61K31/404 ,  A61K33/24 ,  A61K47/40 ,  A61P35/00

摘要： The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds.

公开(公告)号：EP2822558B1

公开(公告)日：2020-02-19

申请号：EP13757357.2

申请日：2013-03-06

申请人： The Board of Trustees of the University of Illinois ,  Vanquish Oncology, Inc.

发明人： HERGENROTHER, Paul J. ,  BOTHAM, Rachel C. ,  FAN, Timothy M. ,  GILBERT, Mark J. ,  HANDLEY, Michael K. ,  ROTH, Howard S. ,  TARASOW, Theodore M.

IPC分类号： A61K31/495 ,  A61K31/7048 ,  A61K31/4965 ,  A61K31/282 ,  A61K31/138 ,  A61K31/337 ,  A61K31/704 ,  A61K31/404 ,  A61K33/24 ,  A61K47/40 ,  A61P35/00 ,  A61K45/06 ,  A61K9/20 ,  A61K9/48 ,  A61K47/10 ,  A61K9/08 ,  A61K31/496 ,  A61K31/553 ,  A61K38/05