-
公开(公告)号：EP2822558A2
公开(公告)日：2015-01-14
申请号：EP13757357.2
申请日：2013-03-06
发明人： HERGENROTHER, Paul J. , BOTHAM, Rachel C. , FAN, Timothy M. , GILBERT, Mark, J. , HANDLEY, Michael K. , ROTH, Howard S. , TARASOW, Theodore M.
IPC分类号： A61K31/495 , A61K31/7048 , A61K31/4965 , A61K31/282 , A61K31/138 , A61K31/337 , A61K31/704 , A61K31/404 , A61K33/24 , A61K47/40 , A61P35/00
摘要： The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds.
-
公开(公告)号：EP2819661A2
公开(公告)日：2015-01-07
申请号：EP13755595.9
申请日：2013-03-04
申请人： Hergenrother, Paul J. , Botham, Rachel C. , Fan, Timothy M. , Gilbert, Mark J. , Handley, Michael K. , Tarasow, Theodore M. , The Board Of Trustees Of The UniversityOf Illinois , Vanquish Oncology, Inc.
发明人： HERGENROTHER, Paul J. , BOTHAM, Rachel C. , GILBERT, Mark J. , HANDLEY, Michael K. , TARASOW, Theodore M.
IPC分类号： A61K31/05 , A61K31/085 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/37 , A61K31/4184 , A61K31/4965 , A61K47/40 , A61P35/00 , A61P35/02
CPC分类号： A61K31/495 , A61K9/0019 , A61K9/008 , A61K9/2054 , A61K9/4858 , A61K31/437 , A61K47/40 , A61K2300/00
摘要： The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods the use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds.
-
公开(公告)号：EP2768308A1
公开(公告)日：2014-08-27
申请号：EP12840771.5
申请日：2012-10-12
申请人： The Board Of Trustees Of The UniversityOf Illinois , The Board of Regents of The University of Texas System
IPC分类号： A01N43/42
CPC分类号： A61K31/4745 , A61K31/47 , A61K45/06 , C07D471/04 , C07F9/6561 , C07H15/26
摘要： Compounds of Formula (I) can be selectively lethal toward a variety of different cancer cell types. The compounds are useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in chemotherapeutic therapy.
-
公开(公告)号：EP2819661B1
公开(公告)日：2016-11-09
申请号：EP13755595.9
申请日：2013-03-04
发明人： HERGENROTHER, Paul J. , BOTHAM, Rachel C. , FAN, Timothy M. , GILBERT, Mark J. , HANDLEY, Michael K. , TARASOW, Theodore M.
IPC分类号： A61K31/05 , A61K31/085 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/37 , A61K31/4184 , A61K31/4965 , A61K47/40 , A61P35/00 , A61P35/02 , A61K31/437 , A61K31/495 , A61K9/00 , A61K9/20 , A61K9/48
CPC分类号： A61K31/495 , A61K9/0019 , A61K9/008 , A61K9/2054 , A61K9/4858 , A61K31/437 , A61K47/40 , A61K2300/00
-
公开(公告)号：EP2822558B1
公开(公告)日：2020-02-19
申请号：EP13757357.2
申请日：2013-03-06
发明人： HERGENROTHER, Paul J. , BOTHAM, Rachel C. , FAN, Timothy M. , GILBERT, Mark J. , HANDLEY, Michael K. , ROTH, Howard S. , TARASOW, Theodore M.
IPC分类号： A61K31/495 , A61K31/7048 , A61K31/4965 , A61K31/282 , A61K31/138 , A61K31/337 , A61K31/704 , A61K31/404 , A61K33/24 , A61K47/40 , A61P35/00 , A61K45/06 , A61K9/20 , A61K9/48 , A61K47/10 , A61K9/08 , A61K31/496 , A61K31/553 , A61K38/05
-
公开(公告)号：EP3290035A1
公开(公告)日：2018-03-07
申请号：EP17180400.8
申请日：2013-03-06
申请人： The Board of Trustees of the University of Illinois , Vanquish Oncology, Inc. , The Johns Hopkins University
发明人： HERGENROTHER, Paul J. , BOTHAM, Rachel C. , FAN, Timothy M. , GILBERT, Mark J. , HANDLEY, Michael K. , JOSHI, Avadhut , RIGGINS, Gregory J. , TARASOW, Theodore M.
IPC分类号： A61K31/495 , A61K31/4188 , A61P35/00 , A61K9/00 , A61K9/20 , A61K9/48 , A61K47/10
CPC分类号： A61K31/495 , A61K9/0019 , A61K9/008 , A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K31/4188 , A61K31/53 , A61K47/10 , A61K2300/00
摘要： The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds.
-
公开(公告)号：EP3290035B1
公开(公告)日：2019-05-15
申请号：EP17180400.8
申请日：2013-03-06
申请人： The Board of Trustees of the University of Illinois , Vanquish Oncology, Inc. , The Johns Hopkins University
-
公开(公告)号：EP2822546B1
公开(公告)日：2017-07-12
申请号：EP13758061.9
申请日：2013-03-06
申请人： The Board of Trustees of the University of Illinois , Vanquish Oncology, Inc. , The Johns Hopkins University
发明人： HERGENROTHER, Paul J. , BOTHAM, Rachel C. , FAN, Timothy M. , GILBERT, Mark J. , HANDLEY, Michael K. , JOSHI, Avadhut , RIGGINS, Gregory J. , TARASOW, Theodore M.
IPC分类号： A61K31/495 , A61K31/4188 , A61P35/00 , A61K9/00 , A61K9/20 , A61K9/48 , A61K47/10
CPC分类号： A61K31/495 , A61K9/0019 , A61K9/008 , A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K31/4188 , A61K47/10 , A61K2300/00
-
9.发明公开PROCASPASE COMBINATION THERAPY FOR GLIOBLASTOMA 有权PROCASPASE KOMBINATIONSTHERAPIE ZUR BEHANDLUNG VON KREBS
公开(公告)号：EP2822546A1
公开(公告)日：2015-01-14
申请号：EP13758061.9
申请日：2013-03-06
申请人： The Board of Trustees of the University of Illinois , Vanquish Oncology, Inc. , The Johns Hopkins University
发明人： HERGENROTHER, Paul J. , BOTHAM, Rachel C. , FAN, Timothy M. , GILBERT, Mark J. , HANDLEY, Michael K. , JOSHI, Avadhut , RIGGINS, Gregory J. , TARASOW, Theodore M.
IPC分类号： A61K31/05 , A61K31/175 , A61K31/4172 , A61K31/4192 , A61K31/495 , A61P35/00
CPC分类号： A61K31/495 , A61K9/0019 , A61K9/008 , A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K31/4188 , A61K47/10 , A61K2300/00
摘要： The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds.
摘要翻译： 本发明提供了诱导细胞死亡的组合物和方法，例如癌细胞死亡。 公开了化合物和相关使用方法的组合，包括在治疗中使用化合物治疗癌症和选择性诱导细胞凋亡。 所公开的药物组合可以具有比其它化合物和化合物组合更低的神经毒性作用。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.016 秒)
