专利检索 ap:("The Board of Regents of The University of Texas System") AND inv:"MEYER, Adam, J." 第 1 页

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发明公开
T7 RNA POLYMERASE VARIANTS WITH EXPANDED SUBSTRATE RANGE AND ENHANCED TRANSCRIPTIONAL YIELD 审中-公开
标题翻译： T7-RNA-POLYMERASEVARIANTEN MIT ERWEITERTEM SUBSTRATBEREICH UNDERHÖHTEMTRANSKRIPTIONSERTRAG

公开(公告)号：EP3119873A1

公开(公告)日：2017-01-25

申请号：EP15765692.7

申请日：2015-03-20

申请人： The Board of Regents of The University of Texas System

发明人： ELLINGTON, Andrew, D. , MEYER, Adam, J.

IPC分类号： C12N1/19 , C12N15/11 , C12N9/22

CPC分类号： C12N9/1247 , C12N15/111 , C12N15/115 , C12N2310/141 , C12N2310/16 , C12N2320/51 , C12N2330/00 , C12N2330/51 , C12P19/34 , C12Y207/07006

摘要： Disclosed are T7 RNA polymerase variants with enhanced transcriptional activity. T7 RNA polymerase variants are known which have the ability to incorporate modified ribonucleotides into growing RNA molecules. However, these variants have relatively low levels of transcriptional activity. Presented herein are mutations that increase the transcriptional activity of the variants with broad substrate range.

摘要翻译： 公开了具有增强的转录活性的T7RNA聚合酶变体。 T7 RNA聚合酶变体是已知的，其具有将修饰的核糖核苷酸掺入生长中的RNA分子的能力。然而，这些变体具有相对低水平的转录活性。本文提出的是增加具有宽底物范围的变体的转录活性的突变。