公开(公告)号：EP3256438A1

公开(公告)日：2017-12-20

申请号：EP16749694.2

申请日：2016-02-09

申请人： The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College ,  University of Southern California

发明人： BAZAN, Nicolas, G. ,  PETASIS, Nicos, A.

IPC分类号： C07C51/09

CPC分类号： C07C57/03 ,  C07C59/42 ,  C07C69/587 ,  C07C69/732 ,  C07F9/10 ,  C07F9/106

摘要： This disclosure provides compounds, pharmaceutical compositions, and methods of use for the prevention and treatment of inflammatory diseases or degenerative diseases including neurodegenerative diseases. Embodiments of the present disclosure provide compounds related to very long chain polyunsaturated fatty acids, pharmaceutical compositions containing the provided compounds, and methods of treating a subject with a condition or disease using provided compounds or pharmaceutical compositions.

公开(公告)号：EP2209471A2

公开(公告)日：2010-07-28

申请号：EP08845477.2

申请日：2008-10-30

申请人： The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： BAZAN, Nicolas, G. ,  HE, Jiu-Cheng ,  BAZAN, Haydee, E. P.

IPC分类号： A61K31/232 ,  A61P27/02

CPC分类号： A61K31/232 ,  A01N1/02 ,  A01N1/0226 ,  A61K45/06 ,  A61K2300/00

摘要： Lipoxin A4 and its analogs have been discovered to promote the cell proliferation of cornea endothelial cells, and thus promote the proper functioning of the labile tissue layer of cornea endothelial cells. These lipoxin compounds can be administered alone or in combination with other known compounds as a solution that can be topically administered to decrease the swelling of the cornea or maintain the clarity of the cornea. Lipoxin A4 or its analogs can also be combined with other known nutritive compounds to form a solution for storage of a cornea prior to transplantation.

摘要翻译： 脂氧素A4及其类似物已被发现可促进角膜内皮细胞的细胞增殖，从而促进角膜内皮细胞的不稳定组织层的正常功能。 这些脂氧素化合物可以单独或与其他已知化合物组合施用，作为可以局部施用以减少角膜肿胀或保持角膜透明度的溶液。 脂氧素A4或其类似物也可以与其他已知的营养化合物组合以形成用于在移植之前储存角膜的溶液。