专利检索 ap:("The Board of Trustees of The Leland S. Stanford Junior University") AND inv:"McEACHERN, Ernest, John" 第 1 页

1.

发明公开
THE ADDITION OF OXYGEN NUCLEOPHILES TO VINYL EPOXIDES 审中-公开
标题翻译： SAUERSTOFFNUKLEOPHILEN与乙烯基环氧化物加成

公开(公告)号：EP1112240A1

公开(公告)日：2001-07-04

申请号：EP99944698.2

申请日：1999-09-08

申请人： The Board of Trustees of The Leland S. Stanford Junior University

发明人： TROST, Barry, Martin , McEACHERN, Ernest, John , TOSTE, Francisco, Dean

IPC分类号： C07B53/00

CPC分类号： C07D317/12 , C07B53/00 , C07C41/03 , C07D307/28 , C07D309/24 , C07D313/04 , C07D317/38 , C07C43/178 , C07C43/23 , C07C43/1787

摘要： Nucleophilic oxygen species, such as primary alcohols, carboxylates, and water, are added to vinyl epoxides in a highly regioselective and enantioselective manner, providing a convenient route to enantiomerically enriched 2,2-diols and oxygen-containing heterocycles. The reaction employs a chireal Pd(0) complex and a borane or borate as co-catalysts. Also described are similar additions of nitrogen nucleophils, and the addition of carbonates to vinyl epoxides using a chiral Pd(0) catalyst.