公开(公告)号：EP3908577A1

公开(公告)日：2021-11-17

申请号：EP20738100.5

申请日：2020-01-09

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： PHAM, Edward ,  GLENN, Jeffrey S. ,  SMITH, Mark

IPC分类号： C07D277/40 ,  C07D277/42 ,  C07D277/46

公开(公告)号：EP3983017A1

公开(公告)日：2022-04-20

申请号：EP20822601.9

申请日：2020-06-09

申请人： The Board Of Trustees Of The Leland Stanford Junior University

发明人： GLENN, Jeffrey S. ,  PHAM, Edward ,  XIONG, Anming

IPC分类号： A61K45/06 ,  A61P1/16 ,  A61P31/12 ,  A61P31/14 ,  A61K38/21 ,  A61P43/00

公开(公告)号：EP3800257A1

公开(公告)日：2021-04-07

申请号：EP20208373.9

申请日：2017-03-01

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： GLENN, Jeffrey S. ,  HAGEY, Rachel ,  PHAM, Edward

IPC分类号： C12N15/113 ,  A61K31/712 ,  A61K31/7125 ,  A61P31/16

摘要： Methods of inhibiting influenza A virus in a sample are provided. Aspects of the methods include contacting a sample comprising viral RNA (vRNA) having a PSL2 motif with an effective amount of an agent that specifically binds the PSL2 motif to inhibit the influenza A virus. Also provided are methods of treating or preventing influenza A virus infection in a subject. Also provided are methods for screening a candidate agent for the ability to inhibit influenza A virus in a cell, the method comprising: contacting a sample with a candidate agent; and determining whether the candidate agent specifically binds to the PSL2 motif of vRNA. Also provided are compounds and pharmaceutical compositions comprising an oligonucleotide sequence complementary to a PB2 vRNA region that find use in the subject methods.

公开(公告)号：EP4389221A2

公开(公告)日：2024-06-26

申请号：EP24159464.7

申请日：2017-03-01

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： GLENN, Jeffrey S. ,  HAGEY, Rachel ,  PHAM, Edward

IPC分类号： A61P31/16

CPC分类号： A61K45/06 ,  A61K31/7084 ,  A61K31/7088 ,  C12N2310/1120130101 ,  C12N2310/31520130101 ,  C12N2310/323120130101 ,  A61P31/16 ,  C12N15/1131 ,  A61K31/7125

摘要： Methods of inhibiting influenza A virus in a sample are provided. Aspects of the methods include contacting a sample comprising viral RNA (vRNA) having a PSL2 motif with an effective amount of an agent that specifically binds the PSL2 motif to inhibit the influenza A virus. Also provided are methods of treating or preventing influenza A virus infection in a subject. Also provided are methods for screening a candidate agent for the ability to inhibit influenza A virus in a cell, the method comprising: contacting a sample with a candidate agent; and determining whether the candidate agent specifically binds to the PSL2 motif of vRNA. Also provided are compounds and pharmaceutical compositions comprising an oligonucleotide sequence complementary to a PB2 vRNA region that find use in the subject methods.

公开(公告)号：EP3423107A1

公开(公告)日：2019-01-09

申请号：EP17760733.0

申请日：2017-03-01

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： GLENN, Jeffrey S. ,  HAGEY, Rachel ,  PHAM, Edward

IPC分类号： A61K48/00 ,  A61K31/7056 ,  A61K31/545 ,  A61K31/5377 ,  A61K31/43 ,  A61K31/165