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公开(公告)号：EP4103713A1
公开(公告)日：2022-12-21
申请号：EP21780993.8
申请日：2021-02-12
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公开(公告)号：EP2763532A1
公开(公告)日：2014-08-13
申请号：EP12838386.6
申请日：2012-10-05
申请人： The Board of Trustees of the Leland Stanford Junior University , The Regents of The University of California
IPC分类号： A01N43/00
CPC分类号： C07D417/12 , C07D277/40 , C07D277/42 , C07D277/44 , C07D277/46
摘要： Compounds and methods are provided for the treatment of pathogen infections. In some embodiments, the anti-infective compounds have broad spectrum activity against a variety of infective diseases, where the diseases are caused by pathogens containing a basic amino acid PIP-2 pincer (BAAPP) domain that interacts with phosphatidylinositol 4,5-bisphosphate (PIP-2) to mediate pathogen replication. Also provided are methods of inhibiting a PI4-kinase and methods of inhibiting viral infection. In some embodiments, the compound is a PI4-kinase inhibiting compound that is a 5-aryl-thiazole. The subject compounds may be formulated or provided to a subject in combination with a second anti-infective agent, e.g. interferon, ribivarin, and the like.
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公开(公告)号：EP3983017A1
公开(公告)日：2022-04-20
申请号：EP20822601.9
申请日：2020-06-09
发明人： GLENN, Jeffrey S. , PHAM, Edward , XIONG, Anming
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公开(公告)号：EP3800257A1
公开(公告)日：2021-04-07
申请号：EP20208373.9
申请日：2017-03-01
发明人： GLENN, Jeffrey S. , HAGEY, Rachel , PHAM, Edward
IPC分类号： C12N15/113 , A61K31/712 , A61K31/7125 , A61P31/16
摘要： Methods of inhibiting influenza A virus in a sample are provided. Aspects of the methods include contacting a sample comprising viral RNA (vRNA) having a PSL2 motif with an effective amount of an agent that specifically binds the PSL2 motif to inhibit the influenza A virus. Also provided are methods of treating or preventing influenza A virus infection in a subject. Also provided are methods for screening a candidate agent for the ability to inhibit influenza A virus in a cell, the method comprising: contacting a sample with a candidate agent; and determining whether the candidate agent specifically binds to the PSL2 motif of vRNA. Also provided are compounds and pharmaceutical compositions comprising an oligonucleotide sequence complementary to a PB2 vRNA region that find use in the subject methods.
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公开(公告)号：EP2763532B1
公开(公告)日：2018-09-19
申请号：EP12838386.6
申请日：2012-10-05
申请人： The Board of Trustees of the Leland Stanford Junior University , The Regents of the University of California
IPC分类号： C07D277/44 , C07D417/12 , C07D277/40 , C07D277/46 , C07D277/42
CPC分类号： C07D417/12 , C07D277/40 , C07D277/42 , C07D277/44 , C07D277/46
摘要： Compounds and methods are provided for the treatment of pathogen infections. In some embodiments, the anti-infective compounds have broad spectrum activity against a variety of infective diseases, where the diseases are caused by pathogens containing a basic amino acid PIP-2 pincer (BAAPP) domain that interacts with phosphatidylinositol 4,5-bisphosphate (PIP-2) to mediate pathogen replication. Also provided are methods of inhibiting a PI4-kinase and methods of inhibiting viral infection. In some embodiments, the compound is a PI4-kinase inhibiting compound that is a 5-aryl-thiazole. The subject compounds may be formulated or provided to a subject in combination with a second anti-infective agent, e.g. interferon, ribivarin, and the like.
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公开(公告)号：EP4389221A2
公开(公告)日：2024-06-26
申请号：EP24159464.7
申请日：2017-03-01
发明人： GLENN, Jeffrey S. , HAGEY, Rachel , PHAM, Edward
IPC分类号： A61P31/16
CPC分类号： A61K45/06 , A61K31/7084 , A61K31/7088 , C12N2310/1120130101 , C12N2310/31520130101 , C12N2310/323120130101 , A61P31/16 , C12N15/1131 , A61K31/7125
摘要： Methods of inhibiting influenza A virus in a sample are provided. Aspects of the methods include contacting a sample comprising viral RNA (vRNA) having a PSL2 motif with an effective amount of an agent that specifically binds the PSL2 motif to inhibit the influenza A virus. Also provided are methods of treating or preventing influenza A virus infection in a subject. Also provided are methods for screening a candidate agent for the ability to inhibit influenza A virus in a cell, the method comprising: contacting a sample with a candidate agent; and determining whether the candidate agent specifically binds to the PSL2 motif of vRNA. Also provided are compounds and pharmaceutical compositions comprising an oligonucleotide sequence complementary to a PB2 vRNA region that find use in the subject methods.
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公开(公告)号：EP3941909A1
公开(公告)日：2022-01-26
申请号：EP20774679.3
申请日：2020-03-19
申请人： The Board Of Trustees Of The Leland Stanford Junior University , Glenn, Jeffrey S. , Smith, Mark , Pham, Edward A. , Basu, Kaustabh , Stabler, Stephen
IPC分类号： C07D277/42 , A61K31/426 , A61K45/06 , A61P35/00
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公开(公告)号：EP3423107A1
公开(公告)日：2019-01-09
申请号：EP17760733.0
申请日：2017-03-01
发明人： GLENN, Jeffrey S. , HAGEY, Rachel , PHAM, Edward
IPC分类号： A61K48/00 , A61K31/7056 , A61K31/545 , A61K31/5377 , A61K31/43 , A61K31/165
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公开(公告)号：EP3908577A1
公开(公告)日：2021-11-17
申请号：EP20738100.5
申请日：2020-01-09
发明人： PHAM, Edward , GLENN, Jeffrey S. , SMITH, Mark
IPC分类号： C07D277/40 , C07D277/42 , C07D277/46
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公开(公告)号：EP3419980A1
公开(公告)日：2019-01-02
申请号：EP17757378.9
申请日：2017-02-24
申请人： The Board of Trustees of the Leland Stanford Junior University , The Regents of the University of California
发明人： GLENN, Jeffrey S. , GELMAN, Michael A. , TAVSHANJIAN, Brandon , SHOKAT, Kevan , CHOONG, Ingrid , SMITH, Mark
IPC分类号： C07D498/04 , C07D419/04
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