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    PERSONAL GLUCOSE METERS FOR DETECTION AND QUANTIFICATION OF A BROAD RANGE OF ANALYTES
    2.
    发明公开
    PERSONAL GLUCOSE METERS FOR DETECTION AND QUANTIFICATION OF A BROAD RANGE OF ANALYTES 有权
    于检测个性化的血糖仪和分析物建立了广泛的定量

    公开(公告)号：EP2576806A1

    公开(公告)日：2013-04-10

    申请号：EP11787400.8

    申请日：2011-05-26

    申请人： The Board of Trustees of the University of Illinois

    发明人： LU, Yi ,  XIANG, Yu

    IPC分类号： C12Q1/00

    CPC分类号： G01N33/558 ,  C12Q1/34 ,  C12Q1/54

    摘要： A general methodology for the development of highly sensitive and selective sensors that can achieve portable, low-cost and quantitative detection of a broad range of targets using only a personal glucose meter (PGM) is disclosed. The method uses recognition molecules that are specific for a target agent, enzymes that can convert an enzyme substrate into glucose, and PGM. Also provided are sensors, which can include a solid support to which is attached a recognition molecule that permits detection of a target agent, wherein the recognition molecule specifically binds to the target agent in the presence of the target agent but not significantly to other agents as well as an enzyme that can catalyze the conversion of a substance into glucose, wherein the enzyme is attached directly or indirectly to the recognition molecule, and wherein in the presence of the target agent the enzyme can convert the substance into glucose. The disclosed sensors can be part of a lateral flow device. Methods of using such sensors for detecting target agents are also provided.