公开(公告)号：EP2231176A2

公开(公告)日：2010-09-29

申请号：EP08860890.6

申请日：2008-12-15

申请人： The Brigham and Women's Hospital, Inc. ,  Immune Disease Institute Inc. ,  The General Hospital Corporation

发明人： ELLEDGE, Stephen ,  LIEBERMAN, Judy ,  BRASS, Abraham L.

IPC分类号： A61K38/08 ,  A61P31/18

CPC分类号： C12N15/111 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/12 ,  C12N2330/51

摘要： Disclosed herein are methods for treating and/or preventing HIV infection in a cell. The methods involve downmodulating one or more of the HIV-dependency factors (HDFs) disclosed herein to thereby treat and/or prevent HIV infection in the cell. Downmodulating the HDFs can be by contacting the cell with an agent that downmodulates the HDF. Also disclosed herein are methods for treating and/or preventing HIV infection in a subject comprising downmodulating one or more of the HIV-dependency factors (HDFs), disclosed herein, to thereby treat and/or prevent HIV infection in the subject. The method may further comprise selecting a subject diagnosed with or at risk for HIV infection, prior to downmodulating. Downmodulating the HDFs may comprise administering an agent that downmodulates the HDF to the subject such that the agent contacts HIV host cells of the subject. The agent may inhibit HDF gene expression, protein synthesis, HDF function or HDF activity, or combinations thereof.

公开(公告)号：EP1789447B1

公开(公告)日：2012-04-25

申请号：EP05807329.7

申请日：2005-08-15

申请人： Immune Disease Institute, Inc.

发明人： LIEBERMAN, Judy ,  SONG, Erwei

IPC分类号： C12N15/113 ,  C07K14/46 ,  C07K16/00 ,  C07K16/08

CPC分类号： C12N15/1138 ,  C07K14/46 ,  C07K16/1063 ,  C07K2317/77 ,  C07K2319/74 ,  C07K2319/85 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1132 ,  C12N15/1135 ,  C12N15/1136 ,  C12N2310/14 ,  C12N2310/3513 ,  C12N2320/32

摘要： The invention provides a method of RNA interference, which comprises contacting the cell with a fusion protein-double stranded RNA complex, the complex comprising the double stranded RNA segment containing a double stranded RNA of interest and a fusion protein, the fusion protein comprising (1) a targeting moiety, which will specifically binds to a site on a target cell, and (2) a binding moiety, which will bind to the double stranded RNA, wherein the double stranded RNA segment initiates RNA interference in the cell.